The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation*
Calderwood D, Zent R, Grant R, Rees D, Hynes R, Ginsberg M. The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation*. Journal Of Biological Chemistry 1999, 274: 28071-28074. PMID: 10497155, DOI: 10.1074/jbc.274.40.28071.Peer-Reviewed Original ResearchConceptsTalin head domainIntegrin cytoplasmic tailsCytoplasmic tailIntegrin-binding siteHead domainActin cytoskeletonFragment of talinIntegrin beta tailsIntegrin adhesion receptorsSingle point mutationFocal adhesionsCytoplasmic domainCytoplasmic proteinsBeta tailsIntegrin functionIntegrin localizationTalinIntegrin activationIntegrin affinityActin filamentsAdhesion receptorsIntegrin-cytoskeletal interactionsPoint mutationsCytoskeletonStructural mimics