2017
Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens
Parchure A, Vyas N, Mayor S. Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens. Trends In Cell Biology 2017, 28: 157-170. PMID: 29132729, PMCID: PMC6941938, DOI: 10.1016/j.tcb.2017.10.003.Peer-Reviewed Original Research
2015
Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion
Parchure A, Vyas N, Ferguson C, Parton R, Mayor S. Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion. Molecular Biology Of The Cell 2015, 26: 4700-4717. PMID: 26490120, PMCID: PMC4678025, DOI: 10.1091/mbc.e15-09-0671.Peer-Reviewed Original ResearchConceptsLong-range signalingMultivesicular bodiesEndocytic deliveryDrosophila wing imaginal discWing imaginal discsESCRT proteinsLipidated proteinsSecreted morphogenImaginal discsNanoscale organizationExovesiclesHedgehogSignalingProteinOligomerizationHhDependent processesESCRTSelective effectTurn actMorphogensEndocytosisAqueous milieuSecretionComplexes