2024
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Watkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.Peer-Reviewed Original ResearchConceptsBacterial pathobiontsRespiratory virusesBurden of virusesSARS-CoV-2Innate immune activationSARS-CoV-2 viral loadDynamic host-pathogen interactionsInnate immune responseViral coinfectionCytokine profileViral loadNasal virusImmune activationProinflammatory responseIL-1BNasopharyngeal samplesHost-pathogen interactionsImmune responseInterferon responsePathobiontsInnate immunityPaired samplesCXCL10Healthy 1-year-oldVirus
2019
Blood Utilization and Transfusion Reactions in Pediatric Patients Transfused with Conventional or Pathogen Reduced Platelets
Schulz WL, McPadden J, Gehrie EA, Bahar B, Gokhale A, Ross R, Price N, Spencer BR, Snyder E. Blood Utilization and Transfusion Reactions in Pediatric Patients Transfused with Conventional or Pathogen Reduced Platelets. The Journal Of Pediatrics 2019, 209: 220-225. PMID: 30885645, DOI: 10.1016/j.jpeds.2019.01.046.Peer-Reviewed Original ResearchConceptsRed cell utilizationTransfusion reactionsNICU patientsInfants 0Platelet dosesNeonatal intensive care unit patientsPathogen-reduced platelet transfusionsIntensive care unit patientsTertiary care hospitalCare unit patientsShort-term safetyChildren ages 1Similar utilization patternsQuality assurance reviewPED patientsTransfusion trendsSubsequent transfusionsUnit patientsCare hospitalPediatric patientsPediatric populationPlatelet transfusionsBlood utilizationAdditional dosesPLT transfusions