Longitudinal analyses reveal immunological misfiring in severe COVID-19
Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, Ellingson MK, Mao T, Oh JE, Israelow B, Takahashi T, Tokuyama M, Lu P, Venkataraman A, Park A, Mohanty S, Wang H, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Muenker MC, Fournier JB, Campbell M, Odio CD, Casanovas-Massana A, Herbst R, Shaw A, Medzhitov R, Schulz W, Grubaugh N, Dela Cruz C, Farhadian S, Ko A, Omer S, Iwasaki A. Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature 2020, 584: 463-469. PMID: 32717743, PMCID: PMC7477538, DOI: 10.1038/s41586-020-2588-y.Peer-Reviewed Original ResearchConceptsSevere COVID-19Moderate COVID-19Immune signaturesDisease outcomeCOVID-19Disease trajectoriesInterleukin-5Early immune signaturesInnate cell lineagesType 2 effectorsT cell numbersPoor clinical outcomeWorse disease outcomesImmune response profileCoronavirus disease 2019Distinct disease trajectoriesCytokine levelsImmunological correlatesImmune profileClinical outcomesEarly elevationImmune profilingIL-13Immunoglobulin EDisease 2019Development and Validation of the Quick COVID-19 Severity Index: A Prognostic Tool for Early Clinical Decompensation
Haimovich AD, Ravindra NG, Stoytchev S, Young HP, Wilson FP, van Dijk D, Schulz WL, Taylor RA. Development and Validation of the Quick COVID-19 Severity Index: A Prognostic Tool for Early Clinical Decompensation. Annals Of Emergency Medicine 2020, 76: 442-453. PMID: 33012378, PMCID: PMC7373004, DOI: 10.1016/j.annemergmed.2020.07.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBetacoronavirusClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingEmergency Service, HospitalFemaleHumansMaleMiddle AgedOxygen Inhalation TherapyPandemicsPneumonia, ViralRespiratory InsufficiencyRetrospective StudiesRisk AssessmentSARS-CoV-2Severity of Illness IndexYoung AdultConceptsCOVID-19 Severity IndexQuick COVID-19 severity indexQuick Sequential Organ Failure AssessmentSequential Organ Failure AssessmentOrgan Failure AssessmentHours of admissionRespiratory failureSeverity IndexScoring systemSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Bedside scoring systemOxygen requirementPneumonia severity scoresHours of hospitalizationElixhauser Comorbidity IndexEmergency department patientsSeverity Index scoreCOVID-19 patientsSyndrome coronavirus 2Coronavirus disease 2019Failure AssessmentSimple scoring systemIndependent test cohortImpact of COVID-19 Pandemic on Laboratory Utilization
Durant TJS, Peaper DR, Ferguson D, Schulz WL. Impact of COVID-19 Pandemic on Laboratory Utilization. The Journal Of Applied Laboratory Medicine 2020, 5: 1194-1205. PMID: 32663258, PMCID: PMC7454564, DOI: 10.1093/jalm/jfaa121.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusClinical Laboratory ServicesClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingFacilities and Services UtilizationHumansIncidencePandemicsPneumonia, ViralPolymerase Chain ReactionReagent Kits, DiagnosticRetrospective StudiesSARS-CoV-2Specimen HandlingAgile Health Care Analytics: Enabling Real-Time Disease Surveillance With a Computational Health Platform
Schulz WL, Durant T, Torre CJ, Hsiao AL, Krumholz HM. Agile Health Care Analytics: Enabling Real-Time Disease Surveillance With a Computational Health Platform. Journal Of Medical Internet Research 2020, 22: e18707. PMID: 32442130, PMCID: PMC7257473, DOI: 10.2196/18707.Peer-Reviewed Original ResearchConceptsReal-time dataHealth information technologyReal-world dataHealth platformInformation technologyCombination of technologiesReal timeSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Timely informationRespiratory syndrome coronavirus 2PlatformRespiratory tract infectionsSyndrome coronavirus 2Health care systemTract infectionsCoronavirus disease (COVID-19) outbreakIncident casesCoronavirus 2Novel applicationTechnologyAnalyticsHealth systemCare systemSpecific pathogens