Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
Wu X, Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S, Chen S, Jaenisch R, Zhang F, Sharp PA. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nature Biotechnology 2014, 32: 670-676. PMID: 24752079, PMCID: PMC4145672, DOI: 10.1038/nbt.2889.Peer-Reviewed Original ResearchConceptsMammalian cellsGenome-wide bindingGenome-wide analysisWidespread bindingBindingCellsCRISPRLow levelsCleavage