2023
Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System
Zhang L, Park J, Dong M, Arsala D, Xia S, Chen J, Sosa D, Atlas J, Long M, Chen S. Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System. Genome Biology And Evolution 2023, 15: evad081. PMID: 37170918, PMCID: PMC10210621, DOI: 10.1093/gbe/evad081.Peer-Reviewed Original ResearchT cell adaptive immunityNew genesPositive selectionRapid gene duplicationEvolution of longevityStrong positive selectionVertebrate immune systemAdaptive immunityAmino acid substitutionsVertebrate lineageGene ageGene duplicationEutherian radiationGene annotationGenome assemblyRapid originationVertebrate speciesPlacental mammalsHuman genesImmunity genesMolecular adaptationsNucleotide sequenceGenetic constructionNegative regulatorInteraction pathway
2011
Highly Tissue Specific Expression of Sphinx Supports Its Male Courtship Related Role in Drosophila melanogaster
Chen Y, Dai H, Chen S, Zhang L, Long M. Highly Tissue Specific Expression of Sphinx Supports Its Male Courtship Related Role in Drosophila melanogaster. PLOS ONE 2011, 6: e18853. PMID: 21541324, PMCID: PMC3082539, DOI: 10.1371/journal.pone.0018853.Peer-Reviewed Original ResearchMeSH KeywordsAnimal StructuresAnimalsBase PairingBase SequenceBrainConserved SequenceCourtshipDrosophila melanogasterFemaleGene Expression ProfilingGene Expression RegulationGenome, InsectGreen Fluorescent ProteinsMaleMolecular Sequence DataMutationOrgan SpecificityPeripheral Nervous SystemPromoter Regions, GeneticRNA, UntranslatedSexual Behavior, AnimalTransformation, GeneticConceptsDrosophila melanogasterBp regionCourtship behaviorNon-coding RNA genesWhole genome expression profilingBp upstream regionTissue-specific expressionGenome expression profilingMale courtship behaviorMale accessory glandsMelanogaster subgroupDrosophila speciesD. virilisRNA genesGene categoriesProtein functionKnockout mutationsWing hairsMale courtshipTarget genesExpression profilingGFP signalNegative regulatorEnhancer elementsExpression signals