2014
A spatial simulation approach to account for protein structure when identifying non-random somatic mutations
Ryslik GA, Cheng Y, Cheung KH, Bjornson RD, Zelterman D, Modis Y, Zhao H. A spatial simulation approach to account for protein structure when identifying non-random somatic mutations. BMC Bioinformatics 2014, 15: 231. PMID: 24990767, PMCID: PMC4227039, DOI: 10.1186/1471-2105-15-231.Peer-Reviewed Original Research
2010
Analysis of membrane proteins in metagenomics: Networks of correlated environmental features and protein families
Patel PV, Gianoulis TA, Bjornson RD, Yip KY, Engelman DM, Gerstein MB. Analysis of membrane proteins in metagenomics: Networks of correlated environmental features and protein families. Genome Research 2010, 20: 960-971. PMID: 20430783, PMCID: PMC2892097, DOI: 10.1101/gr.102814.109.Peer-Reviewed Original ResearchConceptsProtein familyMembrane proteinsMembrane protein familyRecent metagenomic studiesMembrane protein contentAdditional environmental featuresProtein diversityDisparate habitatsGenomic diversityPhosphate transporterProtein variationMetagenomic sequencesMetagenomic studiesEnvironmental featuresIron transporterHuman impactProteinOceanographic variablesMarine sitesEcological analysisTransportersDiversityProtein contentFamilyClimate change
2009
RigidFinder: A fast and sensitive method to detect rigid blocks in large macromolecular complexes
Abyzov A, Bjornson R, Felipe M, Gerstein M. RigidFinder: A fast and sensitive method to detect rigid blocks in large macromolecular complexes. Proteins Structure Function And Bioinformatics 2009, 78: 309-324. PMID: 19705487, DOI: 10.1002/prot.22544.Peer-Reviewed Original ResearchConceptsLarge macromolecular complexesMacromolecular complexesLarge-scale conformational changesRNA polymerase IIT7 RNA polymeraseMultiple polypeptide chainsPolymerase IIRNA polymeraseDistance conservationPhosphate dikinaseDifferent conformationsInter-residue distancesLarge complexesConformational changesPolypeptide chainDomain motionPartial refoldingFurther distinguishing featureConformationStructure determinationComplexesDikinaseSensitive identificationGroELIdentification