2022
Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing
Ramirez V, Litvinov B, Gunawardane NA, Zhao CW, Yotter C, Quraishi IH, Blumenfeld H. Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing. Epileptic Disorders 2022, 24: 899-905. PMID: 35904040, PMCID: PMC10042123, DOI: 10.1684/epd.2022.1472.Peer-Reviewed Original ResearchConceptsFocal seizuresResponsiveness testingCurrent International LeagueClinical practice settingEEG-video monitoringEpilepsy monitoring unitImportant clinical settingsEpilepsy guidelinesPatient groupFocal epilepsyIctal eventsClinical careInternational LeagueSeizuresPatientsClinical settingPractice settingsClassification guidelinesFurther studiesEpilepsyResponsivenessRecall of experiencesPreliminary findingsRecall testingSetting
2020
Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels
Quraishi IH, Mercier MR, McClure H, Couture RL, Schwartz ML, Lukowski R, Ruth P, Kaczmarek LK. Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels. Scientific Reports 2020, 10: 3213. PMID: 32081855, PMCID: PMC7035262, DOI: 10.1038/s41598-020-60028-z.Peer-Reviewed Original ResearchConceptsMaximum electroshock-induced seizuresEpilepsy of infancyPentylenetetrazole-induced seizuresVideo-EEG monitoringElectroshock-induced seizuresForms of epilepsyWild-type miceSlack channelsImpaired motor skillsProcedural motor learningMotor skillsWild-type animalsSevere intellectual disabilityOpen-field behaviorCortical seizuresKCNT1 geneSpontaneous seizuresFocal seizuresSeizure susceptibilitySeizure activityType miceMouse modelAnimal modelsInterictal spikesSeizures