2023
Early breast cancer risk detection: a novel framework leveraging polygenic risk scores and machine learning
Tao L, Ye Y, Zhao H. Early breast cancer risk detection: a novel framework leveraging polygenic risk scores and machine learning. Journal Of Medical Genetics 2023, 60: 960-964. PMID: 37055164, DOI: 10.1136/jmg-2022-108582.Peer-Reviewed Original ResearchConceptsBreast cancerPolygenic risk scoresRisk scoreBC risk assessmentClinical breast examNon-genetic risk factorsHigh-risk individualsFemale participantsBreast examCancer deathCommon cancerBC screeningRisk factorsBC diagnosisDisease risk predictionDiagnostic stepsPopulation screeningGenetic riskRisk predictionUK BiobankCancerDiagnosisDiagnostic pipelineWomenDetection test
2022
Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer
Li L, Zhang Y, Ren Y, Cheng Z, Zhang Y, Wang X, Zhao H, Lu H. Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer. Frontiers In Bioengineering And Biotechnology 2022, 10: 849798. PMID: 35646860, PMCID: PMC9136039, DOI: 10.3389/fbioe.2022.849798.Peer-Reviewed Original ResearchUpper gastrointestinal cancerCancer stem cellsPoor eating habitsTumor stem cellsChronic inflammationGastrointestinal cancerEating habitsStem cellsGastrointestinal cancer stem cellsPersistent chronic inflammationGastrointestinal cancer diagnosisCore signal pathwaysWnt pathway genesMucosa damagePoor outcomeAggressive carcinomasInflammatory genesSpecific cancer stem cellsCancer diagnosisCancerSignal pathwayInflammationWnt pathwayCell typesCells
2020
A comprehensive genetic and epidemiological association analysis of vitamin D with common diseases/traits in the UK Biobank
Ye Y, Yang H, Wang Y, Zhao H. A comprehensive genetic and epidemiological association analysis of vitamin D with common diseases/traits in the UK Biobank. Genetic Epidemiology 2020, 45: 24-35. PMID: 32918767, DOI: 10.1002/gepi.22357.Peer-Reviewed Original ResearchConceptsVitamin DPotential causal roleCausal roleAutoimmune/inflammatory diseasesMR analysisMendelian randomization analysisMultiple sclerosisFemur fracturesLeg fracturesInflammatory diseasesOvarian cancerEpidemiological associationMusculoskeletal diseasesMetabolic diseasesNeurological diseasesD concentrationsEpidemiological analysisDiseaseRandomization analysisUK BiobankSuch associationsCancerAssociationHealthDiseases/traits