2022
A Zero-Inflated Logistic Normal Multinomial Model for Extracting Microbial Compositions
Zeng Y, Pang D, Zhao H, Wang T. A Zero-Inflated Logistic Normal Multinomial Model for Extracting Microbial Compositions. Journal Of The American Statistical Association 2022, 118: 2356-2369. DOI: 10.1080/01621459.2022.2044827.Peer-Reviewed Original ResearchMaximum likelihood estimationEfficient iterative algorithmProbabilistic PCA modelsEmpirical Bayes approachApproximation estimatorVariational approximationExcessive zerosM-estimationAsymptotic normalityIterative algorithmLikelihood estimationBayes approachCount dataHigh dimensionalityRaw count dataMultinomial modelExtensive simulationsZerosSupplementary materialMicrobiome dataCompositional natureEstimationPCA modelComposition estimationApproximation
2010
Asymptotic efficiency and finite-sample properties of the generalized profiling estimation of parameters in ordinary differential equations
Qi X, Zhao H. Asymptotic efficiency and finite-sample properties of the generalized profiling estimation of parameters in ordinary differential equations. The Annals Of Statistics 2010, 38: 435-481. DOI: 10.1214/09-aos724.Peer-Reviewed Original ResearchOrdinary differential equationsDifferential equationsBasis functionsEstimation procedureAsymptotic covariance matrixEfficient estimation procedureFinite sample propertiesMaximum likelihood estimationODE solutionStatistical propertiesAsymptotic normalityAsymptotic efficiencySpline approximationTrue solutionCovariance matrixComputational efficiencyLikelihood estimationLinear combinationUniform normApproximationEstimation methodEquationsObserved dataDynamic behaviorSolution