2021
Association of Angiotensin‐Converting Enzyme Inhibitors and Angiotensin Receptor Blockers with the Risk of Hospitalization and Death in Hypertensive Patients with Coronavirus Disease‐19
Khera R, Clark C, Lu Y, Guo Y, Ren S, Truax B, Spatz ES, Murugiah K, Lin Z, Omer SB, Vojta D, Krumholz HM. Association of Angiotensin‐Converting Enzyme Inhibitors and Angiotensin Receptor Blockers with the Risk of Hospitalization and Death in Hypertensive Patients with Coronavirus Disease‐19. Journal Of The American Heart Association 2021, 10: e018086. PMID: 33624516, PMCID: PMC8403305, DOI: 10.1161/jaha.120.018086.Peer-Reviewed Original ResearchConceptsAngiotensin receptor blockersLower hospitalization riskACE inhibitorsCOVID-19 hospitalizationHospitalization riskHospital mortalityReceptor blockersValidation cohortAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionEnzyme inhibitorsSyndrome coronavirus 2 infectionAngiotensin converting enzyme (ACE) inhibitorsCoronavirus 2 infectionRisk of hospitalizationCoronavirus disease-19SARS-CoV-2COVID-19 preventionHypertensive patientsInpatient cohortOutpatient cohortContemporary cohortStudy cohortOutpatient studyMedicare group
2016
China PEACE risk estimation tool for in-hospital death from acute myocardial infarction: an early risk classification tree for decisions about fibrinolytic therapy
Li X, Li J, Masoudi FA, Spertus JA, Lin Z, Krumholz HM, Jiang L. China PEACE risk estimation tool for in-hospital death from acute myocardial infarction: an early risk classification tree for decisions about fibrinolytic therapy. BMJ Open 2016, 6: e013355. PMID: 27798032, PMCID: PMC5093680, DOI: 10.1136/bmjopen-2016-013355.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionAcute myocardial infarctionFibrinolytic therapyLow-risk groupMyocardial infarctionHospital deathHospital mortalitySegment elevation myocardial infarctionCardiac Events (PEACE) studyHospital death riskComposite of deathElevation myocardial infarctionSystolic blood pressureTime of presentationRelative risk reductionCross-sectional studyBaseline mortality riskAcute reperfusionMajor bleedingReperfusion therapyBlood pressureDerivation cohortStudy cohortChina PatientValidation cohort
2012
A Validated Prediction Tool for Initial Survivors of In-Hospital Cardiac Arrest
Chan PS, Spertus JA, Krumholz HM, Berg RA, Li Y, Sasson C, Nallamothu BK, Investigators F. A Validated Prediction Tool for Initial Survivors of In-Hospital Cardiac Arrest. JAMA Internal Medicine 2012, 172: 947-953. PMID: 22641228, PMCID: PMC3517176, DOI: 10.1001/archinternmed.2012.2050.Peer-Reviewed Original ResearchConceptsFavorable neurological survivalHospital cardiac arrestNeurological survivalCardiac arrestNeurological statusDerivation cohortValidation cohortInitial cardiac arrest rhythmIn-Hospital Cardiac ArrestBaseline neurological statusFavorable neurological statusGuidelines-Resuscitation registryCardiac arrest rhythmSevere neurological deficitsPulseless ventricular tachycardiaMultivariate logistic regressionSimple prediction toolRenal insufficiencyArrest rhythmNeurological deficitsHepatic insufficiencyMechanical ventilationMalignant diseaseVentricular tachycardiaInitial survivors
2011
An Administrative Claims Model for Profiling Hospital 30-Day Mortality Rates for Pneumonia Patients
Bratzler DW, Normand SL, Wang Y, O'Donnell WJ, Metersky M, Han LF, Rapp MT, Krumholz HM. An Administrative Claims Model for Profiling Hospital 30-Day Mortality Rates for Pneumonia Patients. PLOS ONE 2011, 6: e17401. PMID: 21532758, PMCID: PMC3075250, DOI: 10.1371/journal.pone.0017401.Peer-Reviewed Original ResearchConceptsMortality rateDerivation cohortValidation cohortModel derivation cohortAge 66 yearsPrincipal discharge diagnosisAdministrative diagnosis codesStandardized mortality rateRisk-adjustment variablesQuality of careState mortality ratesAdministrative Claims ModelClaims-based modelsIndex hospitalizationPatient demographicsDischarge diagnosisOutpatient encountersPneumonia mortalityPneumonia patientsRetrospective studyDiagnosis codesPneumonia casesMortality estimatesOutcome measuresProfiling Hospitals
2000
Predictors of readmission among elderly survivors of admission with heart failure
Krumholz H, Chen Y, Wang Y, Vaccarino V, Radford M, Horwitz R. Predictors of readmission among elderly survivors of admission with heart failure. American Heart Journal 2000, 139: 72-77. PMID: 10618565, DOI: 10.1016/s0002-8703(00)90311-9.Peer-Reviewed Original ResearchConceptsHigh-risk patientsHeart failureRisk predictorsCause readmissionClinical factorsValidation cohortHeart failure-related readmissionsPrior heart failurePatients 65 yearsPredictors of readmissionRisk of readmissionMedical record reviewGroup of patientsPrincipal discharge diagnosisResource-intensive interventionsMedicare administrative databasesCreatinine levelsElderly patientsPrior admissionReadmission ratesDerivation cohortRecord reviewDischarge diagnosisAdministrative databasesConnecticut hospitals
1999
Comparing AMI Mortality Among Hospitals in Patients 65 Years of Age and Older
Krumholz H, Chen J, Wang Y, Radford M, Chen Y, Marciniak T. Comparing AMI Mortality Among Hospitals in Patients 65 Years of Age and Older. Circulation 1999, 99: 2986-2992. PMID: 10368115, DOI: 10.1161/01.cir.99.23.2986.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionWhite blood cell countPatients 65 yearsSystolic blood pressureCongestive heart failureMedical chart reviewReceiver-operating characteristic curveBlood cell countRisk-adjusted outcomesYears of ageAdministrative billing codesRisk-adjustment modelsHospital outcomesSerum creatinineChart reviewDerivation cohortHeart failurePatient characteristicsBlood pressureCardiac arrestValidation cohortCandidate predictor variablesAMI mortalityBilling codes