2018
Accurate estimation of cardiovascular risk in a non-diabetic adult: detecting and correcting the error in the reported Framingham Risk Score for the Systolic Blood Pressure Intervention Trial population
Warner F, Dhruva SS, Ross JS, Dey P, Murugiah K, Krumholz HM. Accurate estimation of cardiovascular risk in a non-diabetic adult: detecting and correcting the error in the reported Framingham Risk Score for the Systolic Blood Pressure Intervention Trial population. BMJ Open 2018, 8: e021685. PMID: 30037874, PMCID: PMC6059296, DOI: 10.1136/bmjopen-2018-021685.Peer-Reviewed Original ResearchConceptsSystolic Blood Pressure Intervention TrialFramingham risk scoreCardiovascular riskRisk scoreStudy populationStudy participantsNon-diabetic adultsTotal study populationHigh-risk populationClinical trial dataClinical trial sitesTrial populationIntervention trialsRisk populationsNew England JournalIndependent investigatorsTrial dataSecondary analysisSPRINT trialSPRINT dataTrialsRiskScoresParticipantsPopulation
2005
Performance of the Thrombolysis in Myocardial Infarction (TIMI) ST-elevation myocardial infarction risk score in a national cohort of elderly patients
Rathore SS, Weinfurt KP, Foody JM, Krumholz HM. Performance of the Thrombolysis in Myocardial Infarction (TIMI) ST-elevation myocardial infarction risk score in a national cohort of elderly patients. American Heart Journal 2005, 150: 402-410. PMID: 16169316, PMCID: PMC2790534, DOI: 10.1016/j.ahj.2005.03.069.Peer-Reviewed Original ResearchConceptsThirty-day mortality rateTIMI scoreElderly patientsMortality rateRisk scoreMyocardial Infarction (TIMI) risk scoreHigh TIMI scoreMyocardial Infarction (TIMI) scoreCommunity-based cohortReperfusion therapyTrial cohortPrognostic discriminationTrial populationNational cohortModest discriminationPatientsUS hospitalsSTEMICohortScore discriminationScoresThrombolysis
2003
Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure
Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF, Ordin DL, Krumholz HM. Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. American Heart Journal 2003, 146: 250-257. PMID: 12891192, DOI: 10.1016/s0002-8703(03)00189-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAge FactorsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsCross-Sectional StudiesFemaleHeart FailureHospitalizationHumansMaleMineralocorticoid Receptor AntagonistsPatient SelectionRandomized Controlled Trials as TopicSpironolactoneUnited StatesVentricular Dysfunction, LeftConceptsLeft ventricular systolic functionVentricular systolic functionHeart failureEnrollment criteriaClinical trialsOlder personsSystolic functionRandomized Aldactone Evaluation Study (RALES) trialHospitalized older personsRandomized Intervention TrialTrials of agentsLeft ventricular dysfunctionCongestive heart failureHeart failure patientsAcute care hospitalsCross-sectional studySubgroups of ageCommunity-based practiceTrial eligibilityVentricular dysfunctionFailure patientsOlder patientsCare hospitalMERIT-HFTrial population