2023
Distinguishing features of long COVID identified through immune profiling
Klein J, Wood J, Jaycox J, Dhodapkar R, Lu P, Gehlhausen J, Tabachnikova A, Greene K, Tabacof L, Malik A, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott I, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng T, Xu L, Geraghty A, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick J, Kaminski N, Omer S, Krumholz H, Guan L, Dela Cruz C, van Dijk D, Ring A, Putrino D, Iwasaki A. Distinguishing features of long COVID identified through immune profiling. Nature 2023, 623: 139-148. PMID: 37748514, PMCID: PMC10620090, DOI: 10.1038/s41586-023-06651-y.Peer-Reviewed Original ResearchConceptsLong COVIDSARS-CoV-2Infection syndromeExaggerated humoral responseSoluble immune mediatorsEpstein-Barr virusPost-exertional malaiseCross-sectional studyHigher antibody responseImmune mediatorsImmune phenotypingImmune profilingHumoral responseAntibody responseLymphocyte populationsCOVID statusUnbiased machineCortisol levelsLC statusRelevant biomarkersViral pathogensSyndromeCOVIDFuture studiesBiological features
2021
Ticagrelor vs Clopidogrel for Patients With Acute Coronary Syndrome Undergoing Percutaneous Intervention—Reply
You SC, Gupta A, Krumholz HM. Ticagrelor vs Clopidogrel for Patients With Acute Coronary Syndrome Undergoing Percutaneous Intervention—Reply. JAMA 2021, 325: 890-891. PMID: 33651089, DOI: 10.1001/jama.2020.26023.Peer-Reviewed Original Research
2020
Antiplatelet strategies in acute coronary syndromes: design and methodology of an international collaborative network meta-analysis of randomized controlled trials
Madhavan MV, Bikdeli B, Redfors B, Biondi-Zoccai G, Varunok NJ, Burton JR, Crowley A, Francese DP, Gupta A, Der Nigoghossian C, Chatterjee S, Palmerini T, Benedetto U, You S, Ohman M, Kastrati A, Steg PG, Gibson C, Angiolillo DJ, Krumholz HM, Stone GW. Antiplatelet strategies in acute coronary syndromes: design and methodology of an international collaborative network meta-analysis of randomized controlled trials. Minerva Cardioangiologica 2020 DOI: 10.23736/s0026-4725.20.05353-0.Peer-Reviewed Original Research
2018
Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload?
Goldwater DS, Dharmarajan K, McEwan BS, Krumholz HM. Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? Journal Of Hospital Medicine 2018, 13 PMID: 29813141, DOI: 10.12788/jhm.2986.Peer-Reviewed Original ResearchConceptsPosthospital syndromeAllostatic overloadAutonomic nervous systemMultiple organ systemsHospital dischargeInflammatory markersAdverse eventsHospital readmissionAdrenal axisAdverse outcomesPlausible etiologyPathophysiologic consequencesElevated riskNervous systemNarrative reviewOrgan systemsEnhanced vulnerabilityElevated levelsHospital environmentTraditional hospital environmentSyndromeMaladaptive statesOverloadOutcomesPossible mechanism
2016
Reply What Is the Prevalence of Diabetes Mellitus in Patients With Principal and Secondary Takotsubo Syndrome?
Murugiah K, Desai NN, Krumholz HM. Reply What Is the Prevalence of Diabetes Mellitus in Patients With Principal and Secondary Takotsubo Syndrome? JACC Heart Failure 2016, 4: 417-418. PMID: 27126286, DOI: 10.1016/j.jchf.2016.02.003.Commentaries, Editorials and Letters
2013
2013 ACCF/AHA Key Data Elements and Definitions for Measuring the Clinical Management and Outcomes of Patients With Acute Coronary Syndromes and Coronary Artery Disease
Cannon CP, Brindis RG, Chaitman BR, Cohen DJ, Cross JT, Drozda JP, Fesmire FM, Fintel DJ, Fonarow GC, Fox KA, Gray DT, Harrington RA, Hicks KA, Hollander JE, Krumholz H, Labarthe DR, Long JB, Mascette AM, Meyer C, Peterson ED, Radford MJ, Roe MT, Richmann JB, Selker HP, Shahian DM, Shaw RE, Sprenger S, Swor R, Underberg JA, Van de Werf F, Weiner BH, Weintraub WS. 2013 ACCF/AHA Key Data Elements and Definitions for Measuring the Clinical Management and Outcomes of Patients With Acute Coronary Syndromes and Coronary Artery Disease. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2013, 12: 65-105. PMID: 23680811, DOI: 10.1097/hpc.0b013e3182846e16.Peer-Reviewed Original Research2013 ACCF/AHA Key Data Elements and Definitions for Measuring the Clinical Management and Outcomes of Patients With Acute Coronary Syndromes and Coronary Artery Disease A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Acute Coronary Syndromes and Coronary Artery Disease Clinical Data Standards)
Cannon CP, Brindis RG, Chaitman BR, Cohen DJ, Cross JT, Drozda JP, Fesmire FM, Fintel DJ, Fonarow GC, Fox KA, Gray DT, Harrington RA, Hicks KA, Hollander JE, Krumholz H, Labarthe DR, Long JB, Mascette AM, Meyer C, Peterson ED, Radford MJ, Roe MT, Richmann JB, Selker HP, Shahian DM, Shaw RE, Sprenger S, Swor R, Underberg JA, Van de Werf F, Weiner BH, Weintraub WS. 2013 ACCF/AHA Key Data Elements and Definitions for Measuring the Clinical Management and Outcomes of Patients With Acute Coronary Syndromes and Coronary Artery Disease A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Acute Coronary Syndromes and Coronary Artery Disease Clinical Data Standards). Journal Of The American College Of Cardiology 2013, 61: 992-1025. PMID: 23369353, PMCID: PMC5681220, DOI: 10.1016/j.jacc.2012.10.005.Peer-Reviewed Original Research2013 ACCF/AHA Key Data Elements and Definitions for Measuring the Clinical Management and Outcomes of Patients With Acute Coronary Syndromes and Coronary Artery Disease
Cannon CP, Brindis RG, Chaitman BR, Cohen DJ, Cross JT, Drozda JP, Fesmire FM, Fintel DJ, Fonarow GC, Fox KA, Gray DT, Harrington RA, Hicks KA, Hollander JE, Krumholz H, Labarthe DR, Long JB, Mascette AM, Meyer C, Peterson ED, Radford MJ, Roe MT, Richmann JB, Selker HP, Shahian DM, Shaw RE, Sprenger S, Swor R, Underberg JA, Van de Werf F, Weiner BH, Weintraub WS. 2013 ACCF/AHA Key Data Elements and Definitions for Measuring the Clinical Management and Outcomes of Patients With Acute Coronary Syndromes and Coronary Artery Disease. Circulation 2013, 127: 1052-1089. PMID: 23357718, DOI: 10.1161/cir.0b013e3182831a11.Peer-Reviewed Original ResearchPost-Hospital Syndrome — An Acquired, Transient Condition of Generalized Risk
Krumholz HM. Post-Hospital Syndrome — An Acquired, Transient Condition of Generalized Risk. New England Journal Of Medicine 2013, 368: 100-102. PMID: 23301730, PMCID: PMC3688067, DOI: 10.1056/nejmp1212324.Peer-Reviewed Original Research
2010
Implementation of a Registry for Acute Coronary Syndrome in Resource-Limited Settings: Barriers and Opportunities
Safavi K, Linnander EL, Allam AA, Bradley EH, Krumholz HM. Implementation of a Registry for Acute Coronary Syndrome in Resource-Limited Settings: Barriers and Opportunities. Asia Pacific Journal Of Public Health 2010, 22: 90s-95s. PMID: 20566539, DOI: 10.1177/1010539510373017.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeCardiovascular diseaseCoronary syndromeHealth systemClinical Outcomes RegistryEvidence-based careCause of deathResource limited settingsResource-limited settingsWorld health systemsQuality improvement activitiesMiddle-income countriesOutcomes RegistryHigh-quality treatmentBlame-free cultureClinical registryRegistrySyndromeImprovement activitiesHospitalDiseaseSetting
2005
Relation of Anemia at Discharge to Survival After Acute Coronary Syndromes
Vaglio J, Safley DM, Rahman M, Kosiborod M, Jones P, Thompson R, Krumholz HM, Spertus JA. Relation of Anemia at Discharge to Survival After Acute Coronary Syndromes. The American Journal Of Cardiology 2005, 96: 496-499. PMID: 16098299, DOI: 10.1016/j.amjcard.2005.04.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnemiaAngina, UnstableBiomarkersCause of DeathCoronary AngiographyDisease ProgressionElectrocardiographyFemaleFollow-Up StudiesHematocritHumansMaleMiddle AgedMissouriMyocardial InfarctionPatient DischargePrognosisProspective StudiesSeverity of Illness IndexSurvival RateTime FactorsTroponin
2001
American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes
Cannon C, Battler A, Brindis R, Cox J, Ellis S, Every N, Flaherty J, Harrington R, Krumholz H, Simoons M, Van De Werf F, Weintraub W, Mitchell K, Morrisson S, Brindis R, Anderson H, Cannom D, Chitwood W, Cigarroa J, Collins-Nakai R, Ellis S, Gibbons R, Grover F, Heidenreich P, Khandheria B, Knoebel S, Krumholz H, Malenka D, Mark D, Mckay C, Passamani E, Radford M, Riner R, Schwartz J, Shaw R, Shemin R, Van Fossen D, Verrier E, Watkins M, Phoubandith D, Furnelli T. American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes. Journal Of The American College Of Cardiology 2001, 38: 2114-2130. PMID: 11738323, DOI: 10.1016/s0735-1097(01)01702-8.Peer-Reviewed Original Research
1999
Cost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes
Krumholz H. Cost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes. Contemporary Cardiology 1999, 601-610. DOI: 10.1007/978-1-59259-731-4_25.Peer-Reviewed Original ResearchAcute coronary syndromeCoronary heart diseaseHealth care resourcesCost-effectiveness analysisHealth care systemHealth care expendituresCoronary syndromeCardiac eventsPharmacologic interventionsHeart diseaseEfficacious therapyCardiovascular diseaseCare resourcesNew interventionsCare expendituresCare systemHealth benefitsInterventionCare organizationsDiseaseTreatmentStandard practicePatientsHospitalSyndrome