2020
Sulodexide versus Control and the Risk of Thrombotic and Hemorrhagic Events: Meta-Analysis of Randomized Trials
Bikdeli B, Chatterjee S, Kirtane AJ, Parikh SA, Andreozzi GM, Desai NR, Francese DP, Gibson CM, Piazza G, Goldhaber SZ, Eikelboom JW, Krumholz HM, Stone GW. Sulodexide versus Control and the Risk of Thrombotic and Hemorrhagic Events: Meta-Analysis of Randomized Trials. Seminars In Thrombosis And Hemostasis 2020, 46: 908-918. PMID: 33086402, DOI: 10.1055/s-0040-1716874.Peer-Reviewed Original ResearchConceptsDeep vein thrombosisUse of sulodexideCause mortalityCardiovascular mortalityReduced oddsPulmonary embolismOdds ratioOdds of VTESafety of sulodexideCardiovascular risk factorsCochrane Central RegisterPeripheral arterial diseaseHistory of MIThrombotic cardiovascular diseasesRandom-effects modelCardiovascular efficacyOral glycosaminoglycansCardiovascular outcomesHemorrhagic eventsCentral RegisterVein thrombosisControlled TrialsArterial diseaseRandomized trialsRisk factors
2018
Implications of coronary artery calcium testing on risk stratification for lipid-lowering therapy according to the 2016 European Society of Cardiology recommendations: The MESA study
Bittencourt MS, Blankstein R, Blaha MJ, Sandfort V, Agatston AS, Budoff MJ, Blumenthal RS, Krumholz HM, Nasir K. Implications of coronary artery calcium testing on risk stratification for lipid-lowering therapy according to the 2016 European Society of Cardiology recommendations: The MESA study. European Journal Of Preventive Cardiology 2018, 25: 1887-1898. PMID: 30043629, DOI: 10.1177/2047487318788930.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersClinical Decision-MakingCoronary AngiographyCoronary Artery DiseaseDyslipidemiasFemaleHumansHypolipidemic AgentsIncidenceLipidsMaleMiddle AgedPractice Guidelines as TopicPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsUnited StatesVascular CalcificationConceptsLipid-lowering treatmentCoronary artery calciumLipid-lowering therapyArtery calciumHigher cardiovascular mortalityCardiovascular mortalityUncontrolled groupCoronary Artery Calcium TestingCoronary heart disease eventsEuropean SocietyHeart disease eventsCardiovascular mortality ratesCardiovascular risk assessmentLow-risk groupCardiology recommendationsCardiology guidelinesCardiovascular riskESC recommendationsRisk stratificationMESA participantsCalcium testingRisk groupsGroup 31Lower incidenceMESA study
2008
Long-term Prognosis of Acute Kidney Injury After Acute Myocardial Infarction
Parikh CR, Coca SG, Wang Y, Masoudi FA, Krumholz HM. Long-term Prognosis of Acute Kidney Injury After Acute Myocardial Infarction. JAMA Internal Medicine 2008, 168: 987-995. PMID: 18474763, DOI: 10.1001/archinte.168.9.987.Peer-Reviewed Original ResearchConceptsSevere acute kidney injuryAcute kidney injuryAcute myocardial infarctionMild acute kidney injuryModerate acute kidney injuryKidney injuryLong-term riskMyocardial infarctionSeverity of AKIAdjusted hazard ratioLong-term mortalitySerum creatinine levelsLong-term prognosisCooperative Cardiovascular ProjectElderly Medicare patientsHigh-risk groupAssociation of severityHospital mortalityHospital survivorsCause mortalityCardiovascular mortalityCreatinine levelsHazard ratioInpatient mortalityCommon complication
2007
Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments
Kosiborod M, Soto GE, Jones PG, Krumholz HM, Weintraub WS, Deedwania P, Spertus JA. Identifying Heart Failure Patients at High Risk for Near-Term Cardiovascular Events With Serial Health Status Assessments. Circulation 2007, 115: 1975-1981. PMID: 17420346, DOI: 10.1161/circulationaha.106.670901.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireHeart failure outpatientsHealth status assessmentCause mortalityCardiovascular mortalityKaplan-Meier survival analysisHigh-risk patientsHeart failure patientsAcute myocardial infarctionProportional hazards modelIntensity of treatmentStatus assessmentKCCQ scoresCardiovascular deathCardiovascular eventsClinical deteriorationMultivariable adjustmentFailure patientsHeart failureOutpatient visitsMyocardial infarctionHigh riskHospitalizationPatientsCombined outcome
2006
Underrepresentation of Renal Disease in Randomized Controlled Trials of Cardiovascular Disease
Coca SG, Krumholz HM, Garg AX, Parikh CR. Underrepresentation of Renal Disease in Randomized Controlled Trials of Cardiovascular Disease. JAMA 2006, 296: 1377-1384. PMID: 16985230, DOI: 10.1001/jama.296.11.1377.Peer-Reviewed Original ResearchConceptsChronic congestive heart failureCongestive heart failureRenal diseaseRenal functionHeart failureSubgroup analysisCardiovascular diseaseCardiology/American Heart Association guidelinesAmerican Heart Association guidelinesAldosterone system antagonistsBaseline renal functionHeart Association guidelinesCardiovascular disease trialsCurrent American CollegeRandomized Controlled TrialsAcute myocardial infarctionEffects of interventionsRepresentation of patientsOriginal articlesBaseline characteristicsCardiovascular mortalityPatient characteristicsControlled TrialsPrognostic featuresMyocardial infarctionPrediction of medical morbidity and mortality after acute myocardial infarction in patients at increased psychosocial risk in the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) study
Jaffe AS, Krumholz HM, Catellier DJ, Freedland KE, Bittner V, Blumenthal JA, Calvin JE, Norman J, Sequeira R, O'Connor C, Rich MW, Sheps D, Wu C, Investigators F. Prediction of medical morbidity and mortality after acute myocardial infarction in patients at increased psychosocial risk in the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) study. American Heart Journal 2006, 152: 126-135. PMID: 16824842, DOI: 10.1016/j.ahj.2005.10.004.Peer-Reviewed Original ResearchConceptsPost-MI patientsAcute myocardial infarctionMyocardial infarctionLow social supportCardiovascular mortalityEnd pointNonfatal myocardial infarctionPrimary end pointSecondary end pointsLong-term mortalityPrior myocardial infarctionSignificant multivariable predictorsProportional hazards modelSocial supportKillip classCause mortalityElevated creatinineRecurrent infarctionAdverse eventsBaseline characteristicsBypass surgeryEjection fractionHeart failureMedical morbidityMedical predictors
2004
Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction
Soto GE, Jones P, Weintraub WS, Krumholz HM, Spertus JA. Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction. Circulation 2004, 110: 546-551. PMID: 15262843, DOI: 10.1161/01.cir.0000136991.85540.a9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmericasCardiovascular DiseasesCohort StudiesComorbidityDisease-Free SurvivalEplerenoneEuropeFemaleHealth Status IndicatorsHeart FailureHospitalizationHumansMaleMiddle AgedMineralocorticoid Receptor AntagonistsMyocardial InfarctionPrognosisProspective StudiesRisk FactorsSeverity of Illness IndexSpironolactoneConceptsKansas City Cardiomyopathy QuestionnaireAcute myocardial infarctionHeart failureKCCQ-OSMyocardial infarctionHealth statusKCCQ scoresCardiovascular mortalityPrognostic valueDisease-specific health status instrumentRecent acute myocardial infarctionSubsequent cardiovascular eventsEvent-free survivalOutpatient clinical practiceFirst outpatient visitHealth status instrumentsPatients' health statusQuality of lifeCardiovascular eventsClinical characteristicsOutpatient visitsMultivariable modelInternational cohortFunctional limitationsClinical practice
2001
An Evidence-Based Assessment of Federal Guidelines for Overweight and Obesity as They Apply to Elderly Persons
Heiat A, Vaccarino V, Krumholz HM. An Evidence-Based Assessment of Federal Guidelines for Overweight and Obesity as They Apply to Elderly Persons. JAMA Internal Medicine 2001, 161: 1194-1203. PMID: 11343442, DOI: 10.1001/archinte.161.9.1194.Peer-Reviewed Original ResearchConceptsCardiovascular mortalityElderly personsCause mortalityMortality riskCoronary heart disease eventsIdeal weightUS clinical guidelinesHeart disease eventsSignificant prognostic factorsTreatment of overweightBaseline health statusExcess mortality riskRelative mortality riskBody mass indexMiddle-aged populationHigher BMI valuesAdditional pertinent articlesEnglish-language studiesSpecific age groupsPrognostic factorsMass indexSignificant positive associationHealthy weightPrognostic importanceClinical guidelines