2022
Randomized controlled trials of biomarker targets
Erlendsdottir M, Crawford F. Randomized controlled trials of biomarker targets. Clinical Trials 2022, 20: 47-58. PMID: 36373783, PMCID: PMC9974557, DOI: 10.1177/17407745221131820.Peer-Reviewed Original ResearchConceptsBlood pressure targetsManagement of hypertensionPressure targetsTreatment strategiesBiomarker targetsControlled TrialsRandomized trialsPatient populationLower blood pressure targetsIntensive blood pressure controlAcute respiratory distress syndromePhysicians attemptNew randomized trialsBlood pressure controlRespiratory distress syndromeLack of blindingTrial patient populationValidity of trialsAdaptive treatment strategiesAntihypertensive medicationsAvailable medicationsDistress syndromeTreat analysisTime-varying confoundingTreatment algorithm
2020
Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks
Dean NE, Gsell PS, Brookmeyer R, Crawford FW, Donnelly CA, Ellenberg SS, Fleming TR, Halloran ME, Horby P, Jaki T, Krause PR, Longini IM, Mulangu S, Muyembe-Tamfum JJ, Nason MC, Smith PG, Wang R, Henao-Restrepo AM, De Gruttola V. Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks. New England Journal Of Medicine 2020, 382: 1366-1369. PMID: 32242365, PMCID: PMC7490833, DOI: 10.1056/nejmsb1905390.Peer-Reviewed Original ResearchMeSH KeywordsClinical ProtocolsCooperative BehaviorDisease OutbreaksHumansPublishingRandomized Controlled Trials as TopicResearch Design
2019
Divergent estimates of HIV incidence among people who inject drugs in Ukraine
Morozova O, Booth RE, Dvoriak S, Dumchev K, Sazonova Y, Saliuk T, Crawford FW. Divergent estimates of HIV incidence among people who inject drugs in Ukraine. International Journal Of Drug Policy 2019, 73: 156-162. PMID: 31405731, PMCID: PMC6899203, DOI: 10.1016/j.drugpo.2019.07.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Sectional StudiesFemaleHIV InfectionsHumansIncidenceMaleNeedle SharingRandomized Controlled Trials as TopicResearch DesignSelection BiasSubstance Abuse, IntravenousSurveys and QuestionnairesUkraineYoung AdultConceptsHIV incidenceStudy subjectsBio-behavioral surveillance surveysRecent syringe sharingPopulation of PWIDLongitudinal cohort studyDrug of choiceLow-risk individualsCross-sectional surveyBaseline characteristicsCohort studyAverage monthly numberRisk stratificationSyringe sharingIntervention trialsSurveillance SurveyHigh incidenceRisk individualsRCTsPWIDStudy designIncidenceDrugsFuture surveillanceSignificant differences