2022
Randomization for the susceptibility effect of an infectious disease intervention
Eck DJ, Morozova O, Crawford FW. Randomization for the susceptibility effect of an infectious disease intervention. Journal Of Mathematical Biology 2022, 85: 37. PMID: 36127558, PMCID: PMC9809173, DOI: 10.1007/s00285-022-01801-8.Peer-Reviewed Original ResearchConceptsInfectious disease interventionsInfection outcomesInfection riskDisease interventionDirect effectRandomized trialsTreatment allocationInfectious disease transmissionStudy subjectsHarmful treatmentPathogen of interestInterventionOutcomesTreatmentRandomization designVaccineDisease transmissionSusceptibility effectsTrialsRiskRandomizationInfectionIndividuals
2021
Identification of causal intervention effects under contagion
Cai X, Loh WW, Crawford FW. Identification of causal intervention effects under contagion. Journal Of Causal Inference 2021, 9: 9-38. PMID: 34676152, PMCID: PMC8528235, DOI: 10.1515/jci-2019-0033.Peer-Reviewed Original ResearchIntervention effectsInfectious disease transmission dynamicsInfection outcomesDisease transmission dynamicsHIV vaccine trialsInfectious disease outcomesTransmission dynamicsEffects of interventionsVaccine effectsIntervention trialsVaccine trialsClinical evaluationDisease outcomeOutcome dataTrialsTreatment effectsOutcomesCausal estimandsEmpirical trialPartnership modelInfectionBinary outcome data
2020
Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks
Dean NE, Gsell PS, Brookmeyer R, Crawford FW, Donnelly CA, Ellenberg SS, Fleming TR, Halloran ME, Horby P, Jaki T, Krause PR, Longini IM, Mulangu S, Muyembe-Tamfum JJ, Nason MC, Smith PG, Wang R, Henao-Restrepo AM, De Gruttola V. Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks. New England Journal Of Medicine 2020, 382: 1366-1369. PMID: 32242365, PMCID: PMC7490833, DOI: 10.1056/nejmsb1905390.Peer-Reviewed Original Research