2012
Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo
Gil-Henn H, Patsialou A, Wang Y, Warren MS, Condeelis JS, Koleske AJ. Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo. Oncogene 2012, 32: 2622-2630. PMID: 22777352, PMCID: PMC3473103, DOI: 10.1038/onc.2012.284.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast NeoplasmsCell Line, TumorCell ProliferationErbB ReceptorsFemaleGene Knockdown TechniquesHumansLung NeoplasmsMAP Kinase Signaling SystemMiceMice, SCIDNeoplasm InvasivenessNeoplasm MetastasisNeoplasm TransplantationProto-Oncogene Proteins c-ablSrc-Family KinasesTransplantation, HeterologousConceptsTumor cell invasionBreast cancer cellsTyrosine kinaseCancer cellsCell invasionNon-receptor tyrosine kinaseRas-MAPK signalingRas-MAPK pathwayGene expression patternsSrc tyrosine kinaseInvasion-associated genesUncontrolled cell divisionProliferation-associated genesMetastatic cancer cellsCell divisionExpression patternsEGF receptorTumor cell proliferationPromotes InvasionMouse xenograft modelCell proliferationMultistep processGenetic aberrationsKinaseGenes
2007
Defective T Cell Development and Function in the Absence of Abelson Kinases
Gu JJ, Zhang N, He YW, Koleske AJ, Pendergast AM. Defective T Cell Development and Function in the Absence of Abelson Kinases. The Journal Of Immunology 2007, 179: 7334-7343. PMID: 18025176, DOI: 10.4049/jimmunol.179.11.7334.Peer-Reviewed Original ResearchConceptsT cell developmentT cellsMutant miceCell-autonomous roleT cell-dependent AgCD8 T cellsListeria monocytogenes infectionT cell expansionCell developmentNumber of thymocytesT cell functionDouble-positive stageDouble-negative populationDefective T cell developmentConditional knockout miceT cells resultsNull T cellsTCR-induced signalingCytokine productionMonocytogenes infectionAb productionKnockout miceThymocyte proliferationConditional deletionMice