Minghao Zhong, MD, PhD
Associate Professor Adjunct in PathologyCards
About
Research
Publications
2022
A novel key driver gene of Alzheimer’s disease impacts AD‐related cognitive deficit, pathology and neuro‐inflammation in sex‐ and APOE‐specific manners
Cai D, Guo L, Cao J, Zhang L, Huang M, Hou J, Zhu L, Julia T, Zhong M, Goate A, Zhang B. A novel key driver gene of Alzheimer’s disease impacts AD‐related cognitive deficit, pathology and neuro‐inflammation in sex‐ and APOE‐specific manners. Alzheimer's & Dementia 2022, 17 DOI: 10.1002/alz.054111.Peer-Reviewed Original ResearchMolecular mechanismsGene co-expression network analysisCo-expression network analysisPossible post-translational modificationsGene perturbation studiesDimorphic expression patternPost-translational modificationsSystems biology approachSpecific mannerRNA expression datasetsKey driver genesSex-biased differenceMulti-omics dataSex-specific contributionsMultiscale network analysisLDL receptor-related proteinUptake of apoEBiology approachGene candidatesRegulator geneExpression patternsNetwork analysisReceptor-related proteinDriver genesExpression datasets
2020
A novel interaction between AD risk genes synaptojanin 1 and reticulon‐3 potentially impacts synaptic function and endo‐lysosomal trafficking during disease development and progression
Cai D, Huang M, Cao J, Hou J, Zhu L, Zhang L, Pero A, Guo L, Julia T, Zhong M, Goate A, Zhang B, Yan R. A novel interaction between AD risk genes synaptojanin 1 and reticulon‐3 potentially impacts synaptic function and endo‐lysosomal trafficking during disease development and progression. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043247.Peer-Reviewed Original ResearchSynaptic functionAPOE genotypeEndo-lysosomal traffickingReticulon 3Strongest genetic risk factorWhole brain lysateNon-demented subjectsPostmortem brain samplesGenetic risk factorsAMP-AD consortiumDifferent brain regionsHuman postmortem brain samplesLOAD patientsRisk factorsAD pathogenesisMolecular signaling mechanismsSporadic ADDisease pathogenesisSynaptosomal fractionBrain samplesMouse brainApoE4Brain regionsCognitive functionSynaptojanin 1A Comparative Analysis of Immunohistochemical Profile of Primary and Metastatic Endometrial Endometrioid Carcinoma
Xu K, Ye Q, Han L, Zhong M. A Comparative Analysis of Immunohistochemical Profile of Primary and Metastatic Endometrial Endometrioid Carcinoma. American Journal Of Clinical Pathology 2020, 154: s32-s33. DOI: 10.1093/ajcp/aqaa161.066.Peer-Reviewed Original ResearchEndometrial endometrioid carcinomaMetastatic carcinomaEndometrioid carcinomaNuclear beta-catenin stainingPrimary carcinomaImmunohistochemistry stainingBeta-catenin stainingEndometrioid carcinoma casesRetrospective institutional reviewMedian patient ageCommon metastatic siteBeta-catenin mutationsVariety of tumorsPatient ageMetastatic sitesPR expressionGrade IIIGrade IGrade IIImmunohistochemical profileCarcinoma casesIHC expressionINTRODUCTION/Cancer tumorigenesisCarcinomaDetecting EGFR mutations (L858R, T790M) using allele specific multiplex sequencing: A comparison with Pyrosequencing and TruSeq
Vinayagamoorthy D, Walsh J, Gipson K, Ye F, Zhong M, Dahui Q, Vinayagamoorthy T. Detecting EGFR mutations (L858R, T790M) using allele specific multiplex sequencing: A comparison with Pyrosequencing and TruSeq. Journal Of Solid Tumors 2020, 10: 19. DOI: 10.5430/jst.v10n1p19.Peer-Reviewed Original ResearchEGFR mutationsT790MMultiplex sequencingLate stage lung cancerDetect EGFR mutationsFFPE samplesEGFR somatic mutationsStage lung cancerLow copy numberLung cancer samplesDetect EGFRAnalytical lower limitL858RLung cancerTruSeqCopy numberDetect mutationsPyrosequencingT790EGFRSomatic mutationsCancer samplesMutationsFFPEConcordance
2019
Detecting FLI1 Fusion by Immunohistochemistry (IHC) Stain in Prostatic Adenocarcinoma
Xu K, Budhai A, Pattarkine R, Zhong M. Detecting FLI1 Fusion by Immunohistochemistry (IHC) Stain in Prostatic Adenocarcinoma. American Journal Of Clinical Pathology 2019, 152: s72-s73. DOI: 10.1093/ajcp/aqz113.087.Peer-Reviewed Original ResearchIHC stainsProstate cancerProstatic adenocarcinomaERG fusionNext-generation sequencingProstate adenocarcinoma casesTMA slidesE26 transformation-specific familyCommon genetic alterationsTissue microarray constructionAdenocarcinoma casesIHC stainingImmunohistochemistry stainsPositive casesMRNA level increasesTumor cellsNuclear stainingTCGA dataGenetic alterationsNontumor cellsSection slidesAdenocarcinomaCancerSurrogate testStain
2018
Orbital Lesions: A Retrospective Review From a Single Institute
Salib C, Adem P, Juechter K, Bortz J, Zhong M. Orbital Lesions: A Retrospective Review From a Single Institute. American Journal Of Clinical Pathology 2018, 150: s10-s10. DOI: 10.1093/ajcp/aqy090.023.Peer-Reviewed Original ResearchMarginal zone lymphomaOrbital lesionsRare entityPathological diagnosisAnatomical sitesComputerized tomographyMalignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsExtranodal marginal zone lymphomaRetrospective chart reviewFinal pathological diagnosisMetastatic breast carcinomaNerve sheath tumorsOrbital mass lesionsSquamous cell carcinomaBenign inflammatory conditionGranular cell tumorEpidermal inclusion cystRarity of lesionsChart reviewOrbital pseudotumorRetrospective reviewSheath tumorsSingle instituteSurgical excisionUtility of Pax2 and Bcl-2 Immunohistochemical Stains in Detecting Early Endometrioid Endometrial Carcinoma
Ye Q, Yoon E, Han L, Zhong M. Utility of Pax2 and Bcl-2 Immunohistochemical Stains in Detecting Early Endometrioid Endometrial Carcinoma. American Journal Of Clinical Pathology 2018, 150: s116-s117. DOI: 10.1093/ajcp/aqy098.280.Peer-Reviewed Original ResearchEndometrioid endometrial carcinomaProliferative endometriumWhole tissue sectionsTissue microarrayEndometrial carcinomaSerous carcinomaBcl-2ECC casesSerous carcinoma casesUseful immunohistochemical markerSecretory phase endometriumTissue sectionsTissue section examinationBcl-2 stainingIntensity of stainingBcl-2 expressionNormal endometriumLoss of expressionCarcinoma casesPhase endometriumImmunohistochemical stainsImmunohistochemical markersSection examinationEndometriumIHC stainsA Giant Fibroepithelial Polyp of the Small Bowel Associated with High-Grade Obstruction
Lee H, Sade I, Gilani S, Zhong M, Lombardo G. A Giant Fibroepithelial Polyp of the Small Bowel Associated with High-Grade Obstruction. The American Surgeon 2018, 84: 210-211. PMID: 30401014, DOI: 10.1177/000313481808400701.Peer-Reviewed Original ResearchFrom Bedside to Endoscopy to Microscopy to Diagnosis: Samples Collection and Processing
Yoon E, Zhong M. From Bedside to Endoscopy to Microscopy to Diagnosis: Samples Collection and Processing. 2018, 97-105. DOI: 10.1007/978-3-319-51263-1_9.Peer-Reviewed Original ResearchPathology of Urothelial Malignancies of the Upper Urinary Tract
Hajiyeva S, Zhong M. Pathology of Urothelial Malignancies of the Upper Urinary Tract. 2018, 107-117. DOI: 10.1007/978-3-319-51263-1_10.Peer-Reviewed Original ResearchUpper urinary tractUrothelial carcinomaNoninvasive urothelial carcinomaUrinary tractUpper urinary tract urothelial carcinomaUrinary tract urothelial carcinomaNon-urothelial malignancyInflammatory myofibroblastic tumorInvasive urothelial carcinomaUreteropelvic junction obstructionTumor-like conditionsDiverse treatment optionsIntratubular spreadImmunoglobulin G4Myofibroblastic tumorUrothelial malignancyTreatment optionsGlandular differentiationJunction obstructionRenal pelvisDifferent prognosisRhabdoid tumorMuscular conduitCarcinomaDisease pathology
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