Emily J. Gilmore MD

Assistant Professor of Neurology; Staff Neurointensivist, Neuroscience Intensive Care Unit

Research Interests

Neurocritical care; Neuromonitoring; Multimodality monitoring; Acute stroke; Hypothermia

Current Projects

I am a sub-investigator for the following clinical trials:

GAMES - study of IV glyburide for cerebral edema following acute ischemic stroke

HI-DEF - study of deferoxamine mesylate for intracerebral hemorrhage

ATACH II - study of aggressive blood pressure lowering for intracerebral hemorrhage

CLEAR III - study of intraventricular tPA for intraventricular hemorrhage

DIAS 4 - study of desmoteplase for thrombolysis of acute ischemic stroke

ICTuS 2/3 - study of induced hypothermia in acute ischemic stroke

Research Summary

My research to date has focused on the use of continuous EEG (cEEG) monitoring in patients with severe brain injury, either secondary to a primary brain process or as a manifestions of systemic disease.

My most recent project was a prospective study in Medical ICU patients with severe sepsis who were connected to EEG monitoring. Patients with severe sepsis are at an increased risk of developing frank seizures and abnormal brain wave patterns that represent an increased risk for developing seizures. Our goal was to assess the incidence of seizures and abnormal brain wave patterns as well as the effect of such findings on short and long-term outcomes in this population.

I have also authored chapters on neuromonitoring and have experience with multimodalty monitoring, which involves using information from probes placed in the acutely injured brain of comatose patients to guide medical management.

Currently, I am a site co-investigator for several national clinical trials that are enrolling patients admitted to the Neuroscience ICU with acute ischemic stroke. In addition, I am involved in a study with the Epilepsy Division using a newer antiepileptic (lacosamide) in the treatment of electrographic seizures.

Selected Publications

  • Ong C, Gilmore E, Claassen J, Foreman B, Mayer SA. Impact of prolonged periodic epileptiform discharges on coma prognosis. Neurocrit Care. 2012 Aug;17(1):39-44.
  • Ko SB, Choi HA, Gilmore E, Schmidt JM, Claassen J, Lee K, Mayer SA, Badjatia N. Pearls & Oysters: the effects of renal replacement therapy on cerebral autoregulation. Neurology. 2012 Feb 7;78(6):e36-8.
  • Gilmore E*, Choi HA*, Hirsch LJ, Claassen J. Seizures and CNS Hemorrhage: Spontaneous Intracerebral and Aneurysmal Subarachnoid Hemorrhage. Neurologist. 2010 May;16(3):165-75.
  • Choi HA, Ko SB, Presciutti M, Fernandez L. Carpenter AM, Lesch C, Gilmore E, Malhotra R, Mayer SA, Lee K, Claassen J, Schmidt JM, Badjatia N. Prevention of Shivering during Therapeutic Temperature Modulation: The Columbia Anti-Shivering Protocol. Neurocritical Care. 2011 June; 14(3): 389-9.
  • Choi HA, Ko SB, Chen H, Gilmore E, Carpenter A, Lee D, Claassen J, Mayer SA, Schmidt JM, Lee K, Connelly ES, Paik M, Neeraj Badjatia. Acute Effects of Nimodipine on Cerebral Vasculature and Brain Metabolism. Submitted to Cerebrovascular Diseases.

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