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The quest for personalized medicine, a medical approach in which practitioners use a patient’s unique genetic profile to tailor individual treatment, has emerged as an important goal in the health care sector. But a new Yale-led study shows that the mathematical models currently available to predict treatments have limited effectiveness.

Yale researchers, led by Gustavo A. Angarita, MD, assistant professor of clinical psychiatry, have published a paper in Addiction Biology that explores whether synaptic density in the brain is altered in cocaine use disorder.

Yale Department of Psychiatry scientists have been awarded a five-year, $8.4 million federal grant to establish a new research center at Yale that will develop treatments to help women with problem drinking.

A study of 1.2 million people in the USA has found that people who exercise report having 1.5 fewer days of poor mental health a month, compared to people who do not exercise. The study found that team sports, cycling, aerobics and going to the gym are associated with the biggest reductions, according to the largest observational study of its kind published in The Lancet Psychiatry journal.

John H. Krystal, MD, Robert L. McNeil, Jr. Professor of Neuroscience and Chair of the Yale Department of Psychiatry, is co-author of a study that found evidence ketamine has dose-related antidepressant effects, and that the drug is effective in a Chinese population.

Ralitza Gueorguieva, Ph.D., a senior research scientist in the Department of Biostatistics at the Yale School of Public Health, spent more than two years writing a book on statistical models for correlated data analysis. The book, Statistical Methods in Psychiatry and Related Fields, is being published by CRC Press this month.

Some commercially available e-cigarettes contain enough alcohol to impact motor skills, a new Yale University School of Medicine study shows.

Young people who drink abusively consume less and suffer fewer consequences from alcohol if they take naltrexone, a Yale School of Medicine study shows.

Moderate consumption of alcohol has been associated with health benefits in some — but not all — studies. Researchers at the Yale University School of Medicine may have found an explanation, in part, for why non-smokers might benefit from a glass of wine.