Publications

1.

Arresting a Torsin ATPase reshapes the endoplasmic reticulum.

Rose AE, Zhao C, Turner EM, Steyer AM, Schlieker C.

J Biol Chem. 2014 Jan 3;289 (1) :552-64. Epub 2013 Nov 25. PMID: 24275647

2.

Regulation of Torsin ATPases by LAP1 and LULL1.

Zhao C, Brown RS, Chase AR, Eisele MR, Schlieker C.

Proc Natl Acad Sci U S A. 2013 Apr 23;110 (17) :E1545-54. Epub 2013 Apr 8. PMID: 23569223

3.

A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation.

Sehrawat S, Koenig PA, Kirak O, Schlieker C, Fankhauser M, Ploegh HL.

Blood. 2013 Feb 14;121 (7) :1145-56. Epub 2012 Dec 13. PMID: 23243279

4.

Alternative nuclear transport for cellular protein quality control.

Rose A, Schlieker C.

Trends Cell Biol. 2012 Oct;22 (10) :509-14. Epub 2012 Jul 31. PMID: 22858153

5.

Enzymatic blockade of the ubiquitin-proteasome pathway.

Ernst R, Claessen JH, Mueller B, Sanyal S, Spooner E, van der Veen AG, Kirak O, Schlieker CD, Weihofen WA, Ploegh HL.

PLoS Biol. 2011 Mar;8 (3) :e1000605. Epub 2011 Mar 29. PMID: 21468303

6.

Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.

Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S.

Proc Natl Acad Sci U S A. 2011 Feb 1;108 (5) :1763-70. Epub 2011 Jan 5. PMID: 21209336

7.

DNA repair: Blocking ubiquitin transfer.

Rose A, Schlieker C.

Nature. 2010 Aug 19;466 (7309) :929-30. PMID: 20725029

8.

The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.

Ernst R, Mueller B, Ploegh HL, Schlieker C.

Mol Cell. 2009 Oct 9;36 (1) :28-38. PMID: 19818707

9.

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.

Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL.

Proc Natl Acad Sci U S A. 2008 Nov 25;105 (47) :18255-60. Epub 2008 Nov 18. PMID: 19017811

10.

Mechanisms, biology and inhibitors of deubiquitinating enzymes.

Love KR, Catic A, Schlieker C, Ploegh HL.

Nat Chem Biol. 2007 Nov;3 (11) :697-705. PMID: 17948018

11.

A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection.

Gredmark S, Schlieker C, Quesada V, Spooner E, Ploegh HL.

J Virol. 2007 Oct;81 (19) :10300-9. Epub 2007 Jul 18. PMID: 17634221

12.

Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.

Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL.

Mol Cell. 2007 Mar 9;25 (5) :677-87. PMID: 17349955

13.

A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae.

Schlieker C, Korbel GA, Kattenhorn LM, Ploegh HL.

J Virol. 2005 Dec;79 (24) :15582-5. PMID: 16306630

14.

ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria.

Schlieker C, Zentgraf H, Dersch P, Mogk A.

Biol Chem. 2005 Nov;386 (11) :1115-27. PMID: 16307477

15.

Novel insights into the mechanism of chaperone-assisted protein disaggregation.

Weibezahn J, Schlieker C, Tessarz P, Mogk A, Bukau B.

Biol Chem. 2005 Aug;386 (8) :739-44. PMID: 16201868

16.

Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides.

Schlieker C, Tews I, Bukau B, Mogk A.

FEBS Lett. 2004 Dec 17;578 (3) :351-6. PMID: 15589844

17.

Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

Weibezahn J, Tessarz P, Schlieker C, Zahn R, Maglica Z, Lee S, Zentgraf H, Weber-Ban EU, Dougan DA, Tsai FT, Mogk A, Bukau B.

Cell. 2004 Nov 24;119 (5) :653-65. PMID: 15550247

18.

Substrate recognition by the AAA+ chaperone ClpB.

Schlieker C, Weibezahn J, Patzelt H, Tessarz P, Strub C, Zeth K, Erbse A, Schneider-Mergener J, Chin JW, Schultz PG, Bukau B, Mogk A.

Nat Struct Mol Biol. 2004 Jul;11 (7) :607-15. Epub 2004 Jun 20. PMID: 15208691

19.

A PDZ switch for a cellular stress response.

Schlieker C, Mogk A, Bukau B.

Cell. 2004 May 14;117 (4) :417-9. PMID: 15137934

20.

Broad yet high substrate specificity: the challenge of AAA+ proteins.

Mogk A, Dougan D, Weibezahn J, Schlieker C, Turgay K, Bukau B.

J Struct Biol. 2004 Apr-May;146 (1-2) :90-8. PMID: 15037240

21.

Poly-L-lysine enhances the protein disaggregation activity of ClpB.

Strub C, Schlieker C, Bukau B, Mogk A.

FEBS Lett. 2003 Oct 9;553 (1-2) :125-30. PMID: 14550559

22.

Characterization of a trap mutant of the AAA+ chaperone ClpB.

Weibezahn J, Schlieker C, Bukau B, Mogk A.

J Biol Chem. 2003 Aug 29;278 (35) :32608-17. Epub 2003 Jun 12. PMID: 12805357

23.

Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK.

Mogk A, Schlieker C, Friedrich KL, Schönfeld HJ, Vierling E, Bukau B.

J Biol Chem. 2003 Aug 15;278 (33) :31033-42. Epub 2003 Jun 4. PMID: 12788951

24.

Roles of individual domains and conserved motifs of the AAA+ chaperone ClpB in oligomerization, ATP hydrolysis, and chaperone activity.

Mogk A, Schlieker C, Strub C, Rist W, Weibezahn J, Bukau B.

J Biol Chem. 2003 May 16;278 (20) :17615-24. Epub 2003 Mar 6. PMID: 12624113