The mechanism of Torsin ATPase activation.

Brown RS, Zhao C, Chase AR, Wang J, Schlieker C.

Proc Natl Acad Sci U S A. 2014 Nov 11;111 (45) :E4822-31. Epub 2014 Oct 28. PMID: 25352667


Arresting a Torsin ATPase reshapes the endoplasmic reticulum.

Rose AE, Zhao C, Turner EM, Steyer AM, Schlieker C.

J Biol Chem. 2014 Jan 3;289 (1) :552-64. Epub 2013 Nov 25. PMID: 24275647


Regulation of Torsin ATPases by LAP1 and LULL1.

Zhao C, Brown RS, Chase AR, Eisele MR, Schlieker C.

Proc Natl Acad Sci U S A. 2013 Apr 23;110 (17) :E1545-54. Epub 2013 Apr 8. PMID: 23569223


A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation.

Sehrawat S, Koenig PA, Kirak O, Schlieker C, Fankhauser M, Ploegh HL.

Blood. 2013 Feb 14;121 (7) :1145-56. Epub 2012 Dec 13. PMID: 23243279


Alternative nuclear transport for cellular protein quality control.

Rose A, Schlieker C.

Trends Cell Biol. 2012 Oct;22 (10) :509-14. Epub 2012 Jul 31. PMID: 22858153


Enzymatic blockade of the ubiquitin-proteasome pathway.

Ernst R, Claessen JH, Mueller B, Sanyal S, Spooner E, van der Veen AG, Kirak O, Schlieker CD, Weihofen WA, Ploegh HL.

PLoS Biol. 2011 Mar;8 (3) :e1000605. Epub 2011 Mar 29. PMID: 21468303


Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.

Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S.

Proc Natl Acad Sci U S A. 2011 Feb 1;108 (5) :1763-70. Epub 2011 Jan 5. PMID: 21209336


DNA repair: Blocking ubiquitin transfer.

Rose A, Schlieker C.

Nature. 2010 Aug 19;466 (7309) :929-30. PMID: 20725029


The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.

Ernst R, Mueller B, Ploegh HL, Schlieker C.

Mol Cell. 2009 Oct 9;36 (1) :28-38. PMID: 19818707


A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.

Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL.

Proc Natl Acad Sci U S A. 2008 Nov 25;105 (47) :18255-60. Epub 2008 Nov 18. PMID: 19017811


Mechanisms, biology and inhibitors of deubiquitinating enzymes.

Love KR, Catic A, Schlieker C, Ploegh HL.

Nat Chem Biol. 2007 Nov;3 (11) :697-705. PMID: 17948018


A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection.

Gredmark S, Schlieker C, Quesada V, Spooner E, Ploegh HL.

J Virol. 2007 Oct;81 (19) :10300-9. Epub 2007 Jul 18. PMID: 17634221


Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.

Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL.

Mol Cell. 2007 Mar 9;25 (5) :677-87. PMID: 17349955


A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae.

Schlieker C, Korbel GA, Kattenhorn LM, Ploegh HL.

J Virol. 2005 Dec;79 (24) :15582-5. PMID: 16306630


ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria.

Schlieker C, Zentgraf H, Dersch P, Mogk A.

Biol Chem. 2005 Nov;386 (11) :1115-27. PMID: 16307477


Novel insights into the mechanism of chaperone-assisted protein disaggregation.

Weibezahn J, Schlieker C, Tessarz P, Mogk A, Bukau B.

Biol Chem. 2005 Aug;386 (8) :739-44. PMID: 16201868


Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides.

Schlieker C, Tews I, Bukau B, Mogk A.

FEBS Lett. 2004 Dec 17;578 (3) :351-6. PMID: 15589844


Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

Weibezahn J, Tessarz P, Schlieker C, Zahn R, Maglica Z, Lee S, Zentgraf H, Weber-Ban EU, Dougan DA, Tsai FT, Mogk A, Bukau B.

Cell. 2004 Nov 24;119 (5) :653-65. PMID: 15550247


Substrate recognition by the AAA+ chaperone ClpB.

Schlieker C, Weibezahn J, Patzelt H, Tessarz P, Strub C, Zeth K, Erbse A, Schneider-Mergener J, Chin JW, Schultz PG, Bukau B, Mogk A.

Nat Struct Mol Biol. 2004 Jul;11 (7) :607-15. Epub 2004 Jun 20. PMID: 15208691


A PDZ switch for a cellular stress response.

Schlieker C, Mogk A, Bukau B.

Cell. 2004 May 14;117 (4) :417-9. PMID: 15137934


Broad yet high substrate specificity: the challenge of AAA+ proteins.

Mogk A, Dougan D, Weibezahn J, Schlieker C, Turgay K, Bukau B.

J Struct Biol. 2004 Apr-May;146 (1-2) :90-8. PMID: 15037240


Poly-L-lysine enhances the protein disaggregation activity of ClpB.

Strub C, Schlieker C, Bukau B, Mogk A.

FEBS Lett. 2003 Oct 9;553 (1-2) :125-30. PMID: 14550559


Characterization of a trap mutant of the AAA+ chaperone ClpB.

Weibezahn J, Schlieker C, Bukau B, Mogk A.

J Biol Chem. 2003 Aug 29;278 (35) :32608-17. Epub 2003 Jun 12. PMID: 12805357


Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK.

Mogk A, Schlieker C, Friedrich KL, Schönfeld HJ, Vierling E, Bukau B.

J Biol Chem. 2003 Aug 15;278 (33) :31033-42. Epub 2003 Jun 4. PMID: 12788951


Roles of individual domains and conserved motifs of the AAA+ chaperone ClpB in oligomerization, ATP hydrolysis, and chaperone activity.

Mogk A, Schlieker C, Strub C, Rist W, Weibezahn J, Bukau B.

J Biol Chem. 2003 May 16;278 (20) :17615-24. Epub 2003 Mar 6. PMID: 12624113