Welcome to the Rothman Lab

Membrane fusion is a fundamental biological process for organelle formation, nutrient uptake, and the secretion of hormones and neurotransmitters.

It is central to vesicular transport, storage, and release in many areas of endocrine and exocrine physiology, and imbalances in these processes give rise to important diseases, such as diabetes.

We employ diverse biophysical, biochemical, and cell biological approaches to characterize the fundamental participants in intracellular transport processes.

Research in the Rothman Lab

Over 30 years ago, we observed what we interpreted to be vesicular transport in crude extracts of tissue culture cells. In subsequent years we found...

Principal Investigator

James E Rothman, PhD

Fergus F. Wallace Professor of Cell Biology and Professor of Chemistry


Contact Info
Rothman Laboratory
Sterling Hall of Medicine, C-Wing
333 Cedar Street
New Haven, CT 06510

All invitations for lectures or appearances, other than scholarly ones, should be directed to
The Leigh Bureau:
William Leigh