Publications

Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M and Kwong PD: Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014 Oct 23;514 (7523) :455-61. Epub 2014 Oct 8. PMID: 25296255


Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB 3rd, Kwong PD, Blanchard SC and Mothes W: Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science. 2014 Oct 8; Epub 2014 Oct 8. PMID: 25298114


Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA and Mothes W: TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly. J Cell Sci. 2014 Sep 15;127 (Pt 18) :3928-42. Epub 2014 Jul 11. PMID: 25015296


Li F, Sewald X, Jin J, Sherer NM and Mothes W: Murine leukemia virus Gag localizes to the uropod of migrating primary lymphocytes. J Virol. 2014 Sep;88 (18) :10541-55. Epub 2014 Jun 25. PMID: 24965475


Munro JB and Mothes W: The HIV-1 Env trimer in HD. Structure. 2014 Jul 8;22 (7) :935-6. PMID: 25007222


Munro JB, Nath A, Färber M, Datta SA, Rein A, Rhoades E and Mothes W: A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol. 2014 Mar;88 (6) :3577-85. Epub 2014 Jan 8. PMID: 24403576


Agosto LM, Zhong P, Munro J and Mothes W: Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission. PLoS Pathog. 2014 Feb;10 (2) :e1003982. Epub 2014 Feb 27. PMID: 24586176

Huang F, Hartwich TM, Rivera-Molina FE, Lin Y, Duim WC, Long JJ, Uchil PD, Myers JR, Baird MA, Mothes W, Davidson MW, Toomre D and Bewersdorf J: Video-rate nanoscopy using sCMOS camera-specific single-molecule localization algorithms. Nat Methods. 2013 Jul;10 (7) :653-8. Epub 2013 May 26. PMID: 23708387


Li F, Jin J, Herrmann C and Mothes W: Basic residues in the matrix domain and multimerization target murine leukemia virus Gag to the virological synapse. J Virol. 2013 Jun;87 (12) :7113-26. Epub 2013 Apr 24. PMID: 23616653


Zhong P, Agosto LM, Munro JB and Mothes W: Cell-to-cell transmission of viruses. Curr Opin Virol. 2013 Feb;3 (1) :44-50. Epub 2012 Dec 5. PMID: 23219376


Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J and Mothes W: TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. J Virol. 2013 Jan;87 (1) :257-72. Epub 2012 Oct 17. PMID: 23077300


Garcia ML, Reynolds TD, Mothes W and Robek MD: Functional characterization of the putative hepatitis B virus core protein late domain using retrovirus chimeras. PLoS One. 2013;8 (8) :e72845. Epub 2013 Aug 29. PMID: 24009707


Zhong P, Agosto LM, Ilinskaya A, Dorjbal B, Truong R, Derse D, Uchil PD, Heidecker G and Mothes W: Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV. PLoS One. 2013;8 (1) :e53138. Epub 2013 Jan 7. PMID: 23308151

Sewald X, Gonzalez DG, Haberman AM and Mothes W: In vivo imaging of virological synapses. Nat Commun. 2012;3 :1320. PMID: 23271654

Jin J, Li F and Mothes W: Viral determinants of polarized assembly for the murine leukemia virus. J Virol. 2011 Aug;85 (15) :7672-82. Epub 2011 May 18. PMID: 21593177


Kajaste-Rudnitski A, Marelli SS, Pultrone C, Pertel T, Uchil PD, Mechti N, Mothes W, Poli G, Luban J and Vicenzi E: TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements. J Virol. 2011 May;85 (10) :5183-96. Epub 2011 Feb 23. PMID: 21345949


Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Grütter MG and Luban J: TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature. 2011 Apr 21;472 (7343) :361-5. PMID: 21512573

Mothes W, Sherer NM, Jin J and Zhong P: Virus cell-to-cell transmission. J Virol. 2010 Sep;84 (17) :8360-8. Epub 2010 Apr 7. PMID: 20375157


Sherer NM, Jin J and Mothes W: Directional spread of surface-associated retroviruses regulated by differential virus-cell interactions. J Virol. 2010 Apr;84 (7) :3248-58. Epub 2010 Jan 20. PMID: 20089647


Jin J, Sherer N and Mothes W: Surface Transmission or Polarized Egress? Lessons Learned from HTLV Cell-to-Cell Transmission. Viruses. 2010 Feb;2 (2) :601-5. Epub 2010 Feb 10. PMID: 21994650

Jin J, Sturgeon T, Weisz OA, Mothes W and Montelaro RC: HIV-1 matrix dependent membrane targeting is regulated by Gag mRNA trafficking. PLoS One. 2009 Aug 7;4 (8) :e6551. Epub 2009 Aug 7. PMID: 19662089


Jin J, Sherer NM, Heidecker G, Derse D and Mothes W: Assembly of the murine leukemia virus is directed towards sites of cell-cell contact. PLoS Biol. 2009 Jul;7 (7) :e1000163. Epub 2009 Jul 28. PMID: 19636361


Uchil PD and Mothes W: HIV Entry Revisited. Cell. 2009 May 1;137 (3) :402-4. PMID: 19410537


Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F and Greene WC: The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J Virol. 2009 Jan;83 (1) :73-80. Epub 2008 Oct 22. PMID: 18945786


Carthagena L, Bergamaschi A, Luna JM, David A, Uchil PD, Margottin-Goguet F, Mothes W, Hazan U, Transy C, Pancino G and Nisole S: Human TRIM gene expression in response to interferons. PLoS One. 2009;4 (3) :e4894. Epub 2009 Mar 17. PMID: 19290053

Chan R, Uchil PD, Jin J, Shui G, Ott DE, Mothes W and Wenk MR: Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides. J Virol. 2008 Nov;82 (22) :11228-38. Epub 2008 Sep 17. PMID: 18799574


Sherer NM and Mothes W: Cytonemes and tunneling nanotubules in cell-cell communication and viral pathogenesis. Trends Cell Biol. 2008 Sep;18 (9) :414-20. Epub 2008 Aug 14. PMID: 18703335


Chan WT, Sherer NM, Uchil PD, Novak EK, Swank RT and Mothes W: Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis. PLoS One. 2008 Jul 16;3 (7) :e2713. Epub 2008 Jul 16. PMID: 18629000


Uchil PD, Quinlan BD, Chan WT, Luna JM and Mothes W: TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. PLoS Pathog. 2008 Feb 8;4 (2) :e16. PMID: 18248090

Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG and Kirchhoff F: Semen-derived amyloid fibrils drastically enhance HIV infection. Cell. 2007 Dec 14;131 (6) :1059-71. PMID: 18083097


Stahl S, Reinders Y, Asan E, Mothes W, Conzelmann E, Sickmann A and Felbor U: Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes. Biochim Biophys Acta. 2007 Oct;1774 (10) :1237-46. Epub 2007 Jul 19. PMID: 17765022


Sherer NM, Lehmann MJ, Jimenez-Soto LF, Horensavitz C, Pypaert M and Mothes W: Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nat Cell Biol. 2007 Mar;9 (3) :310-5. Epub 2007 Feb 11. PMID: 17293854

Czibener C, Sherer NM, Becker SM, Pypaert M, Hui E, Chapman ER, Mothes W and Andrews NW: Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes. J Cell Biol. 2006 Sep 25;174 (7) :997-1007. Epub 2006 Sep 18. PMID: 16982801

Lehmann MJ, Sherer NM, Marks CB, Pypaert M and Mothes W: Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells. J Cell Biol. 2005 Jul 18;170 (2) :317-25. PMID: 16027225


Uchil P and Mothes W: Viral entry: a detour through multivesicular bodies. Nat Cell Biol. 2005 Jul;7 (7) :641-2. PMID: 15990891


Melikyan GB, Barnard RJ, Abrahamyan LG, Mothes W and Young JA: Imaging individual retroviral fusion events: from hemifusion to pore formation and growth. Proc Natl Acad Sci U S A. 2005 Jun 14;102 (24) :8728-33. Epub 2005 Jun 3. PMID: 15937118

Sherer NM, Lehmann MJ, Jimenez-Soto LF, Ingmundson A, Horner SM, Cicchetti G, Allen PG, Pypaert M, Cunningham JM and Mothes W: Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. Traffic. 2003 Nov;4 (11) :785-801. PMID: 14617360

Felbor U, Kessler B, Mothes W, Goebel HH, Ploegh HL, Bronson RT and Olsen BR: Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A. 2002 Jun 11;99 (12) :7883-8. Epub 2002 Jun 4. PMID: 12048238

Mothes W, Boerger AL, Narayan S, Cunningham JM and Young JA: Retroviral entry mediated by receptor priming and low pH triggering of an envelope glycoprotein. Cell. 2000 Nov 10;103 (4) :679-89. PMID: 11106737