Publications

Do Kwon Y, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD: Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nat Struct Mol Biol. 2015 Jul; 2015 Jun 22. PMID: 26098315

Munro JB, Mothes W: Structure and Dynamics of the Native HIV-1 Env Trimer. J Virol. 2015 Jun; 2015 Mar 11. PMID: 25762739

Agosto LM, Uchil PD, Mothes W: HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy. Trends Microbiol. 2015 May; 2015 Mar 9. PMID: 25766144

Zeller S, Choi CS, Uchil PD, Ban HS, Siefert A, Fahmy TM, Mothes W, Lee SK, Kumar P: Attachment of cell-binding ligands to arginine-rich cell-penetrating peptides enables cytosolic translocation of complexed siRNA. Chem Biol. 2015 Jan 22; 2014 Dec 24. PMID: 25544044

Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB 3rd, Kwong PD, Blanchard SC, Mothes W: Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science. 2014 Nov 7; 2014 Oct 8. PMID: 25298114

Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD: Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014 Oct 23; 2014 Oct 8. PMID: 25296255

Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA, Mothes W: TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly. J Cell Sci. 2014 Sep 15; 2014 Jul 11. PMID: 25015296

Li F, Sewald X, Jin J, Sherer NM, Mothes W: Murine leukemia virus Gag localizes to the uropod of migrating primary lymphocytes. J Virol. 2014 Sep; 2014 Jun 25. PMID: 24965475

Munro JB, Mothes W: The HIV-1 Env trimer in HD. Structure. 2014 Jul 8. PMID: 25007222

Munro JB, Nath A, Färber M, Datta SA, Rein A, Rhoades E, Mothes W: A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol. 2014 Mar; 2014 Jan 8. PMID: 24403576

Agosto LM, Zhong P, Munro J, Mothes W: Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission. PLoS Pathog. 2014 Feb; 2014 Feb 27. PMID: 24586176

Huang F, Hartwich TM, Rivera-Molina FE, Lin Y, Duim WC, Long JJ, Uchil PD, Myers JR, Baird MA, Mothes W, Davidson MW, Toomre D, Bewersdorf J: Video-rate nanoscopy using sCMOS camera-specific single-molecule localization algorithms. Nat Methods. 2013 Jul; 2013 May 26. PMID: 23708387

Li F, Jin J, Herrmann C, Mothes W: Basic residues in the matrix domain and multimerization target murine leukemia virus Gag to the virological synapse. J Virol. 2013 Jun; 2013 Apr 24. PMID: 23616653

Zhong P, Agosto LM, Munro JB, Mothes W: Cell-to-cell transmission of viruses. Curr Opin Virol. 2013 Feb; 2012 Dec 5. PMID: 23219376

Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J, Mothes W: TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. J Virol. 2013 Jan; 2012 Oct 17. PMID: 23077300

Garcia ML, Reynolds TD, Mothes W, Robek MD: Functional characterization of the putative hepatitis B virus core protein late domain using retrovirus chimeras. PLoS One. 2013; 2013 Aug 29. PMID: 24009707

Zhong P, Agosto LM, Ilinskaya A, Dorjbal B, Truong R, Derse D, Uchil PD, Heidecker G, Mothes W: Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV. PLoS One. 2013; 2013 Jan 7. PMID: 23308151

Sewald X, Gonzalez DG, Haberman AM, Mothes W: In vivo imaging of virological synapses. Nat Commun. 2012. PMID: 23271654

Jin J, Li F, Mothes W: Viral determinants of polarized assembly for the murine leukemia virus. J Virol. 2011 Aug; 2011 May 18. PMID: 21593177

Kajaste-Rudnitski A, Marelli SS, Pultrone C, Pertel T, Uchil PD, Mechti N, Mothes W, Poli G, Luban J, Vicenzi E: TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements. J Virol. 2011 May; 2011 Feb 23. PMID: 21345949

Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Grütter MG, Luban J: TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature. 2011 Apr 21. PMID: 21512573

Mothes W, Sherer NM, Jin J, Zhong P: Virus cell-to-cell transmission. J Virol. 2010 Sep; 2010 Apr 7. PMID: 20375157

Sherer NM, Jin J, Mothes W: Directional spread of surface-associated retroviruses regulated by differential virus-cell interactions. J Virol. 2010 Apr; 2010 Jan 20. PMID: 20089647

Jin J, Sherer N, Mothes W: Surface Transmission or Polarized Egress? Lessons Learned from HTLV Cell-to-Cell Transmission. Viruses. 2010 Feb; 2010 Feb 10. PMID: 21994650

Jin J, Sturgeon T, Weisz OA, Mothes W, Montelaro RC: HIV-1 matrix dependent membrane targeting is regulated by Gag mRNA trafficking. PLoS One. 2009 Aug 7; 2009 Aug 7. PMID: 19662089

Jin J, Sherer NM, Heidecker G, Derse D, Mothes W: Assembly of the murine leukemia virus is directed towards sites of cell-cell contact. PLoS Biol. 2009 Jul; 2009 Jul 28. PMID: 19636361

Uchil PD, Mothes W: HIV Entry Revisited. Cell. 2009 May 1. PMID: 19410537

Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC: The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J Virol. 2009 Jan; 2008 Oct 22. PMID: 18945786

Carthagena L, Bergamaschi A, Luna JM, David A, Uchil PD, Margottin-Goguet F, Mothes W, Hazan U, Transy C, Pancino G, Nisole S: Human TRIM gene expression in response to interferons. PLoS One. 2009; 2009 Mar 17. PMID: 19290053

Chan R, Uchil PD, Jin J, Shui G, Ott DE, Mothes W, Wenk MR: Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides. J Virol. 2008 Nov; 2008 Sep 17. PMID: 18799574

Sherer NM, Mothes W: Cytonemes and tunneling nanotubules in cell-cell communication and viral pathogenesis. Trends Cell Biol. 2008 Sep; 2008 Aug 14. PMID: 18703335

Chan WT, Sherer NM, Uchil PD, Novak EK, Swank RT, Mothes W: Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis. PLoS One. 2008 Jul 16; 2008 Jul 16. PMID: 18629000

Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W: TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. PLoS Pathog. 2008 Feb 8. PMID: 18248090

Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG, Kirchhoff F: Semen-derived amyloid fibrils drastically enhance HIV infection. Cell. 2007 Dec 14. PMID: 18083097

Stahl S, Reinders Y, Asan E, Mothes W, Conzelmann E, Sickmann A, Felbor U: Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes. Biochim Biophys Acta. 2007 Oct; 2007 Jul 19. PMID: 17765022

Sherer NM, Lehmann MJ, Jimenez-Soto LF, Horensavitz C, Pypaert M, Mothes W: Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nat Cell Biol. 2007 Mar; 2007 Feb 11. PMID: 17293854

Czibener C, Sherer NM, Becker SM, Pypaert M, Hui E, Chapman ER, Mothes W, Andrews NW: Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes. J Cell Biol. 2006 Sep 25; 2006 Sep 18. PMID: 16982801

Lehmann MJ, Sherer NM, Marks CB, Pypaert M, Mothes W: Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells. J Cell Biol. 2005 Jul 18. PMID: 16027225

Uchil P, Mothes W: Viral entry: a detour through multivesicular bodies. Nat Cell Biol. 2005 Jul. PMID: 15990891

Melikyan GB, Barnard RJ, Abrahamyan LG, Mothes W, Young JA: Imaging individual retroviral fusion events: from hemifusion to pore formation and growth. Proc Natl Acad Sci U S A. 2005 Jun 14; 2005 Jun 3. PMID: 15937118

Sherer NM, Lehmann MJ, Jimenez-Soto LF, Ingmundson A, Horner SM, Cicchetti G, Allen PG, Pypaert M, Cunningham JM, Mothes W: Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. Traffic. 2003 Nov. PMID: 14617360

Felbor U, Kessler B, Mothes W, Goebel HH, Ploegh HL, Bronson RT, Olsen BR: Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A. 2002 Jun 11; 2002 Jun 4. PMID: 12048238

Mothes W, Boerger AL, Narayan S, Cunningham JM, Young JA: Retroviral entry mediated by receptor priming and low pH triggering of an envelope glycoprotein. Cell. 2000 Nov 10. PMID: 11106737