Recent Publications

Simonds SE, Pryor JT, Ravussin E, Greenway FL, Dileone R, Allen AM, Bassi J, Elmquist JK, Keogh JM, Henning E, Myers MG Jr, Licinio J, Brown RD, Enriori PJ, O'Rahilly S, Sternson SM, Grove KL, Spanswick DC, Farooqi IS and Cowley MA: Leptin mediates the increase in blood pressure associated with obesity. Cell. 2014 Dec 4;159 (6) :1404-16. PMID: 25480301


Taylor SR, Badurek S, Dileone RJ, Nashmi R, Minichiello L and Picciotto MR: GABAergic and glutamatergic efferents of the mouse ventral tegmental area. J Comp Neurol. 2014 Oct 1;522 (14) :3308-34. PMID: 24715505


Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, DiLeone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS and Luquet S: Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry. 2014 Oct;19 (10) :1095-105. Epub 2014 Apr 15. PMID: 24732670


Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK and Diano S: Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proc Natl Acad Sci U S A. 2014 Aug 12;111 (32) :11876-81. Epub 2014 Jul 28. PMID: 25071172


van den Heuvel JK, Furman K, Gumbs MC, Eggels L, Opland DM, Land BB, Kolk SM, Narayanan N, Fliers E, Kalsbeek A, DiLeone RJ and la Fleur SE: Neuropeptide Y Activity in the Nucleus Accumbens Modulates Feeding Behavior and Neuronal Activity. Biol Psychiatry. 2014 Jun 18; Epub 2014 Jun 18. PMID: 25109664


Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK and Duman RS: REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nat Med. 2014 May;20 (5) :531-5. Epub 2014 Apr 13. PMID: 24728411


Udo T, Weinberger AH, Grilo CM, Brownell KD, DiLeone RJ, Lampert R, Matlin SL, Yanagisawa K and McKee SA: Heightened vagal activity during high-calorie food presentation in obese compared with non-obese individuals--results of a pilot study. Obes Res Clin Pract. 2014 May-Jun;8 (3) :e201-98. PMID: 24847667


Maldonado-Avilés JG and Dileone RJ: Inhaling: endocannabinoids and food intake. Nat Neurosci. 2014 Mar;17 (3) :336-7. PMID: 24569827


Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, Grimaldi DM, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK and DiLeone RJ: Medial prefrontal D1 dopamine neurons control food intake. Nat Neurosci. 2014 Feb;17 (2) :248-53. Epub 2014 Jan 19. PMID: 24441680


Arendt DH, Hassell J, Li H, Achua JK, Guarnieri DJ, Dileone RJ, Ronan PJ and Summers CH: Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala. Psychoneuroendocrinology. 2014 Feb;40 :17-26. Epub 2013 Oct 30. PMID: 24485472


Land BB, Brayton CE, Furman KE, Lapalombara Z and Dileone RJ: Optogenetic inhibition of neurons by internal light production. Front Behav Neurosci. 2014;8 :108. Epub 2014 Apr 1. PMID: 24744708


Anastasio NC, Stutz SJ, Fox RG, Sears RM, Emeson RB, DiLeone RJ, O'Neil RT, Fink LH, Li D, Green TA, Moeller FG and Cunningham KA: Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence. Neuropsychopharmacology. 2014 Jan;39 (2) :370-82. Epub 2013 Aug 13. PMID: 23939424

Gourley SL, Olevska A, Zimmermann KS, Ressler KJ, Dileone RJ and Taylor JR: The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum. Eur J Neurosci. 2013 Aug;38 (3) :2382-8. Epub 2013 May 8. PMID: 23651226


Sarhan M, Pawlowski SA, Barthas F, Yalcin I, Kaufling J, Dardente H, Zachariou V, Dileone RJ, Barrot M and Veinante P: BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia. Int J Neuropsychopharmacol. 2013 Aug;16 (7) :1649-60. Epub 2013 Feb 21. PMID: 23425507


Tellez LA, Ferreira JG, Medina S, Land BB, DiLeone RJ and de Araujo IE: Flavor-independent maintenance, extinction, and reinstatement of fat self-administration in mice. Biol Psychiatry. 2013 May 1;73 (9) :851-9. PMID: 23587200


Udo T, Grilo CM, Brownell KD, Weinberger AH, Dileone RJ and McKee SA: Modeling the effects of positive and negative mood on the ability to resist eating in obese and non-obese individuals. Eat Behav. 2013 Jan;14 (1) :40-6. Epub 2012 Oct 31. PMID: 23265400


Guarnieri DJ and DiLeone RJ: Transcriptional plasticity in the brain following metabolic challenge. Neuropsychopharmacology. 2013 Jan;38 (1) :237-8. PMID: 23147479

Narayanan NS, Land BB, Solder JE, Deisseroth K and DiLeone RJ: Prefrontal D1 dopamine signaling is required for temporal control. Proc Natl Acad Sci U S A. 2012 Dec 11;109 (50) :20726-31. Epub 2012 Nov 26. PMID: 23185016


Gourley SL, Swanson AM, Jacobs AM, Howell JL, Mo M, Dileone RJ, Koleske AJ and Taylor JR: Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Proc Natl Acad Sci U S A. 2012 Dec 11;109 (50) :20714-9. Epub 2012 Nov 26. PMID: 23185000


DiLeone RJ, Taylor JR and Picciotto MR: The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction. Nat Neurosci. 2012 Oct;15 (10) :1330-5. Epub 2012 Sep 25. PMID: 23007187


Kanoski SE, Zhao S, Guarnieri DJ, DiLeone RJ, Yan J, De Jonghe BC, Bence KK, Hayes MR and Grill HJ: Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. Am J Physiol Endocrinol Metab. 2012 Aug 15;303 (4) :E496-503. Epub 2012 Jun 12. PMID: 22693203


Land BB and DiLeone RJ: Losing the lust for life: a new role for an old feeding Peptide? Neuron. 2012 Aug 9;75 (3) :360-2. PMID: 22884320


D'Sa C, Dileone RJ, Anderson GM and Sinha R: Serum and plasma brain-derived neurotrophic factor (BDNF) in abstinent alcoholics and social drinkers. Alcohol. 2012 May;46 (3) :253-9. Epub 2012 Feb 22. PMID: 22364688


Guarnieri DJ, Brayton CE, Richards SM, Maldonado-Aviles J, Trinko JR, Nelson J, Taylor JR, Gourley SL and DiLeone RJ: Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction. Biol Psychiatry. 2012 Feb 15;71 (4) :358-65. PMID: 21855858

D'Sa C, Fox HC, Hong AK, Dileone RJ and Sinha R: Increased serum brain-derived neurotrophic factor is predictive of cocaine relapse outcomes: a prospective study. Biol Psychiatry. 2011 Oct 15;70 (8) :706-11. Epub 2011 Jul 8. PMID: 21741029


Gearhardt AN, Grilo CM, DiLeone RJ, Brownell KD and Potenza MN: Can food be addictive? Public health and policy implications. Addiction. 2011 Jul;106 (7) :1208-12. Epub 2011 Feb 14. PMID: 21635588


Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB and Picciotto MR: Nicotine decreases food intake through activation of POMC neurons. Science. 2011 Jun 10;332 (6035) :1330-2. PMID: 21659607


Mul JD, la Fleur SE, Toonen PW, Afrasiab-Middelman A, Binnekade R, Schetters D, Verheij MM, Sears RM, Homberg JR, Schoffelmeer AN, Adan RA, DiLeone RJ, De Vries TJ and Cuppen E: Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat. PLoS One. 2011 May 5;6 (5) :e19600. Epub 2011 May 5. PMID: 21573180


DiLeone RJ: Neuroscience gets nutrition. Nat Neurosci. 2011 Mar;14 (3) :271-2. PMID: 21346742


Trinko R, Gan G, Gao XB, Sears RM, Guarnieri DJ and DiLeone RJ: Erk1/2 mediates leptin receptor signaling in the ventral tegmental area. PLoS One. 2011;6 (11) :e27180. Epub 2011 Nov 4. PMID: 22076135


Ploski JE, Monsey MS, Nguyen T, DiLeone RJ and Schafe GE: The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories. PLoS One. 2011;6 (8) :e23760. Epub 2011 Aug 22. PMID: 21887312

Mukherjee S, Coque L, Cao JL, Kumar J, Chakravarty S, Asaithamby A, Graham A, Gordon E, Enwright JF 3rd, DiLeone RJ, Birnbaum SG, Cooper DC and McClung CA: Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior. Biol Psychiatry. 2010 Sep 15;68 (6) :503-11. Epub 2010 Jun 29. PMID: 20591414


Okamoto H, Voleti B, Banasr M, Sarhan M, Duric V, Girgenti MJ, Dileone RJ, Newton SS and Duman RS: Wnt2 expression and signaling is increased by different classes of antidepressant treatments. Biol Psychiatry. 2010 Sep 15;68 (6) :521-7. Epub 2010 Jun 8. PMID: 20570247


Sears RM, Liu RJ, Narayanan NS, Sharf R, Yeckel MF, Laubach M, Aghajanian GK and DiLeone RJ: Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone. J Neurosci. 2010 Jun 16;30 (24) :8263-73. PMID: 20554878


Sharf R, Sarhan M, Brayton CE, Guarnieri DJ, Taylor JR and DiLeone RJ: Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement. Biol Psychiatry. 2010 Apr 15;67 (8) :753-60. Epub 2010 Feb 26. PMID: 20189166


Sharf R, Guarnieri DJ, Taylor JR and DiLeone RJ: Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization. Brain Res. 2010 Mar 4;1317 :24-32. Epub 2009 Dec 23. PMID: 20034477


Sharf R, Sarhan M and Dileone RJ: Role of orexin/hypocretin in dependence and addiction. Brain Res. 2010 Feb 16;1314 :130-8. Epub 2009 Aug 20. PMID: 19699189


Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK and Grill HJ: Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab. 2010 Jan;11 (1) :77-83. PMID: 20074530


Narayanan NS, Guarnieri DJ and DiLeone RJ: Metabolic hormones, dopamine circuits, and feeding. Front Neuroendocrinol. 2010 Jan;31 (1) :104-12. Epub 2009 Oct 28. PMID: 19836414

Gourley SL, Howell JL, Rios M, DiLeone RJ and Taylor JR: Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. Learn Mem. 2009 Dec;16 (12) :756-60. Epub 2009 Nov 19. PMID: 19926781


Berton O, Guigoni C, Li Q, Bioulac BH, Aubert I, Gross CE, Dileone RJ, Nestler EJ and Bezard E: Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease. Biol Psychiatry. 2009 Sep 15;66 (6) :554-61. Epub 2009 May 28. PMID: 19481198


Winstanley CA, Green TA, Theobald DE, Renthal W, LaPlant Q, DiLeone RJ, Chakravarty S and Nestler EJ: DeltaFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine. Pharmacol Biochem Behav. 2009 Sep;93 (3) :278-84. Epub 2008 Dec 16. PMID: 19135469


DiLeone RJ: Leptin: taking the path less traveled. Cell Metab. 2009 Aug;10 (2) :77-8. PMID: 19656482


DiLeone RJ: The influence of leptin on the dopamine system and implications for ingestive behavior. Int J Obes (Lond). 2009 Jun;33 Suppl 2 :S25-9. PMID: 19528975


Graham DL, Krishnan V, Larson EB, Graham A, Edwards S, Bachtell RK, Simmons D, Gent LM, Berton O, Bolanos CA, DiLeone RJ, Parada LF, Nestler EJ and Self DW: Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol Psychiatry. 2009 Apr 15;65 (8) :696-701. Epub 2008 Nov 6. PMID: 18990365


Simen AA, DiLeone R and Arnsten AF: Primate models of schizophrenia: future possibilities. Prog Brain Res. 2009;179 :117-25. Epub 2009 Nov 20. PMID: 20302824

Wallace DL, Vialou V, Rios L, Carle-Florence TL, Chakravarty S, Kumar A, Graham DL, Green TA, Kirk A, Iñiguez SD, Perrotti LI, Barrot M, DiLeone RJ, Nestler EJ and Bolaños-Guzmán CA: The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior. J Neurosci. 2008 Oct 8;28 (41) :10272-7. PMID: 18842886


Sharf R, Sarhan M and Dileone RJ: Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell. Biol Psychiatry. 2008 Aug 1;64 (3) :175-83. Epub 2008 Apr 18. PMID: 18423425


Guarnieri DJ and DiLeone RJ: MicroRNAs: a new class of gene regulators. Ann Med. 2008;40 (3) :197-208. PMID: 18382885

Benavides DR, Quinn JJ, Zhong P, Hawasli AH, DiLeone RJ, Kansy JW, Olausson P, Yan Z, Taylor JR and Bibb JA: Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability. J Neurosci. 2007 Nov 21;27 (47) :12967-76. PMID: 18032670


Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, DiLeone RJ, Greer CA, Mandyam CD and Eisch AJ: Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci. 2007 Nov 14;27 (46) :12623-9. PMID: 18003841


Winstanley CA, LaPlant Q, Theobald DE, Green TA, Bachtell RK, Perrotti LI, DiLeone RJ, Russo SJ, Garth WJ, Self DW and Nestler EJ: DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J Neurosci. 2007 Sep 26;27 (39) :10497-507. PMID: 17898221


Trinko R, Sears RM, Guarnieri DJ and DiLeone RJ: Neural mechanisms underlying obesity and drug addiction. Physiol Behav. 2007 Aug 15;91 (5) :499-505. Epub 2007 Jan 16. PMID: 17292426


Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M and Self DW: Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat Neurosci. 2007 Aug;10 (8) :1029-37. Epub 2007 Jul 8. PMID: 17618281

de Lecea L, Jones BE, Boutrel B, Borgland SL, Nishino S, Bubser M and DiLeone R: Addiction and arousal: alternative roles of hypothalamic peptides. J Neurosci. 2006 Oct 11;26 (41) :10372-5. PMID: 17035520


Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M and DiLeone RJ: Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron. 2006 Sep 21;51 (6) :801-10. PMID: 16982424


Green TA, Alibhai IN, Hommel JD, DiLeone RJ, Kumar A, Theobald DE, Neve RL and Nestler EJ: Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. J Neurosci. 2006 Aug 9;26 (32) :8235-42. PMID: 16899718


Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW and Nestler EJ: Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006 Feb 10;311 (5762) :864-8. PMID: 16469931


Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A and Nestler EJ: An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci. 2006 Feb;9 (2) :205-11. Epub 2006 Jan 15. PMID: 16415864

Georgescu D, Sears RM, Hommel JD, Barrot M, Bolaños CA, Marsh DJ, Bednarek MA, Bibb JA, Maratos-Flier E, Nestler EJ and DiLeone RJ: The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J Neurosci. 2005 Mar 16;25 (11) :2933-40. PMID: 15772353

Holder JL Jr, Zhang L, Kublaoui BM, DiLeone RJ, Oz OK, Bair CH, Lee YH and Zinn AR: Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Am J Physiol Endocrinol Metab. 2004 Jul;287 (1) :E105-13. Epub 2004 Feb 24. PMID: 14982752

Hommel JD, Sears RM, Georgescu D, Simmons DL and DiLeone RJ: Local gene knockdown in the brain using viral-mediated RNA interference. Nat Med. 2003 Dec;9 (12) :1539-44. Epub 2003 Nov 23. PMID: 14634645


Zachariou V, Georgescu D, Sanchez N, Rahman Z, DiLeone R, Berton O, Neve RL, Sim-Selley LJ, Selley DE, Gold SJ and Nestler EJ: Essential role for RGS9 in opiate action. Proc Natl Acad Sci U S A. 2003 Nov 11;100 (23) :13656-61. Epub 2003 Oct 31. PMID: 14595021


DiLeone RJ, Georgescu D and Nestler EJ: Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci. 2003 Jun 27;73 (6) :759-68. PMID: 12801597


Rahman Z, Schwarz J, Gold SJ, Zachariou V, Wein MN, Choi KH, Kovoor A, Chen CK, DiLeone RJ, Schwarz SC, Selley DE, Sim-Selley LJ, Barrot M, Luedtke RR, Self D, Neve RL, Lester HA, Simon MI and Nestler EJ: RGS9 modulates dopamine signaling in the basal ganglia. Neuron. 2003 Jun 19;38 (6) :941-52. PMID: 12818179


Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, Eisch AJ, Yanagisawa M, Nestler EJ and DiLeone RJ: Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci. 2003 Apr 15;23 (8) :3106-11. PMID: 12716916

Chao JR, Ni YG, Bolaños CA, Rahman Z, DiLeone RJ and Nestler EJ: Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB. Eur J Neurosci. 2002 Oct;16 (7) :1284-94. PMID: 12405989


Barrot M, Olivier JD, Perrotti LI, DiLeone RJ, Berton O, Eisch AJ, Impey S, Storm DR, Neve RL, Yin JC, Zachariou V and Nestler EJ: CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci U S A. 2002 Aug 20;99 (17) :11435-40. Epub 2002 Aug 6. PMID: 12165570


Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ and Monteggia LM: Neurobiology of depression. Neuron. 2002 Mar 28;34 (1) :13-25. PMID: 11931738

DiLeone RJ, Marcus GA, Johnson MD and Kingsley DM: Efficient studies of long-distance Bmp5 gene regulation using bacterial artificial chromosomes. Proc Natl Acad Sci U S A. 2000 Feb 15;97 (4) :1612-7. PMID: 10677507

DiLeone RJ, Russell LB and Kingsley DM: An extensive 3' regulatory region controls expression of Bmp5 in specific anatomical structures of the mouse embryo. Genetics. 1998 Jan;148 (1) :401-8. PMID: 9475750

DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA and Kingsley DM: The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4. Genomics. 1997 Feb 15;40 (1) :196-8. PMID: 9070944

King JA, Storm EE, Marker PC, Dileone RJ and Kingsley DM: The role of BMPs and GDFs in development of region-specific skeletal structures. Ann N Y Acad Sci. 1996 Jun 8;785 :70-9. PMID: 8702185