Recent Publications

Taylor SR, Badurek S, Dileone RJ, Nashmi R, Minichiello L and Picciotto MR: GABAergic and glutamatergic efferents of the mouse ventral tegmental area. J Comp Neurol. 2014 Oct 1;522 (14) :3308-34. PMID: 24715505


Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, DiLeone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS and Luquet S: Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry. 2014 Oct;19 (10) :1095-105. Epub 2014 Apr 15. PMID: 24732670


Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhännen T, Jeong JK and Diano S: Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proc Natl Acad Sci U S A. 2014 Aug 12;111 (32) :11876-81. Epub 2014 Jul 28. PMID: 25071172


van den Heuvel JK, Furman K, Gumbs MC, Eggels L, Opland DM, Land BB, Kolk SM, Narayanan N, Fliers E, Kalsbeek A, DiLeone RJ and la Fleur SE: Neuropeptide Y Activity in the Nucleus Accumbens Modulates Feeding Behavior and Neuronal Activity. Biol Psychiatry. 2014 Jun 18; Epub 2014 Jun 18. PMID: 25109664


Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK and Duman RS: REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nat Med. 2014 May;20 (5) :531-5. Epub 2014 Apr 13. PMID: 24728411


Udo T, Weinberger AH, Grilo CM, Brownell KD, DiLeone RJ, Lampert R, Matlin SL, Yanagisawa K and McKee SA: Heightened vagal activity during high-calorie food presentation in obese compared with non-obese individuals--results of a pilot study. Obes Res Clin Pract. 2014 May-Jun;8 (3) :e201-98. PMID: 24847667


Maldonado-Avilés JG and Dileone RJ: Inhaling: endocannabinoids and food intake. Nat Neurosci. 2014 Mar;17 (3) :336-7. PMID: 24569827


Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, Grimaldi DM, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK and DiLeone RJ: Medial prefrontal D1 dopamine neurons control food intake. Nat Neurosci. 2014 Feb;17 (2) :248-53. Epub 2014 Jan 19. PMID: 24441680


Arendt DH, Hassell J, Li H, Achua JK, Guarnieri DJ, Dileone RJ, Ronan PJ and Summers CH: Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala. Psychoneuroendocrinology. 2014 Feb;40 :17-26. Epub 2013 Oct 30. PMID: 24485472


Land BB, Brayton CE, Furman KE, Lapalombara Z and Dileone RJ: Optogenetic inhibition of neurons by internal light production. Front Behav Neurosci. 2014;8 :108. Epub 2014 Apr 1. PMID: 24744708


Anastasio NC, Stutz SJ, Fox RG, Sears RM, Emeson RB, DiLeone RJ, O'Neil RT, Fink LH, Li D, Green TA, Moeller FG and Cunningham KA: Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence. Neuropsychopharmacology. 2014 Jan;39 (2) :370-82. Epub 2013 Aug 13. PMID: 23939424

Gourley SL, Olevska A, Zimmermann KS, Ressler KJ, Dileone RJ and Taylor JR: The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum. Eur J Neurosci. 2013 Aug;38 (3) :2382-8. Epub 2013 May 8. PMID: 23651226


Sarhan M, Pawlowski SA, Barthas F, Yalcin I, Kaufling J, Dardente H, Zachariou V, Dileone RJ, Barrot M and Veinante P: BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia. Int J Neuropsychopharmacol. 2013 Aug;16 (7) :1649-60. Epub 2013 Feb 21. PMID: 23425507


Tellez LA, Ferreira JG, Medina S, Land BB, DiLeone RJ and de Araujo IE: Flavor-independent maintenance, extinction, and reinstatement of fat self-administration in mice. Biol Psychiatry. 2013 May 1;73 (9) :851-9. PMID: 23587200


Udo T, Grilo CM, Brownell KD, Weinberger AH, Dileone RJ and McKee SA: Modeling the effects of positive and negative mood on the ability to resist eating in obese and non-obese individuals. Eat Behav. 2013 Jan;14 (1) :40-6. Epub 2012 Oct 31. PMID: 23265400


Guarnieri DJ and DiLeone RJ: Transcriptional plasticity in the brain following metabolic challenge. Neuropsychopharmacology. 2013 Jan;38 (1) :237-8. PMID: 23147479

Narayanan NS, Land BB, Solder JE, Deisseroth K and DiLeone RJ: Prefrontal D1 dopamine signaling is required for temporal control. Proc Natl Acad Sci U S A. 2012 Dec 11;109 (50) :20726-31. Epub 2012 Nov 26. PMID: 23185016


Gourley SL, Swanson AM, Jacobs AM, Howell JL, Mo M, Dileone RJ, Koleske AJ and Taylor JR: Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding. Proc Natl Acad Sci U S A. 2012 Dec 11;109 (50) :20714-9. Epub 2012 Nov 26. PMID: 23185000


DiLeone RJ, Taylor JR and Picciotto MR: The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction. Nat Neurosci. 2012 Oct;15 (10) :1330-5. Epub 2012 Sep 25. PMID: 23007187


Kanoski SE, Zhao S, Guarnieri DJ, DiLeone RJ, Yan J, De Jonghe BC, Bence KK, Hayes MR and Grill HJ: Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. Am J Physiol Endocrinol Metab. 2012 Aug 15;303 (4) :E496-503. Epub 2012 Jun 12. PMID: 22693203


Land BB and DiLeone RJ: Losing the lust for life: a new role for an old feeding Peptide? Neuron. 2012 Aug 9;75 (3) :360-2. PMID: 22884320


D'Sa C, Dileone RJ, Anderson GM and Sinha R: Serum and plasma brain-derived neurotrophic factor (BDNF) in abstinent alcoholics and social drinkers. Alcohol. 2012 May;46 (3) :253-9. Epub 2012 Feb 22. PMID: 22364688


Guarnieri DJ, Brayton CE, Richards SM, Maldonado-Aviles J, Trinko JR, Nelson J, Taylor JR, Gourley SL and DiLeone RJ: Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction. Biol Psychiatry. 2012 Feb 15;71 (4) :358-65. PMID: 21855858

D'Sa C, Fox HC, Hong AK, Dileone RJ and Sinha R: Increased serum brain-derived neurotrophic factor is predictive of cocaine relapse outcomes: a prospective study. Biol Psychiatry. 2011 Oct 15;70 (8) :706-11. Epub 2011 Jul 8. PMID: 21741029


Gearhardt AN, Grilo CM, DiLeone RJ, Brownell KD and Potenza MN: Can food be addictive? Public health and policy implications. Addiction. 2011 Jul;106 (7) :1208-12. Epub 2011 Feb 14. PMID: 21635588


Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB and Picciotto MR: Nicotine decreases food intake through activation of POMC neurons. Science. 2011 Jun 10;332 (6035) :1330-2. PMID: 21659607


Mul JD, la Fleur SE, Toonen PW, Afrasiab-Middelman A, Binnekade R, Schetters D, Verheij MM, Sears RM, Homberg JR, Schoffelmeer AN, Adan RA, DiLeone RJ, De Vries TJ and Cuppen E: Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat. PLoS One. 2011 May 5;6 (5) :e19600. Epub 2011 May 5. PMID: 21573180


DiLeone RJ: Neuroscience gets nutrition. Nat Neurosci. 2011 Mar;14 (3) :271-2. PMID: 21346742


Trinko R, Gan G, Gao XB, Sears RM, Guarnieri DJ and DiLeone RJ: Erk1/2 mediates leptin receptor signaling in the ventral tegmental area. PLoS One. 2011;6 (11) :e27180. Epub 2011 Nov 4. PMID: 22076135


Ploski JE, Monsey MS, Nguyen T, DiLeone RJ and Schafe GE: The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories. PLoS One. 2011;6 (8) :e23760. Epub 2011 Aug 22. PMID: 21887312

Mukherjee S, Coque L, Cao JL, Kumar J, Chakravarty S, Asaithamby A, Graham A, Gordon E, Enwright JF 3rd, DiLeone RJ, Birnbaum SG, Cooper DC and McClung CA: Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior. Biol Psychiatry. 2010 Sep 15;68 (6) :503-11. Epub 2010 Jun 29. PMID: 20591414


Okamoto H, Voleti B, Banasr M, Sarhan M, Duric V, Girgenti MJ, Dileone RJ, Newton SS and Duman RS: Wnt2 expression and signaling is increased by different classes of antidepressant treatments. Biol Psychiatry. 2010 Sep 15;68 (6) :521-7. Epub 2010 Jun 8. PMID: 20570247


Sears RM, Liu RJ, Narayanan NS, Sharf R, Yeckel MF, Laubach M, Aghajanian GK and DiLeone RJ: Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone. J Neurosci. 2010 Jun 16;30 (24) :8263-73. PMID: 20554878


Sharf R, Sarhan M, Brayton CE, Guarnieri DJ, Taylor JR and DiLeone RJ: Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement. Biol Psychiatry. 2010 Apr 15;67 (8) :753-60. Epub 2010 Feb 26. PMID: 20189166


Sharf R, Guarnieri DJ, Taylor JR and DiLeone RJ: Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization. Brain Res. 2010 Mar 4;1317 :24-32. Epub 2009 Dec 23. PMID: 20034477


Sharf R, Sarhan M and Dileone RJ: Role of orexin/hypocretin in dependence and addiction. Brain Res. 2010 Feb 16;1314 :130-8. Epub 2009 Aug 20. PMID: 19699189


Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK and Grill HJ: Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab. 2010 Jan;11 (1) :77-83. PMID: 20074530


Narayanan NS, Guarnieri DJ and DiLeone RJ: Metabolic hormones, dopamine circuits, and feeding. Front Neuroendocrinol. 2010 Jan;31 (1) :104-12. Epub 2009 Oct 28. PMID: 19836414

Gourley SL, Howell JL, Rios M, DiLeone RJ and Taylor JR: Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. Learn Mem. 2009 Dec;16 (12) :756-60. Epub 2009 Nov 19. PMID: 19926781


Berton O, Guigoni C, Li Q, Bioulac BH, Aubert I, Gross CE, Dileone RJ, Nestler EJ and Bezard E: Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease. Biol Psychiatry. 2009 Sep 15;66 (6) :554-61. Epub 2009 May 28. PMID: 19481198


Winstanley CA, Green TA, Theobald DE, Renthal W, LaPlant Q, DiLeone RJ, Chakravarty S and Nestler EJ: DeltaFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine. Pharmacol Biochem Behav. 2009 Sep;93 (3) :278-84. Epub 2008 Dec 16. PMID: 19135469


DiLeone RJ: Leptin: taking the path less traveled. Cell Metab. 2009 Aug;10 (2) :77-8. PMID: 19656482


DiLeone RJ: The influence of leptin on the dopamine system and implications for ingestive behavior. Int J Obes (Lond). 2009 Jun;33 Suppl 2 :S25-9. PMID: 19528975


Graham DL, Krishnan V, Larson EB, Graham A, Edwards S, Bachtell RK, Simmons D, Gent LM, Berton O, Bolanos CA, DiLeone RJ, Parada LF, Nestler EJ and Self DW: Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol Psychiatry. 2009 Apr 15;65 (8) :696-701. Epub 2008 Nov 6. PMID: 18990365


Simen AA, DiLeone R and Arnsten AF: Primate models of schizophrenia: future possibilities. Prog Brain Res. 2009;179 :117-25. Epub 2009 Nov 20. PMID: 20302824

Wallace DL, Vialou V, Rios L, Carle-Florence TL, Chakravarty S, Kumar A, Graham DL, Green TA, Kirk A, Iñiguez SD, Perrotti LI, Barrot M, DiLeone RJ, Nestler EJ and Bolaños-Guzmán CA: The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior. J Neurosci. 2008 Oct 8;28 (41) :10272-7. PMID: 18842886


Sharf R, Sarhan M and Dileone RJ: Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell. Biol Psychiatry. 2008 Aug 1;64 (3) :175-83. Epub 2008 Apr 18. PMID: 18423425


Guarnieri DJ and DiLeone RJ: MicroRNAs: a new class of gene regulators. Ann Med. 2008;40 (3) :197-208. PMID: 18382885

Benavides DR, Quinn JJ, Zhong P, Hawasli AH, DiLeone RJ, Kansy JW, Olausson P, Yan Z, Taylor JR and Bibb JA: Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability. J Neurosci. 2007 Nov 21;27 (47) :12967-76. PMID: 18032670


Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, DiLeone RJ, Greer CA, Mandyam CD and Eisch AJ: Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci. 2007 Nov 14;27 (46) :12623-9. PMID: 18003841


Winstanley CA, LaPlant Q, Theobald DE, Green TA, Bachtell RK, Perrotti LI, DiLeone RJ, Russo SJ, Garth WJ, Self DW and Nestler EJ: DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J Neurosci. 2007 Sep 26;27 (39) :10497-507. PMID: 17898221


Trinko R, Sears RM, Guarnieri DJ and DiLeone RJ: Neural mechanisms underlying obesity and drug addiction. Physiol Behav. 2007 Aug 15;91 (5) :499-505. Epub 2007 Jan 16. PMID: 17292426


Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M and Self DW: Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat Neurosci. 2007 Aug;10 (8) :1029-37. Epub 2007 Jul 8. PMID: 17618281

de Lecea L, Jones BE, Boutrel B, Borgland SL, Nishino S, Bubser M and DiLeone R: Addiction and arousal: alternative roles of hypothalamic peptides. J Neurosci. 2006 Oct 11;26 (41) :10372-5. PMID: 17035520


Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M and DiLeone RJ: Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron. 2006 Sep 21;51 (6) :801-10. PMID: 16982424


Green TA, Alibhai IN, Hommel JD, DiLeone RJ, Kumar A, Theobald DE, Neve RL and Nestler EJ: Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. J Neurosci. 2006 Aug 9;26 (32) :8235-42. PMID: 16899718


Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW and Nestler EJ: Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006 Feb 10;311 (5762) :864-8. PMID: 16469931


Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A and Nestler EJ: An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci. 2006 Feb;9 (2) :205-11. Epub 2006 Jan 15. PMID: 16415864

Georgescu D, Sears RM, Hommel JD, Barrot M, Bolaños CA, Marsh DJ, Bednarek MA, Bibb JA, Maratos-Flier E, Nestler EJ and DiLeone RJ: The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J Neurosci. 2005 Mar 16;25 (11) :2933-40. PMID: 15772353

Holder JL Jr, Zhang L, Kublaoui BM, DiLeone RJ, Oz OK, Bair CH, Lee YH and Zinn AR: Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Am J Physiol Endocrinol Metab. 2004 Jul;287 (1) :E105-13. Epub 2004 Feb 24. PMID: 14982752

Hommel JD, Sears RM, Georgescu D, Simmons DL and DiLeone RJ: Local gene knockdown in the brain using viral-mediated RNA interference. Nat Med. 2003 Dec;9 (12) :1539-44. Epub 2003 Nov 23. PMID: 14634645


Zachariou V, Georgescu D, Sanchez N, Rahman Z, DiLeone R, Berton O, Neve RL, Sim-Selley LJ, Selley DE, Gold SJ and Nestler EJ: Essential role for RGS9 in opiate action. Proc Natl Acad Sci U S A. 2003 Nov 11;100 (23) :13656-61. Epub 2003 Oct 31. PMID: 14595021


DiLeone RJ, Georgescu D and Nestler EJ: Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci. 2003 Jun 27;73 (6) :759-68. PMID: 12801597


Rahman Z, Schwarz J, Gold SJ, Zachariou V, Wein MN, Choi KH, Kovoor A, Chen CK, DiLeone RJ, Schwarz SC, Selley DE, Sim-Selley LJ, Barrot M, Luedtke RR, Self D, Neve RL, Lester HA, Simon MI and Nestler EJ: RGS9 modulates dopamine signaling in the basal ganglia. Neuron. 2003 Jun 19;38 (6) :941-52. PMID: 12818179


Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, Eisch AJ, Yanagisawa M, Nestler EJ and DiLeone RJ: Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci. 2003 Apr 15;23 (8) :3106-11. PMID: 12716916

Chao JR, Ni YG, Bolaños CA, Rahman Z, DiLeone RJ and Nestler EJ: Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB. Eur J Neurosci. 2002 Oct;16 (7) :1284-94. PMID: 12405989


Barrot M, Olivier JD, Perrotti LI, DiLeone RJ, Berton O, Eisch AJ, Impey S, Storm DR, Neve RL, Yin JC, Zachariou V and Nestler EJ: CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci U S A. 2002 Aug 20;99 (17) :11435-40. Epub 2002 Aug 6. PMID: 12165570


Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ and Monteggia LM: Neurobiology of depression. Neuron. 2002 Mar 28;34 (1) :13-25. PMID: 11931738

DiLeone RJ, Marcus GA, Johnson MD and Kingsley DM: Efficient studies of long-distance Bmp5 gene regulation using bacterial artificial chromosomes. Proc Natl Acad Sci U S A. 2000 Feb 15;97 (4) :1612-7. PMID: 10677507

DiLeone RJ, Russell LB and Kingsley DM: An extensive 3' regulatory region controls expression of Bmp5 in specific anatomical structures of the mouse embryo. Genetics. 1998 Jan;148 (1) :401-8. PMID: 9475750

DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA and Kingsley DM: The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4. Genomics. 1997 Feb 15;40 (1) :196-8. PMID: 9070944

King JA, Storm EE, Marker PC, Dileone RJ and Kingsley DM: The role of BMPs and GDFs in development of region-specific skeletal structures. Ann N Y Acad Sci. 1996 Jun 8;785 :70-9. PMID: 8702185