Yiqiang Cai MD, PhD

Associate Research Scientist in Medicine (Nephrology)

Departments & Organizations

Internal Medicine

Research Interests

Genetic kidney diseases with focus on human polycystic kidney disease more...


  • M.D., Hunan Medical University, China, 1987
  • Ph.D., Tokushima University School of Medicine, Japan, 1995

Selected Publications

  • Publications (selected from total 44) 1) Yiqiang Cai, SV Fedeles, K Dong, et al: Altered trafficking and stability of polycystins underlie polycystic kidney disease. J Clinical Investigation, Epub 2014 Nov 3. 2) Fedeles SV, Tian X, Gallagher AR, Mitobe M, Nishio S, Lee SH, Cai Y, Geng L, Crews CM, Somlo S: A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat Genet. 2011 Jun 19;43(7):639-47. 3) Yiqiang Cai: Polycystic Kidney Disease, in “Encyclopedia of Cancer”, 2nd Edition, Edited by M. Schwab, Springer (online published, 2009). 4) Yiqiang Cai: Arachidonic acid cytochrome P450 4F2 in hypertension: what can we learn from a transgenic mouse model? (Commentary), Kidney International. 2009 Jun; 75(12):1253-4. 5) Yiqiang Cai and Stefan Somlo: Too much of a good thing: does Nek8 link polycystic kidney disease and nephronophthisis? (Commentary), J Am Soc Nephrol. 2008 19(3):418-20. 6) Cai Yiqiang, Anyatonwu G, Okuhara D, Lee KB, Yu Z, Onoe T, Mei CL, Qian Q, Geng L, Witzgall R, Ehrlich BE, Somlo S. Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812. J Biol Chem. 2004, 7;279(19):19987-95. 7) Koulen P, Cai Yiqiang, Geng L, Maeda Y, Nishimura S, Witzgall R, Ehrlich BE, Somlo S., Polycystin-2 is an intracellular calcium release channel. Nat. Cell Biol., 4(3):191-197, 2002. 8) Yiqiang Cai, Yoshiko Maeda, Anna Cedzich, Vicente E. Torres, Guanqing Wu, Tomohito Hayashi, Toshio Mochizuki, Jong Hoon Park, Ralph Witzgall, and Stefan Somlo: Identification and characterization of polycystin-2, the PKD2 gene product. J Biol Chem., 274:28557-28565, 1999.



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