YCVRC houses ~110 investigators (undergraduate and graduate students, postdoctoral trainees and faculty members) interested in basic and translational research. Major research themes include developmental and cell biology, signaling, genetics, cardiomyocyte biology and stems cells. The Center has its own zebrafish facility as well as an extensive array of core facilities.
The Center core laboratories include:
- Confocal microscopy:point scanning (Leica) and spinning disk (Perking Elmer) microscopes equipped for fixed and live cell imaging
- Mouse Genotyping and Cell Isolation Core
- Primary cell isolation and mouse genotyping (Arteriogenesis PPG core)
- Mouse physiology: in vivo and ex vivo studies of cardiac function, Langerhans hearts, blood pressure and ECG monitoring
- Microsurgery core: mouse and rat surgery
- Micro-CT core: in vitro and in vivo micro-CT imaging
- Mouse breeding core: management of mouse colonies
- Surgical and imaging Core: large animal surgery and imaging (Arteriogenesis PPG core)
- Zebrafish facility: includes zebrafish housing as well facilities for live fish imaging and microinjections
In addition, YCVRC investigators have full access to the Yale Translational Imaging Center (Y-TRIC) facilities that include a dedicated hybrid CT-SPECT scanner, 2D/3D mouse and large animal echo and other imaging resources. Studies at the Y-TRIC focus on multi-modality imaging, molecular imaging and cardiovascular device development.
YCVRC activities in FY 2013 were supported by $14.0m in funding including $11.6M in NIH, $2.2M in Foundation and $0.2M in industry funding This includes:
- Two T32 NIH training grants (Vascular Biology and Molecular Imaging)
- Five K08 and K02 grants
- One P01 PPG and one US4 Award
- European Research Community (ERC) FP6 Award
- Leducq Foundation Trans-Atlantic Network (ARTEMIS) Award
Foundation funding, in addition to the Leducq Foundation, includes grants from the American Heart Association, Howard Hughes Medical Institute, and the Connecticut Stem Cell Foundation.