Yale Cardiovascular Research Center (YCVRC)
Yale Cardiovascular Research Center (YCVRC) brings together under one room a diverse group of investigators interested in fundamental cardiovascular research and in translation of basic science discoveries to clinical practice. The guiding principles of YCVRC operations are:
- Thorough understanding of the biology of disease and its molecular mechanisms is necessary to the successful development of new therapies.
- Advances in biomedical research are best made in the environment that promotes daily interactions between clinicians, physician-scientists and basic investigators and that facilitates.
- Critical mass of individuals with diverse expertise promotes creativity and facilitates scientific discovery.
- Best science, best minds without regard for discipline or national boundaries
YCVRC faculty comes from eight different countries and four continents.
The principles areas of investigation pursued by YCVRC investigators encompass cardiovascular developmental biology, neurovascular interactions, cell signaling, genetics and stem cell biology. These are carried out using a full array of techniques utilizing mouse and zebrafish models as well as human material.The Center core facilities include a mouse physiology laboratory including state of the art micro-CT and echocardiographic imaging, confocal microscopy (including both point scanning and spinning disk microscopes) and a zebrafish facility.
YCVRC research activities are funded by a variety of services including National Institutes of Health, Howard Hughes Medical Institute, American Heart Association, Leducq Foundation, Connecticut Innovations, FAMRI, Williams Syndrome Foundation, American Society of Transplantation.
In AY’ 2012 total YCVRC funding was $22,898,568. million dollars. NIH funding included two T32 training grant in vascular biology, 5 K02/K02 grants, F32 training grant, 30 R01 grants, 3 U01 grants, 2 P01/P50 grant components, 1 P30 and 1 R21 grant and 1 PPG for a total federal funding of $16.6 million dollars. Foundations funding accounted for another $2.5 million dollars and Industry funding of $3.8 million dollars.