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Vahid Mohsenin, MD

Professor Emeritus of Medicine; Senior Fellow, The John B. Pierce Laboratory

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Research Summary

Mechanisms of endothelial dysfunction and vascular complications in hypoxia and obstructive sleep apnea

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Selected Publications

PolysomnographyJafari B, Mohsenin V. Polysomnography. 2023, 374-387. DOI: 10.1016/b978-0-12-822963-7.00174-2.
Obstructive Sleep Apnea and Polycystic Ovary SyndromeChu Y, Hilbert J, Mohsenin V. Obstructive Sleep Apnea and Polycystic Ovary Syndrome. 2022, 393-409. DOI: 10.1007/978-3-030-92589-5_20.
Pulmonary Hypertension in Obstructive Sleep ApneaMohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea. 2021, 69-76. DOI: 10.1007/978-3-030-57942-5_6.
Obstructive Sleep Apnea Increases the Risk of Pulmonary Hypertension Independent of Relevant Risk FactorsShojaee A, Mohsenin V. Obstructive Sleep Apnea Increases the Risk of Pulmonary Hypertension Independent of Relevant Risk Factors. 2020, a6252-a6252. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6252.
Treating Sleep-Related Breathing DisordersWon C, Mohsenin V, Kryger M. Treating Sleep-Related Breathing Disorders. 2018, 105-123. DOI: 10.1007/978-1-4939-8607-1_9.
0591 PHYSICAL EXAM FINDINGS AS PREDICTORS OF CLINICAL OUTCOMES IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA TREATED WITH MANDIBULAR ADVANCEMENT DEVICEWojeck B, Al-Halawani M, Etemad L, Radmand R, Mohsenin V. 0591 PHYSICAL EXAM FINDINGS AS PREDICTORS OF CLINICAL OUTCOMES IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA TREATED WITH MANDIBULAR ADVANCEMENT DEVICE. Sleep 2017, 40: a219-a219. DOI: 10.1093/sleepj/zsx050.590.
Chapter 122 Sleep and Breathing at High AltitudeMohsenin V, Javaheri S, Dempsey J. Chapter 122 Sleep and Breathing at High Altitude. 2017, 1211-1221.e4. DOI: 10.1016/b978-0-323-24288-2.00122-7.
Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apneaJafari B, Mohsenin V. Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea. Sleep Medicine 2016, 25: 87-92. PMID: 27823723, DOI: 10.1016/j.sleep.2016.08.001.
The emerging role of microRNAs in hypoxia-induced pulmonary hypertensionMohsenin V. The emerging role of microRNAs in hypoxia-induced pulmonary hypertension. Sleep And Breathing 2016, 20: 1059-1067. PMID: 27154628, DOI: 10.1007/s11325-016-1351-y.
Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependenceMorgan PT, Angarita GA, Canavan S, Pittman B, Oberleitner L, Malison RT, Mohsenin V, Hodges S, Easton C, McKee S, Bessette A, Forselius E. Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence. Drug And Alcohol Dependence 2016, 160: 49-56. PMID: 26777774, PMCID: PMC4767553, DOI: 10.1016/j.drugalcdep.2015.12.004.
Feasibility and Efficacy of a Self-Management Intervention for Insomnia in Stable Heart Failure.Redeker NS, Jeon S, Andrews L, Cline J, Jacoby D, Mohsenin V. Feasibility and Efficacy of a Self-Management Intervention for Insomnia in Stable Heart Failure. Journal Of Clinical Sleep Medicine 2015, 11: 1109-19. PMID: 25979100, PMCID: PMC4582052, DOI: 10.5664/jcsm.5082.
Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and PathophysiologyKholdani C, Fares WH, Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea: Is it Clinically Significant? a Critical Analysis of the Association and Pathophysiology. Pulmonary Circulation 2015, 5: 220-227. PMID: 26064448, PMCID: PMC4449234, DOI: 10.1086/679995.
Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the BlockMohsenin V. Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block. The American Journal Of Medicine 2015, 128: 811-816. PMID: 25731137, DOI: 10.1016/j.amjmed.2015.01.037.
Assessment of preload and fluid responsiveness in intensive care unit. How good are we?Mohsenin V. Assessment of preload and fluid responsiveness in intensive care unit. How good are we? Journal Of Critical Care 2015, 30: 567-573. PMID: 25682347, DOI: 10.1016/j.jcrc.2015.01.004.
Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep ApneaJafari B, Elias JA, Mohsenin V. Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea. PLOS ONE 2014, 9: e98629. PMID: 24878721, PMCID: PMC4039537, DOI: 10.1371/journal.pone.0098629.
Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia?Mohsenin V, Jafari B. Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia? Sleep Medicine 2013, 14: e210. DOI: 10.1016/j.sleep.2013.11.503.
Assessment and management of cerebral edema and intracranial hypertension in acute liver failureMohsenin V. Assessment and management of cerebral edema and intracranial hypertension in acute liver failure. Journal Of Critical Care 2013, 28: 783-791. PMID: 23683564, DOI: 10.1016/j.jcrc.2013.04.002.
Narcolepsy-Characteristics of those in the Borderland-We Need a Better Diagnostic ToolMahmoudi M, Won C, Mohsenin V. Narcolepsy-Characteristics of those in the Borderland-We Need a Better Diagnostic Tool. Journal Of Sleep Disorders Treatment & Care 2013, 02 DOI: 10.4172/2325-9639.1000106.
PolysomnographyJafari B, Mohsenin V. Polysomnography. 2013, 465-474. DOI: 10.1016/b978-0-12-378610-4.00352-1.
Rehabilitation of stroke and sleep apneaJafari B, Mohsenin V. Rehabilitation of stroke and sleep apnea. 2012, 127-138. DOI: 10.1017/cbo9781139061056.013.
Fluid Shift in Obstructive Sleep Apnea: ResponseMohsenin V, Jafari B. Fluid Shift in Obstructive Sleep Apnea: Response. CHEST Journal 2012, 141: 830. DOI: 10.1378/chest.11-3237.
Role Of Nitric Oxide-Dependent Vasodilatation And Carbon Monoxide In Developing Hypertension In Obstructive Sleep Apnea (OSA)Jafari B, Mohsenin V. Role Of Nitric Oxide-Dependent Vasodilatation And Carbon Monoxide In Developing Hypertension In Obstructive Sleep Apnea (OSA). 2011, a2218-a2218. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2218.
PrefaceYaggi H, Chiong T, Mohsenin V. Preface. Clinics In Chest Medicine 2010, 31: xiii-xiv. DOI: 10.1016/j.ccm.2010.03.003.
Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic AttackBravata DM, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Knight HJ, Lo A, Richerson GB, Gorman M, Williams LS, Brass LM, Agostini J, Mohsenin V, Roux F, Yaggi HK. Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic Attack. Stroke 2010, 41: 1464-1470. PMID: 20508184, PMCID: PMC4567557, DOI: 10.1161/strokeaha.109.566745.
The Diagnosis and Treatment of Sleep Apnea among Patients with Acute Ischemic Stroke: Results of a Feasiblity Study.Yaggi H, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Lo A, Richerson G, Gorman M, Williams L, Brass L, Agostini J, Mohsenin V, Roux F, Bravata D. The Diagnosis and Treatment of Sleep Apnea among Patients with Acute Ischemic Stroke: Results of a Feasiblity Study. 2009, a5338. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5338.
The Diagnosis and Treatment of Sleep Apnea among Patients with Transient Ischemic Attack: Results of a Feasibility Study.Yaggi H, Concato J, Mohsenin V, McClain V, Fried T, Ranjbar N, Sadarangani T, Struve F, Zygmunt L, Lo A, Richerson G, Gorman M, Williams L, Brass L, Agostini J, Roux F, Bravata D. The Diagnosis and Treatment of Sleep Apnea among Patients with Transient Ischemic Attack: Results of a Feasibility Study. 2009, a3989. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3989.
Sleep Physiology in PregnancyBourjeily G, Mohsenin V. Sleep Physiology in Pregnancy. 2009, 37-55. DOI: 10.1007/978-1-59745-445-2_4.
Sleep Apnea and Stroke: A Risk Factor or an Association?Yaggi H, Mohsenin V. Sleep Apnea and Stroke: A Risk Factor or an Association? Sleep Medicine Clinics 2007, 2: 583-591. DOI: 10.1016/j.jsmc.2007.07.004.
Sleep in Chronic Obstructive Pulmonary DiseaseMohsenin V. Sleep in Chronic Obstructive Pulmonary Disease. Sleep Medicine Clinics 2007, 2: 1-8. DOI: 10.1016/j.jsmc.2006.11.013.
Contributing AuthorsTechnologists I, Atkinson J, Avidan A, Bae C, Barkoukis T, Bassetti C, Bazil C, Bhadriraju S, Chen W, Chong D, Cohen D, D'Ambrosio C, Dimitriu V, Dumitru I, El-Ad B, Foldvary-Schaefer N, Foresman B, Gabel T, Giglio P, Hammond R, Hanak V, Holtby S, Katz E, Keenan S, Kotagal S, Krahn L, Lane J, Lee-Chiong T, Loots M, Matheson J, Mignot E, Mohsenin V, Polnitsky C, Sahlem G, Schweitzer P, Siccoli M, Sinton C, Smith R, Somers V, Wiebelhaus J, Zallek S, Zee P. Contributing Authors. 2007, vii-ix. DOI: 10.1016/b978-075067563-5.10031-8.
ELECTRIC AND MAGNETIC FIELDSYaggi H, Mohsenin V. ELECTRIC AND MAGNETIC FIELDS. 2006, 88-91. DOI: 10.1201/b14948-16.
Chronic obstructive pulmonary disease and sleep: the interaction.Urbano F, Mohsenin V. Chronic obstructive pulmonary disease and sleep: the interaction. Panminerva Medica 2006, 48: 223-30. PMID: 17215794.
Sleep Apnea and Cerebrovascular DiseaseMohsenin V, Yaggi H. Sleep Apnea and Cerebrovascular Disease. 2005, 287-292. DOI: 10.1002/0471751723.ch38.
Is sleep apnea a risk factor for stroke? A critical analysis.Mohsenin V. Is sleep apnea a risk factor for stroke? A critical analysis. Minerva Medica 2004, 95: 291-305. PMID: 15334043.
Gender Differences in the Expression of Sleep-Disordered Breathing Role of Upper Airway DimensionsMohsenin V. Gender Differences in the Expression of Sleep-Disordered Breathing Role of Upper Airway Dimensions. CHEST Journal 2001, 120: 1442-1447. PMID: 11713117, DOI: 10.1378/chest.120.5.1442.
Sleep-Related Breathing Disorders and Risk of StrokeMohsenin V. Sleep-Related Breathing Disorders and Risk of Stroke. Stroke 2001, 32: 1271-1278. PMID: 11387486, DOI: 10.1161/01.str.32.6.1271.
Sleep-Related Breathing Disorders: Current Treatment OptionsMohsenin V. Sleep-Related Breathing Disorders: Current Treatment Options. Clinical Pulmonary Medicine 2001, 8: 95-100. DOI: 10.1097/00045413-200103000-00006.
Sleep-related breathing disorders and cardiovascular diseaseRoux F, D’Ambrosio C, Mohsenin V. Sleep-related breathing disorders and cardiovascular disease. The American Journal Of Medicine 2000, 108: 396-402. PMID: 10759096, DOI: 10.1016/s0002-9343(00)00302-8.
Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humansDuBois A, Kelley P, Douglas J, Mohsenin V. Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humans. Journal Of Applied Physiology 1999, 86: 159-167. PMID: 9887126, DOI: 10.1152/jappl.1999.86.1.159.
Quality of Life in Patients with Obstructive Sleep Apnea Effect of Nasal Continuous Positive Airway Pressure—A Prospective StudyD’Ambrosio C, Bowman T, Mohsenin V. Quality of Life in Patients with Obstructive Sleep Apnea Effect of Nasal Continuous Positive Airway Pressure—A Prospective Study. CHEST Journal 1999, 115: 123-129. PMID: 9925072, DOI: 10.1378/chest.115.1.123.
Production and absorption of nitric oxide gas in the noseDubois A, Douglas J, Stitt J, Mohsenin V. Production and absorption of nitric oxide gas in the nose. Journal Of Applied Physiology 1998, 84: 1217-1224. PMID: 9516187, DOI: 10.1152/jappl.1998.84.4.1217.
SLEEP IN ASTHMAD'Ambrosio C, Mohsenin V. SLEEP IN ASTHMA. Clinics In Chest Medicine 1998, 19: 127-137. PMID: 9554223, DOI: 10.1016/s0272-5231(05)70437-8.
Adaptation of Lung Antioxidants to Cigarette Smoking in HumansHilbert J, Mohsenin V. Adaptation of Lung Antioxidants to Cigarette Smoking in Humans. CHEST Journal 1996, 110: 916-920. PMID: 8874245, DOI: 10.1378/chest.110.4.916.
Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophilsOrtmeyer J, Mohsenin V. Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils. Life Sciences 1996, 59: 255-262. PMID: 8699936, DOI: 10.1016/0024-3205(96)00284-6.
Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic ResponseCain W, Leaderer B, Ginsberg G, Andrews L, Cometto-muñiz J, Gent J, Buck M, Berglund L, Mohsenin V, Monahan E, Kjaergaard S. Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic Response. Inhalation Toxicology 1996, 8: 21-48. DOI: 10.3109/08958379609005425.
Effect of nitrous acid on lung function in asthmatics: a chamber study.Beckett W, Russi M, Haber A, Rivkin R, Sullivan J, Tameroglu Z, Mohsenin V, Leaderer B. Effect of nitrous acid on lung function in asthmatics: a chamber study. Environmental Health Perspectives 1995, 103: 372-375. PMID: 7607138, PMCID: PMC1519093, DOI: 10.1289/ehp.95103372.
Sleep apnea in patients with hemispheric strokeMohsenin V, Valor R. Sleep apnea in patients with hemispheric stroke. Archives Of Physical Medicine And Rehabilitation 1995, 76: 71-76. PMID: 7811179, DOI: 10.1016/s0003-9993(95)80046-8.
Human exposure to oxides of nitrogen at ambient and supra-ambient concentrationsMohsenin V. Human exposure to oxides of nitrogen at ambient and supra-ambient concentrations. Toxicology 1994, 89: 301-312. PMID: 8023333, DOI: 10.1016/0300-483x(94)90102-3.
Surfactant Lipid Peroxidation and Inactivation of Protease Inhibitor in the Lung during Oxidant ExposureMohsenin V. Surfactant Lipid Peroxidation and Inactivation of Protease Inhibitor in the Lung during Oxidant Exposure. 1994, 27: 251-260. DOI: 10.1159/000423046.
Daytime oxygen saturation does not predict nocturnal oxygen desaturation in patients with chronic obstructive pulmonary diseaseMohsenin V, Guffanti E, Hilbert J, Ferranti R. Daytime oxygen saturation does not predict nocturnal oxygen desaturation in patients with chronic obstructive pulmonary disease. Archives Of Physical Medicine And Rehabilitation 1994, 75: 285-289. PMID: 8129580, DOI: 10.1016/0003-9993(94)90030-2.
Inhibition of protein kinase C of human neutrophils by phosphatidylcholinesYoshida K, Mohsenin V. Inhibition of protein kinase C of human neutrophils by phosphatidylcholines. Life Sciences 1994, 54: 515-524. PMID: 8107528, DOI: 10.1016/0024-3205(94)90001-9.
Glucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activationOrtmeyer J, Mohsenin V. Glucose suppresses superoxide generation in normal neutrophils: interference in phospholipase D activation. American Journal Of Physiology 1993, 264: c402-c410. PMID: 8383432, DOI: 10.1152/ajpcell.1993.264.2.c402.
Penicillium decumbens A New Cause of Fungus BallYoshida K, Hiraoka T, Ando M, Uchida K, Mohsenin V. Penicillium decumbens A New Cause of Fungus Ball. CHEST Journal 1992, 101: 1152-1153. PMID: 1555438, DOI: 10.1378/chest.101.4.1152.
Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defensesMohsenin V. Lipid peroxidation and antielastase activity in the lung under oxidant stress: role of antioxidant defenses. Journal Of Applied Physiology 1991, 70: 1456-1462. PMID: 2055821, DOI: 10.1152/jappl.1991.70.4.1456.
Unsaturated phosphatidylcholines inhibit superoxide production in human neutrophilsYoshida K, Mohsenin V. Unsaturated phosphatidylcholines inhibit superoxide production in human neutrophils. Life Sciences 1991, 49: 1359-1365. PMID: 1656156, DOI: 10.1016/0024-3205(91)90200-u.
Respiratory burst in alveolar macrophages of diabetic ratsMohsenin V, Latifpour J. Respiratory burst in alveolar macrophages of diabetic rats. Journal Of Applied Physiology 1990, 68: 2384-2390. PMID: 2166735, DOI: 10.1152/jappl.1990.68.6.2384.
Nutrition for the respiratory insufficient patient.Mohsenin V, Ferranti R, Loke J. Nutrition for the respiratory insufficient patient. The European Respiratory Journal. Supplement 1989, 7: 663s-665s. PMID: 2508653.
Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation productsMohsenin V, Gee J. Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products. Journal Of Applied Physiology 1989, 66: 2211-2215. PMID: 2787317, DOI: 10.1152/jappl.1989.66.5.2211.
Bilateral diaphragmatic paralysis: clinical spectrum, prognosis, and diagnostic approach.Chan C, Loke J, Virgulto J, Mohsenin V, Ferranti R, Lammertse T. Bilateral diaphragmatic paralysis: clinical spectrum, prognosis, and diagnostic approach. Archives Of Physical Medicine And Rehabilitation 1988, 69: 976-9. PMID: 3190422.
Airway responsiveness and prostaglandin generation in scorbutic guinea pigs.Mohsenin V, Tremml P, Rothberg K, Souhrada M, Douglas J. Airway responsiveness and prostaglandin generation in scorbutic guinea pigs. Prostaglandins Leukotrienes And Essential Fatty Acids 1988, 33: 149-55. PMID: 3186781.
Airway Responses to 2.0 ppm Nitrogen Dioxide in Normal SubjectsMohsenin V. Airway Responses to 2.0 ppm Nitrogen Dioxide in Normal Subjects. Archives Of Environmental & Occupational Health 1988, 43: 242-246. PMID: 3289507, DOI: 10.1080/00039896.1988.9934941.
Effect of Vitamin C on NO2-induced Airway Hyperresponsiveness in Normal Subjects: A Randomized Double-Blind ExperimentMohsenin V. Effect of Vitamin C on NO2-induced Airway Hyperresponsiveness in Normal Subjects: A Randomized Double-Blind Experiment. American Journal Of Respiratory And Critical Care Medicine 1987, 136: 1408-1411. PMID: 3318598, DOI: 10.1164/ajrccm/136.6.1408.
Airway responses to nitrogen dioxide in asthmatic subjectsMohsenin V. Airway responses to nitrogen dioxide in asthmatic subjects. Journal Of Toxicology And Environmental Health 1987, 22: 371-380. PMID: 3320381, DOI: 10.1080/15287398709531080.
Acute Effect of Nitrogen Dioxide Exposure on the Functional Activity of Alpha-1-Protease Inhibitor in Bronchoalveolar Lavage Fluid of Normal SubjectsMohsenin V, Gee J. Acute Effect of Nitrogen Dioxide Exposure on the Functional Activity of Alpha-1-Protease Inhibitor in Bronchoalveolar Lavage Fluid of Normal Subjects. American Journal Of Respiratory And Critical Care Medicine 1987, 136: 646-650. PMID: 3498415, DOI: 10.1164/ajrccm/136.3.646.
Vitamin C and AirwaysMOHSENIN V, DuBOIS A. Vitamin C and Airways. Annals Of The New York Academy Of Sciences 1987, 498: 259-268. PMID: 3304063, DOI: 10.1111/j.1749-6632.1987.tb23766.x.
Diaphragmatic Dysfunction in Siblings with Hereditary Motor and Sensory Neuropathy (Charcot-Marie-Tooth Disease)Chan C, Mohsenin V, Loke J, Virgulto J, Sipski M, Ferranti R. Diaphragmatic Dysfunction in Siblings with Hereditary Motor and Sensory Neuropathy (Charcot-Marie-Tooth Disease). CHEST Journal 1987, 91: 567-570. PMID: 3829750, DOI: 10.1378/chest.91.4.567.
Effect of Ascorbic Acid on Response to Methacholine Challenge in Asthmatic Subjects1–3Mohsenin V, Dubois A, Douglas J. Effect of Ascorbic Acid on Response to Methacholine Challenge in Asthmatic Subjects1–3. American Journal Of Respiratory And Critical Care Medicine 1983, 127: 143-7. PMID: 6830027, DOI: 10.1164/arrd.1983.127.2.143.

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Vahid Mohsenin, MD

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