CORE Projects

Ongoing and completed projects at CORE include:

Quality Measurement

Our Quality Measurement Group's ongoing work with the Centers for Medicare & Medicaid Services (CMS) includes new measure development, research on hospital quality including evaluation of trends, disparities and geographic variation and communications with stakeholders about hospital quality, and potential expansion of outcomes measures to other health care settings.

CCOR

In 2010, the National Heart, Lung, and Blood Institute of the National Institutes of Health established a Center for Cardiovascular Outcomes Research at Yale University, one of three identified after a national competition. CCOR’s 4-year grant will provide the research infrastructure to develop a national surveillance program for cardiovascular care and outcomes.

Hospitalomics

Hospitalomics, funded by a 4-year Donaghue Foundation grant, is a multi-disciplinary data-driven approach that combines systems thinking, outcomes sciences, and information sciences to generate information on variation in hospital care and to identify those patterns of care that are strongly associated with the best performance as measured by clinical outcomes (mortality and readmission rates) and hospital costs.

YODA Project

Each day, patients and their physicians make treatment decisions with access to only a fraction of the relevant clinical research data. Many clinical studies, including randomized clinical trials, are never published in the biomedical literature. The Yale University Open Data Access project has developed a model to facilitate access to patient-level clinical research data to promote wider availability of clinical trial data and independent analysis by external investigators.

FDA Surveillance Project

The surveillance of medical devices is intended to provide critical information to all relevant stakeholders about device safety, long-term product performance, and effectiveness in improving patient outcomes. However, we are far from this ideal system. Yale University, in partnership with Medtronic, Inc., has been selected to receive a five-year cooperative agreement from the U.S. Food and Drug Administration (FDA) that will develop methods and facilitate best practices for medical device surveillance.

Tele-HF

Tele-HF is the largest randomized controlled trial to study the effectiveness of telemonitoring on heart failure outcomes.

VIRGO

Women 55 years and younger have about twice the risk of death from a heart attack than similarly aged men. Our VIRGO group has been funded by the National Institutes of Health to examine predictors of a broad range of early and 1-year outcomes for young women with heart attacks and to examine such questions as: Do women get the same quality of care as men?

Global Health

The objective of the Global Health initiative is to strengthen the health care systems for cardiovascular disease around the world, with a current focus on China.

ACC Analytic Center

Since 2007, Yale CORE has served as an analytic center for the ICD Registry^TM and the CathPCI Registry^® of the American College of Cardiology Foundation’s National Cardiovascular Data Registry (NCDR^®). The goal of this work is to generate new knowledge and insights into the care of patients with cardiovascular disease through analysis of the robust data submitted to the NCDR^® registries. A team of CORE researchers work closely with NCDR^® staff to provide logistical and analytical support for research proposals related to its ICD Registry^® and CathPCI Registry^TM.

Survival after Acute Myocardial Infarction (SAMI)

The SAMI study defined how hospital organizational strategies may improve outcomes in patients following acute myocardial infarction.