Ongoing and completed projects at CORE include:
Massive data collections derived from millions of daily interactions within the health care system are increasingly available, but we urgently need more advanced tools to support research that can produce better personalized predictions about prognosis and response to treatments; a deeper understanding of the complex factors and their interactions that influence health at the level of the patient, the health system, and society; and more effective methods of causal inference, mitigating bias and error. We also need to find new ways to think about data, while promoting its value for individuals and organizations in the service of promoting better decisions and outcomes. Accordingly, we have assembled a remarkable team of world-class experts with complementary skills who are dedicated to deep collaboration in order to produce high impact methods and tools, primed for widespread use, that will unleash the information potential of data produced as part of routine health care delivery.
Our Quality Measurement Group's ongoing work with the Centers for Medicare & Medicaid Services (CMS) includes new measure development, research on hospital quality including evaluation of trends, disparities and geographic variation and communications with stakeholders about hospital quality, and potential expansion of outcomes measures to other health care settings.
In 2010, the National Heart, Lung, and Blood Institute of the National Institutes of Health established a Center for Cardiovascular Outcomes Research at Yale University, one of three identified after a national competition. CCOR’s 4-year grant will provide the research infrastructure to develop a national surveillance program for cardiovascular care and outcomes.
Hospitalomics, funded by a 4-year Donaghue Foundation grant, is a multi-disciplinary data-driven approach that combines systems thinking, outcomes sciences, and information sciences to generate information on variation in hospital care and to identify those patterns of care that are strongly associated with the best performance as measured by clinical outcomes (mortality and readmission rates) and hospital costs.
Each day, patients and their physicians make treatment decisions with access to only a fraction of the relevant clinical research data. Many clinical studies, including randomized clinical trials, are never published in the biomedical literature. The Yale University Open Data Access project has developed a model to facilitate access to patient-level clinical research data to promote wider availability of clinical trial data and independent analysis by external investigators.
Women 55 years and younger have about twice the risk of death from a heart attack than similarly aged men. Our VIRGO group has been funded by the National Institutes of Health to examine predictors of a broad range of early and 1-year outcomes for young women with heart attacks and to examine such questions as: Do women get the same quality of care as men?