Departments & Organizations
Neuroscience Microarray Center, Yale
Psychiatry: Connecticut Mental Health Center | Molecular Psychiatry, Division of | Stress & Addiction Clinical Research Program | VA National Center for PTSD | VA-Yale Clinical Neurosciences PTSD Research Program
Yale Combined Program in the Biological and Biomedical Sciences (BBS): Neurobiology, Neural Networks and Neuropharmacology | Neuroscience: Behavioral and Systems; Cognitive/Learning and Memory; Drug Abuse; Molecular/Cellular Neuroscience; Neural Disorders; Neuropharmacology
Dr. Duman received his doctorate degree from the University
of Texas in Houston and conducted postgraduate work at Yale University before
joining the faculty there. He has written and/or co-authored over 250 original
papers, reviews and book chapters, and has presented over 150 invited lectures.
Dr. Duman is also on the editorial board of several prestigious journals and
serves as a consultant for a number of biotech and pharmaceutical companies.
Dr. Duman’s work has focused on the molecular and cellular actions of antidepressants and stress, providing the basis for a neurotrophic hypothesis of depression. This hypothesis is based on work demonstrating that chronic antidepressant treatment increases the expression of neurotrophic factors, and increases the proliferation of new neurons and glia in the adult brain. These effects counteract the atrophy and cell loss that is caused by stress and that is thought to underlie, in part, the pathophysiology of depression. These findings represent groundbreaking advances in our understanding of antidepressants and provide a framework for developing novel therapeutic agents.
Education & Training
|PhD||University of Texas (1984)|
|Postdoctoral Fellow||Yale University School of Medicine|
|Postdoctoral Fellow||University of Texas, Houston|
Honors & Recognition
Congress of International Neuropsychopharmacology Research AwardCINP (2006)
Dr. Paul Janssen Prize for PsychopharmacologyJanssen Pharmaceutical Company (2003)
NARSAD-Nola Maddox Falcone Prize NARSAD (2002)
Anna-Monika Award for outstanding research in depressionAnna-Monika Foundation (2001)
Molecular Mechanisms of Stress & Antidepressants Japan (2008)
Ronald Duman is collaborating with a number of Japanese researchers to study the molecular and cellular mechanisms underlying the actions of stress and antidepressants.
Neurotrophic Factors and Antidepressants India (2008)
Professor Duman collaborates with a former student on the emphasis on the influence of early postnatal stress and the long-term effects of such stress on the adult animal. This focuses on interests in antidepressants and identifying mechanisms for developing better therapeutic agents. One of the...