Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsSinan Guloksuz, MD, PhD
Associate Professor Adjunct in PsychiatryAbout
Research
Publications
2025
Longitudinal Prediction of Mental Health Outcomes in Vulnerable Youth using Machine Learning
Pujadas E, Díaz-Caneja C, Stevanovic D, Quintero M, Martín-Isla C, Hernández-González J, Atehortúa A, Lazrak N, Pries L, Delespaul P, Camacho M, Gülöksüz S, Rutten B, Lekadir K. Longitudinal Prediction of Mental Health Outcomes in Vulnerable Youth using Machine Learning. Cognitive Computation 2025, 17: 152. DOI: 10.1007/s12559-025-10509-y.Peer-Reviewed Original ResearchMental health outcomesMental health statusMental distressHealth outcomesHealth statusPredictive of mental health outcomesUK Millennium Cohort StudyMillennium Cohort StudyGeneral mental distressMental illnessEmotional distressModifiable factorsLongitudinal predictionPrevention strategiesVulnerable populationsCohort studyVulnerable young peopleDistressEarly interventionHigh riskBalanced random forest modelVulnerable youthYoung peopleSleep patternsSchool environmentAssociation between the exposome score for schizophrenia and functioning in remitted first-episode psychosis: results from the HAMLETT study
Kamphuis S, Arias-Magnasco A, Gangadin S, Begemann M, Wijnen B, Veling W, de Haan L, Consortium H, Sommer I, van Os J, Bakker P, Gülöksüz S. Association between the exposome score for schizophrenia and functioning in remitted first-episode psychosis: results from the HAMLETT study. Schizophrenia Research 2025, 285: 223-231. PMID: 41056900, DOI: 10.1016/j.schres.2025.09.023.Peer-Reviewed Original ResearchConceptsES-SCZFEP patientsGAF scoresExposome scoreEpisode of psychosisFirst-episode psychosisGlobal assessmentAntipsychotic typeCannabis useSymptomatic remissionAdverse domainsWinter birthEnvironmental risk factorsGAFFunctional impairmentSchizophreniaPsychosisFEPHearing impairmentLiability scoreLinear regression modelsMultiple linear regression modelImpairmentRisk factorsMigrant statusT19. CAUSAL EFFECTS OF CANNABIS USE ON DEPRESSION AND PSYCHOSIS: INTEGRATING GENETIC AND LONGITUDINAL METHODS
Pasman J, Tunez A, Zonneveld T, Wesseldijk L, Marsden S, Abellaoui A, Have M, Luik A, Rutten B, Gülöksüz S, van Os J, Lind P, Martin N, Treur J, Verweij K. T19. CAUSAL EFFECTS OF CANNABIS USE ON DEPRESSION AND PSYCHOSIS: INTEGRATING GENETIC AND LONGITUDINAL METHODS. European Neuropsychopharmacology 2025, 99: 167. DOI: 10.1016/j.euroneuro.2025.08.302.Peer-Reviewed Original ResearchCannabis useOne-sample MRGenetic instrumentsTobacco smokeRandom intercept cross-lagged panel modelGenomic SEMEffects of cannabis useCross-lagged panel modelFamilial confoundingEffect of familial confoundingCannabis use initiationTwo-sample MR analysisCo-twin control analysesInternational Cannabis ConsortiumPsychotic outcomesRI-CLPMCannabis usersCannabis initiationPsychiatric outcomesPublic health issueStructural equation modelingSymptom trajectoriesMultivariable MRCannabisMR analysisImpact of puberty timing, status and oestradiol on psychotic experiences in the context of exposomic and genomic vulnerability to schizophrenia in female adolescents: longitudinal ABCD study.
Pries L, Prachason T, Arias-Magnasco A, Lin B, Rutten B, Guloksuz S. Impact of puberty timing, status and oestradiol on psychotic experiences in the context of exposomic and genomic vulnerability to schizophrenia in female adolescents: longitudinal ABCD study. The British Journal Of Psychiatry 2025, 1-8. PMID: 40899184, DOI: 10.1192/bjp.2025.36.Peer-Reviewed Original ResearchPsychotic experiencesPRS-SCZES-SCZAssociated with greater likelihoodAdolescent Brain Cognitive Development StudyAssociation of psychotic experiencesDevelopment of psychosisCognitive Development StudyFemale adolescentsPuberty statusNo significant interactionGreater likelihoodPubertal Development ScaleMental health outcomesAnnual follow-up assessmentsFollow-up assessmentAbsence of interactive effectsPsychosis scalesPolygenic risk scoresABCD studySchizophreniaOestradiol concentrationsFemale participantsDevelopment ScalePsychosisMental healthcare expenditure among adults by type of mental healthcare and its association with age and sex in the Netherlands between 2015 and 2020
Dijkstra L, Gülöksüz S, Batalla A, van Os J. Mental healthcare expenditure among adults by type of mental healthcare and its association with age and sex in the Netherlands between 2015 and 2020. PLOS ONE 2025, 20: e0330365. PMID: 40853948, PMCID: PMC12377576, DOI: 10.1371/journal.pone.0330365.Peer-Reviewed Original ResearchConceptsSpecialized mental healthcareMental healthcare expenditureMental healthcare costsMental healthcareHealthcare expendituresHealthcare costsMental health careType of careAge groupsYounger age groupsHealth careAssociated with ageOlder adultsYoung menHealth insuranceCohort studyHealthcareInteraction of ageCareYoung womenWomenLinear regressionSexAgeMenExamining psychological protective mechanisms as moderators of the association between autistic traits and psychosis expression in a general population twin sample
Karaçam Doğan M, Fusar-Poli L, Arias-Magnasco A, Pries L, Lin B, Klingenberg B, Bortoletto R, Colizzi M, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, van Os J, Rutten B, Luykx J, Prachason T, Guloksuz S. Examining psychological protective mechanisms as moderators of the association between autistic traits and psychosis expression in a general population twin sample. Schizophrenia Research 2025, 284: 133-140. PMID: 40774025, DOI: 10.1016/j.schres.2025.08.003.Peer-Reviewed Original ResearchCommunity Assessment of Psychic ExperiencesPsychosis expressionAutistic traitsOptimal parentingCommunity assessmentCoping stylesMultilevel linear regression modelsPsychosis vulnerabilityRisk factorsGeneral population twin samplePsychological protective factorsRisk of psychosisAutism Spectrum QuotientTotal frequency scoreReassuring thoughtsPsychological protective mechanismsSocial supportLinear regression modelsPrevention strategiesEngagement copingTwin samplePsychic ExperiencesCopingFrequency scoreExtraversionEvaluation of potential biomarker miRNAs and the levels of serotonin and dopamine in female patients with obsessive–compulsive disorder
Korkmaz N, Elibol B, Durmus Z, Ozdemir A, Akbas F, Guloksuz S, Sahbaz C. Evaluation of potential biomarker miRNAs and the levels of serotonin and dopamine in female patients with obsessive–compulsive disorder. Neuroscience 2025, 581: 50-57. PMID: 40614924, DOI: 10.1016/j.neuroscience.2025.07.001.Peer-Reviewed Original ResearchConceptsMiR-125b-5pObsessive-compulsive disorderObsessive-compulsive disorder patientsMiR-132Expression level of miR-132Dopamine levelsMiR-125b-5p expressionMiR-21-3pLevel of miR-132Pathogenesis of obsessive-compulsive disorderObsessive-compulsive disorder groupPlasma serotoninMiR-21Levels of serotoninBiomarker miRNAsPersistent obsessionsPsychiatric disordersSerotonin levelsExpression levelsSerotoninDopamineNo significant differenceFemale patientsReal-time PCRMiRNAsMapping the Exposome of Mental Health Outcomes to Enhance Population Salutogenesis
Doğan M, Guloksuz S. Mapping the Exposome of Mental Health Outcomes to Enhance Population Salutogenesis. ALPHA PSYCHIATRY 2025, 26: 44314. PMID: 40630888, PMCID: PMC12231412, DOI: 10.31083/ap44314.Peer-Reviewed Original ResearchClinical predictors of readmission to psychiatric inpatient care: A 20-year follow up study of former adolescent inpatients
Leppanen J, Kieseppä V, Eskelinen S, Säynäjäkangas V, Rutten B, Gülöksüz S, Halt A, Riipinen P, Díaz-Caneja C, Kelleher I. Clinical predictors of readmission to psychiatric inpatient care: A 20-year follow up study of former adolescent inpatients. Psychiatry Research 2025, 351: 116606. PMID: 40578224, DOI: 10.1016/j.psychres.2025.116606.Peer-Reviewed Original ResearchConceptsPsychosis symptomsTransdiagnostic markerPsychiatric inpatientsSeverity of psychosis symptomsSeverity of depressive symptomsAdolescent psychiatric inpatientsSchizophrenia spectrum diagnosisObsessive-compulsive disorderSeverity of depressionPsychiatric inpatient careMarkers of illness severityDuration of readmissionsAdolescent inpatientsSpectrum diagnosisConduct disorderPsychiatric diagnosisDepressive symptomsEating DisordersPsychosisSubstance useInpatient admissionsIllness severityClinical predictorsCumulative durationInpatientsExploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights
Wu X, Parekh P, Lin B, Pries L, Guloksuz S, Rutten B, Andreassen O, Linden D, van der Meer D. Exploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights. Schizophrenia Bulletin 2025, sbaf096. PMID: 40579369, DOI: 10.1093/schbul/sbaf096.Peer-Reviewed Original ResearchDiffusion tensor imagingBrain measuresPolygenic scoresRs-fMRIPolygenic overlapResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingGenome-wide association study summary statisticsLinkage disequilibrium score regressionConcordant effect directionsConjunctional false discovery rateSNP-based heritabilityFunctional brain featuresBrain imaging phenotypesSchizophreniaBrain structuresFunctional connectivityBrain phenotypesGenetic overlapScore regressionBrain featuresComplex genetic relationshipsRs-fMRI measuresIndividual locus levelCausal variants