Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsChadi Abdallah, MD
Associate Professor Adjunct of PsychiatryAbout
Research
Publications
2025
Disrupted intrathalamic and thalamocortical structural covariance networks in posttraumatic stress disorder
Steele N, Hussain A, Sun D, Baird C, Russell C, Jahanshad N, Salminen L, Olff M, Frijling J, Veltman D, Koch S, Nawijn L, van Zuiden M, Wang L, Zhu Y, Li G, Stein D, Ipser J, Koopowitz S, Neria Y, Zhu X, Ravid O, Zilcha-Mano S, Lazarov A, Suarez-Jimenez B, Huggins A, Stevens J, Ressler K, Jovanovic T, van Rooij S, Fani N, Dennis E, Tate D, Cifu D, Walker W, Wilde E, Rektor I, Říha P, Kaufman M, Lebois L, Baker J, King A, Liberzon I, Angstadt M, Davenport N, Disner S, Sponheim S, Straube T, Hofmann D, Lu G, Qi R, Etkin A, Maron-Katz A, Wang X, Kunch A, Xie H, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa R, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Feola B, Blackford J, Olatunji B, May G, Nelson S, Gordon E, Abdallah C, Lanius R, Densmore M, Théberge J, Neufeld R, Thompson P, Morey R. Disrupted intrathalamic and thalamocortical structural covariance networks in posttraumatic stress disorder. Network Neuroscience 2025, 1-23. DOI: 10.1162/netn.a.535.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderStructural covariancePosttraumatic stress disorder severityComorbid depressive symptomsStructural covariance networksUnique facetsMemory-related functionsLateral cortical regionsOrbitofrontal cortexPTSD symptomatologyAvoidance symptomsDepression severityLimbic thalamusDepressive symptomsCovariance networksMotor preparationCortical regionsDifferential associationsThalamic functionThalamocortical networkThalamic nucleiCovariance patternsRegional alterationsHyperarousalCombining DNA Methylation Features and Clinical Characteristics Predicts Ketamine Treatment Response for PTSD
Valizadeh A, Roache J, Zhang X, Hu Y, Gueorguieva R, Averill L, Ranganathan M, Wang Z, Williamson D, Shiroma P, Girgenti M, Petrakis I, López-Roca A, Young-McCaughan S, Keane T, Peterson A, Abdallah C, Krystal J, Xu K, PTSD F. Combining DNA Methylation Features and Clinical Characteristics Predicts Ketamine Treatment Response for PTSD. IScience 2025, 114445. DOI: 10.1016/j.isci.2025.114445.Peer-Reviewed Original ResearchPost-traumatic stress disorderDNA methylation patternsDNA methylation featuresDNA methylation profilesStudies of ketamineBlood DNA methylation profilesBenefits of ketamineTreatment responseNear genesRisk lociMethylation sitesMethylation patternsMethylation featuresStress disorderMethylation profilesGlutamatergic signalingResponse subgroupsKetamineClinical measuresClinical variablesRandomized studyImmune regulationBiological variablesLociCpGsLower gyrification of the ventromedial prefrontal cortex in posttraumatic stress disorder - An ENIGMA-PTSD Study
Hussain A, Baird C, Huggins A, Russell C, Sun D, Rangel-Jimenez L, Abdallah C, Angstadt M, May G, Berg H, Blackford J, Cisler J, Daniels J, Davenport N, Davidson R, Densmore M, Disner S, El-Hage W, Etkin A, Fani N, Frijling J, Gordon E, Grupe D, Herringa R, Herzog J, Hofmann D, Hudson A, Jovanovic T, King A, Koch S, Lanius R, Lazarov A, Li, Liberzon I, Lissek S, Lu G, Manthey A, Maron-Katz A, McLaughlin K, Mueller S, Nawijn L, Nelson S, Neria Y, Neufeld R, Nitschke J, Olatunji B, Olff M, Peverill M, Qi R, Quidé Y, Ravid O, Rektor I, Ressler K, Říha P, Ross M, Sambrook K, Schmahl C, Sierk A, Sponheim S, Stevens J, Straube T, Suarez-Jimenez B, Théberge J, van der Wee N, van der Werff S, van Rooij S, van Zuiden M, Veltman D, Vermeiren R, Walter H, Wang L, Zhu X, Zhu Y, Zilcha-Mano S, Jahanshad N, Thompson P, Morey R. Lower gyrification of the ventromedial prefrontal cortex in posttraumatic stress disorder - An ENIGMA-PTSD Study. Biological Psychiatry Global Open Science 2025, 100679. DOI: 10.1016/j.bpsgos.2025.100679.Peer-Reviewed Original ResearchPosttraumatic stress disorderLocal gyrification indexRostral middle frontal cortexVentromedial prefrontal cortexMiddle frontal cortexPrefrontal cortexStress disorderFrontal cortexCortical gyrificationRight rostral anterior cingulate cortexComorbid posttraumatic stress disorderRostral anterior cingulate cortexInteraction of posttraumatic stress disorderModerating effect of depressionAnterior cingulate cortexMedial temporal cortexEffects of depressionModerating effectCortical surface areaPial surface areaVolumetric brain magnetic resonance imagingPTSD-onlyFear learningCingulate cortexPTSD diagnosisTurning Patients’ Open-Ended Narratives of Chronic Pain Into Quantitative Measures: Natural Language Processing Study
Norel R, Gewandter J, Zhang Z, Tahsin A, Abdallah C, Markman J, Duan Z, Cecchi G, Geha P. Turning Patients’ Open-Ended Narratives of Chronic Pain Into Quantitative Measures: Natural Language Processing Study. JMIR Human Factors 2025, 12: e80269. PMID: 41290220, PMCID: PMC12690277, DOI: 10.2196/80269.Peer-Reviewed Original ResearchConceptsChronic low back painVisual analog scaleChronic painPain QuestionnaireAnalog scaleCLBP intensitySubjective reports of painExperience of chronic painResponse to analgesicsLow back painHigher pain levelsNumerical rating scaleReports of painPatients' utterancesRating ScalePatient narrativesBack painPain levelsNatural language processingPainSubjective reportsPatientsGold standardQuality of lifePatient's personal narrativeMapping DNA methylation signatures to identify epigenetic variation across subcortical regions of the human PTSD brain
Li H, Liu Y, Shi Y, Wang J, Nguyen T, Xie Y, Zheng W, Cheng Y, Cruz D, Modliszewski J, Terwilliger R, Sliby A, Martínez-Magaña J, Montalvo-Ortiz J, Roache J, Averill L, Young-McCaughan S, Shiroma P, Huber B, Lewis D, Glausier J, Holtzheimer P, Friedman M, Zhang J, Peterson A, Abdallah C, Valizadeh A, Zhang X, Xu K, Krystal J, Duman R, Zhao H, Corcoran D, Williamson D, Girgenti M. Mapping DNA methylation signatures to identify epigenetic variation across subcortical regions of the human PTSD brain. Biological Psychiatry 2025 PMID: 41192574, DOI: 10.1016/j.biopsych.2025.10.032.Peer-Reviewed Original ResearchFear circuitryDNA methylationPost-traumatic stress disorderNeurobiology of PTSDTraumatic stress exposureDepressive disorder casesGene expressionSevere psychological traumaKetamine trialsPTSD patientsKetamine efficacyUnique biologyStress disorderDNA methylation signaturesCell typesMental disordersStress exposureSubcortical regionsPTSDPsychological traumaDisorder casesRNA-seqEpigenetic variationMethylation dataReference panelVolumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology
Steele N, Hussain A, Baird C, Haswell C, Sun D, Rangel-Jimenez L, Abdallah C, Angstadt M, May G, Berg H, Blackford J, Cisler J, Daniels J, Davenport N, Davidson R, Densmore M, Disner S, El-Hage W, Etkin A, Fani N, Frijling J, Gordon E, Grupe D, Herringa R, Hudson A, Jahanshad N, Jovanovic T, King A, Koch S, Lanius R, Lazarov A, Li G, Liberzon I, Lissek S, Lu G, Manthey A, Maron-Katz A, Nawijn L, Nelson S, Neria Y, Neufeld R, Nitschke J, Olatunji B, Olff M, Peverill M, Quidé Y, Ravid O, Rakesh G, Ressler K, Ross M, Sambrook K, Sierk A, Sponheim S, Stevens J, Suarez-Jimenez B, Théberge J, van Rooij S, van Zuiden M, Veltman D, Vermeiren R, Walter H, Wang L, Zhu X, Zhu Y, Zilcha-Mano S, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Cotton A, O'Leary E, Xie H, Wang X, Dennis E, Tate D, Cifu D, Walker W, Wilde E, Thompson P, Morey R. Volumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 41177253, DOI: 10.1016/j.bpsc.2025.10.016.Peer-Reviewed Original ResearchPosttraumatic stress disorder symptom clustersMajor depressive disorderPosttraumatic stress disorderMajor depressive disorder symptomsMajor depressive disorder severityPost-trauma psychopathologySymptom clustersThalamic nucleiThalamus volumeSeverity of posttraumatic stress disorderThalamic volumeDevelopment of posttraumatic stress disorderTrauma-exposed control participantsPosttraumatic stress disorder severityWhole thalamusVolume relative to controlsTrauma-exposed participantsChildhood trauma subtypesStructural brain MRI scansThalamic nuclei volumesRelative to controlsDepressive disorderTrauma subtypesNeurobiological mechanismsStress disorderImage-based meta- and mega-analysis (IBMMA): A unified framework for large-scale, multi-site, neuroimaging data analysis
Steele N, Huggins A, Morey R, Hussain A, Russell C, Suarez-Jimenez B, Pozzi E, Jameei H, Schmaal L, Veer I, Waller L, Jahanshad N, Thomopoulos S, Salminen L, Olff M, Frijling J, Veltman D, Koch S, Nawijn L, van Zuiden M, Wang L, Zhu Y, Li G, Stein D, Ipser J, Neria Y, Zhu X, Ravid O, Zilcha-Mano S, Lazarov A, Stevens J, Ressler K, Jovanovic T, van Rooij S, Fani N, Mueller S, Hudson A, Daniels J, Sierk A, Manthey A, Walter H, van der Wee N, van der Werff S, Vermeiren R, Schmahl C, Herzog J, Rektor I, Říha P, Kaufman M, Lebois L, Baker J, Rosso I, Olson E, King A, Liberzon I, Angstadt M, Davenport N, Disner S, Sponheim S, Straube T, Hofmann D, Lu G, Qi R, Wang X, Kunch A, Xie H, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce S, Cisler J, Ross M, Herringa R, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Tomas C, Fitzgerald J, Elman J, Panizzon M, Franz C, Lyons M, Kremen W, Feola B, Blackford J, Olatunji B, May G, Nelson S, Gordon E, Abdallah C, Lanius R, Densmore M, Théberge J, Neufeld R, Thompson P, Sun D. Image-based meta- and mega-analysis (IBMMA): A unified framework for large-scale, multi-site, neuroimaging data analysis. NeuroImage 2025, 322: 121554. PMID: 41138791, DOI: 10.1016/j.neuroimage.2025.121554.Peer-Reviewed Original ResearchConceptsLarge-scale datasetsTraditional softwareNeuroimaging data analysisMega-AnalysisMemory allocationParallel processingComputational speedNeuroimaging datasetsDatasetBrain regionsAnalysis toolsStatistical analysis toolsNeuroimaging findingsMulti-site studySoftware packageSoftwareNeuroimagingNeuroimaging featuresLarge-scaleFrameworkClinical utilityPythonBrainMulti-siteData analysisDynamic and Static Resting-State Functional Connectivity of Canonical Networks in Military and Civilian Populations with Posttraumatic Stress Disorder and/or Mild Traumatic Brain Injury
Dwulit A, Sun D, Haswell C, Hussain A, Dennis E, Wilde E, Newsome M, Tate D, Walker W, Abdallah C, Averill C, Blackford J, Olatunji B, King A, Liberzon I, Angstadt M, Rektor I, Říha P, Nečasová M, Fňašková M, Daniels J, Walter H, Manthey A, Sierk A, Olff M, van Zuiden M, Koch S, Veltman D, Frijiling J, Nawijn L, Jahanshad N, Thompson P, Morey R. Dynamic and Static Resting-State Functional Connectivity of Canonical Networks in Military and Civilian Populations with Posttraumatic Stress Disorder and/or Mild Traumatic Brain Injury. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40840859, DOI: 10.1016/j.bpsc.2025.08.002.Peer-Reviewed Original ResearchMild traumatic brain injuryPosttraumatic stress disorderDynamic functional connectivityStatic resting-state functional connectivitySalience networkStatic functional connectivityTraumatic brain injuryCentral executiveStress disorderComorbid subjectsFunctional connectivityFunctional connectomeMild traumatic brain injury groupInteraction effects of diagnosisAnxiety-related effectsExternally focused statesInteraction of diagnosisCanonical resting state networksBrain injuryEffect of diagnosisInteraction effectsDefault modeControl subjectsMilitary veteransDiagnostic groupsThe generative AI blueprint: modeling brain and behavior in concert
Abdallah C, van Dijk D. The generative AI blueprint: modeling brain and behavior in concert. Neuropsychopharmacology 2025, 51: 345-346. PMID: 40817169, PMCID: PMC12618471, DOI: 10.1038/s41386-025-02196-y.Peer-Reviewed Original ResearchData‐Driven Approach to Dynamic Resting State Functional Connectivity in Post‐Traumatic Stress Disorder: An ENIGMA‐PGC PTSD Study
Tomas C, Fitzgerald J, Baird C, Haswell C, Abdallah C, Angstadt M, Baker J, Berg H, Blackford J, Cisler J, Cotton A, Daniels J, Davenport N, Davidson R, deRoon‐Cassini T, Disner S, Hage W, Fani N, Frijling J, Gordon E, Grupe D, He X, Herringa R, Hofmann D, Huggins A, Hussain A, Ipser J, Jahanshad N, Jovanovic T, Kaufman M, Kim Y, King A, Koch S, Koopowitz S, Lazarov A, Lebois L, Liberzon I, Lissek S, Manthey A, May G, McLaughlin K, Nawijn L, Nelson S, Neria Y, Nitschke J, Olatunji B, Olff M, Peverill M, Quidé Y, Ravid O, Ressler K, Ross M, Salminen L, Sambrook K, Shih C, Sierk A, Sponheim S, Stein D, Stevens J, Straube T, Suarez‐Jimenez B, Thompson P, van der Wee N, van der Werff S, van Rooij S, van Zuiden M, Veltman D, Vermeiren R, Walter H, Wang X, Xie H, Zhu X, Zilcha‐Mano S, Larson C, Morey R. Data‐Driven Approach to Dynamic Resting State Functional Connectivity in Post‐Traumatic Stress Disorder: An ENIGMA‐PGC PTSD Study. Human Brain Mapping 2025, 46: e70116. PMID: 40736265, PMCID: PMC12308910, DOI: 10.1002/hbm.70116.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderFunctional magnetic resonance imagingBrain network dynamicsFunctional connectivityStress disorderTrauma typesBrain networksHeterogeneity of posttraumatic stress disorderSymptoms of posttraumatic stress disorderPost-traumatic stress disorderGroup independent component analysisNo group differencesIndependent component analysisResting-state networksStatic functional connectivityBrain network characteristicsMulti-cohort sampleData-driven analytic approachSample of traumaSymptom profilesConnectivity statesDiagnostic groupsGroup differencesStatic FCCognitive demands