2024
Diet quality, community food access, and glycemic control among nulliparous individuals with diabetes
Venkatesh K, Yee L, Wu J, Joseph J, Garner J, McNeil R, Scifres C, Mercer B, Reddy U, Silver R, Saade G, Parry S, Simhan H, Post R, Walker D, Grobman W. Diet quality, community food access, and glycemic control among nulliparous individuals with diabetes. Primary Care Diabetes 2024 PMID: 38972826, DOI: 10.1016/j.pcd.2024.06.011.Peer-Reviewed Original ResearchLarge-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy
Greenland P, Segal M, McNeil R, Parker C, Pemberton V, Grobman W, Silver R, Simhan H, Saade G, Ganz P, Mehta P, Catov J, Merz C, Varagic J, Khan S, Parry S, Reddy U, Mercer B, Wapner R, Haas D. Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy. JAMA Cardiology 2024, 9 PMID: 38958943, PMCID: PMC11223045, DOI: 10.1001/jamacardio.2024.1621.Peer-Reviewed Original ResearchArea under the receiver operating characteristic curveCase-control studyHypertensive disordersEarly pregnancyClinical dataSmall-for-gestational-age infantsPrediction of hypertensive disordersSmall-for-gestational-ageHypertensive disorders of pregnancyPrediction of HDPDisorders of pregnancyNested case-control studyPlasma samplesMulticenter observational studyStored plasma samplesReceiver operating characteristic curveBody mass indexGestational hypertensionNon-Hispanic blacksPreterm birthFetal sexFirst-trimesterNon-Hispanic whitesPregnancy outcomesMaternal racePre-conceptional Magnesium Intake and Low Birth Weight: Findings From the nuMoM2b Study
Kahe K, Zhang Y, Angley M, Reddy U. Pre-conceptional Magnesium Intake and Low Birth Weight: Findings From the nuMoM2b Study. Current Developments In Nutrition 2024, 8: 103076. DOI: 10.1016/j.cdnut.2024.103076.Peer-Reviewed Original ResearchPreconceptional Calcium Intake and Hypertensive Disorders of Pregnancy
Lu L, Zhang Y, Angley M, Reddy U, Fly A, Kahe K. Preconceptional Calcium Intake and Hypertensive Disorders of Pregnancy. Current Developments In Nutrition 2024, 8: 103292. DOI: 10.1016/j.cdnut.2024.103292.Peer-Reviewed Original ResearchAssociation of Maternal Zinc Intake With Hypertensive Disorders of Pregnancy: The nuMoM2b Study
Lu L, Zhang Y, Angley M, Reddy U, Fly A, Kahe K. Association of Maternal Zinc Intake With Hypertensive Disorders of Pregnancy: The nuMoM2b Study. Current Developments In Nutrition 2024, 8: 103018. DOI: 10.1016/j.cdnut.2024.103018.Peer-Reviewed Original ResearchRestless Legs Syndrome and Adverse Perinatal Outcomes
Friedlander R, Huang X, Kim M, Zee P, Khan S, Greenland P, Facco F, Chung J, Grobman W, Haas D, McNeil R, Mercer B, Reddy U, Saade G, Silver R, Wiener L, Yee L. Restless Legs Syndrome and Adverse Perinatal Outcomes. American Journal Of Obstetrics & Gynecology MFM 2024, 6: 101401. PMID: 38871296, DOI: 10.1016/j.ajogmf.2024.101401.Peer-Reviewed Original ResearchOptimizing Opioid Prescription Quantity After Cesarean Delivery: A Randomized Controlled Trial.
Smid M, Clifton R, Rood K, Srinivas S, Simhan H, Casey B, Longo M, Landau R, MacPherson C, Bartholomew A, Sowles A, Reddy U, Rouse D, Bailit J, Thorp J, Chauhan S, Saade G, Grobman W, Macones G. Optimizing Opioid Prescription Quantity After Cesarean Delivery: A Randomized Controlled Trial. Obstetrics And Gynecology 2024 PMID: 38857509, DOI: 10.1097/aog.0000000000005649.Peer-Reviewed Original ResearchOpioid tabletsCesarean birthOpioid useHuman Development Maternal-Fetal Medicine Units NetworkMaternal-Fetal Medicine Units NetworkPrimary outcomeQuantity of opioid tabletsEunice Kennedy Shriver National Institute of Child HealthOpioid prescription protocolPostcesarean pain managementHistory of opioid useOpioid prescription quantitiesRandomized controlled noninferiority trialNational Institute of Child HealthInstitute of Child HealthPostcesarean analgesiaCesarean deliveryRandomized controlled trialsPain managementPrescription quantitiesFollow-upWeeks postdischargeNoninferiority trialDecision makingChild healthDesign, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study
Group T, Scholtens D, LeBlanc E, Vesco K, Amy D, Bays K, Massimino S, Robinson S, Schell K, Walters G, Hillier T, Oshiro C, Cordero S, Howick C, Kim L, Martinez Y, Pishchalenko O, Wastlova V, Zork N, Mourad M, Lonier J, Reddy U, Acevedo J, Castillo J, Gomez M, Peguero B, Facco F, Feghali M, Bocan H, Stramowski S, Powe C, Edlow A, Barth W, Nathan D, Azevedo R, Baez A, Iroajanma C, Larkin M, Maya J, Michalopolous C, Neamonitaki N, Thangthaeng N, Yee L, Lowe W, Grobman W, Szmuilowicz E, Aguirre A, Guevara E, Mallett G, Matos S, Tyagi S, Spadola A, Catalano P, Azimirad A, Werner E, Rouse D, Malloy M, Parra F, Sherr J, Merriam A, Bitterman S, Considine E, Leventhal J, Perley L, Rink L, Steffen A, Thompson B, Zgorski M, Steffes M, Arends V, Killeen A, Siddique J, Bustamante P, Cheung Y, Freeze C, Grott T, Kuang A, Tull M, Linder B. Design, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study. BMJ Open 2024, 14: e084216. PMID: 38851233, PMCID: PMC11163666, DOI: 10.1136/bmjopen-2024-084216.Peer-Reviewed Original ResearchConceptsLarge-for-gestational-age birth weightMetabolic outcomesLarge-for-gestational-ageDiagnosis of gestational diabetesOral glucose tolerance testAdverse pregnancy outcomesVanderbilt University Institutional Review BoardCourse of pregnancyObservational cohort studyGlucose tolerance testNational Institute of DiabetesDigestive and Kidney DiseasesGDM treatmentWeeks gestationDetect such abnormalitiesPerinatal outcomesGDM screeningInstitutional review boardGestational diabetesFirst-trimesterPregnancy outcomesEarly pregnancyGlucose abnormalitiesBirth weightPregnant adultsInduction of labor versus expectant management among low-risk patients with one prior cesarean delivery
Ukoha E, Wen T, Reddy U. Induction of labor versus expectant management among low-risk patients with one prior cesarean delivery. American Journal Of Obstetrics And Gynecology 2024 PMID: 38852849, DOI: 10.1016/j.ajog.2024.06.001.Peer-Reviewed Original ResearchInduction of laborNeonatal morbidity compositeOperative vaginal deliveryMaternal morbidity compositeVaginal deliveryExposure of interestCesarean deliveryIntensive care unit admissionMorbidity compositeWeeks 6 daysWeeks 0 daysExpectant management groupLow-risk patientsPeripartum hysterectomyUterine ruptureLikelihood of vaginal deliveryRate of uterine ruptureUnit admissionElective induction of laborLog-binomial regression modelsBirth certificate dataConfidence intervalsExpectant managementAssociated with increased likelihoodNeonatal morbidity outcomesCannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. Obstetrical & Gynecological Survey 2024, 79: 307-309. DOI: 10.1097/ogx.0000000000001289.Peer-Reviewed Original ResearchAssociation of neighborhood social determinants of health and hypertensive disorders of pregnancy
Bank T, Lynch C, Yee L, Johnson J, Wu J, McNeil R, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Chung J, Wapner R, Grobman W, Venkatesh K. Association of neighborhood social determinants of health and hypertensive disorders of pregnancy. AJOG Global Reports 2024, 100372. DOI: 10.1016/j.xagr.2024.100372.Peer-Reviewed Original ResearchA Multi-Site Study to Develop and Validate First Trimester, Circulating Microparticle Biomarkers for Tiered Risk Stratification of Spontaneous Preterm Birth in Nulliparas
Rosenblatt K, Zhang Z, Doss R, Gurnani P, Grobman W, Silver R, Parry S, Reddy U, Cao S, Haas D. A Multi-Site Study to Develop and Validate First Trimester, Circulating Microparticle Biomarkers for Tiered Risk Stratification of Spontaneous Preterm Birth in Nulliparas. American Journal Of Obstetrics And Gynecology 2024 PMID: 38789072, DOI: 10.1016/j.ajog.2024.05.032.Peer-Reviewed Original ResearchIn vitro diagnostic multivariate index assaySpontaneous preterm birthGestational agePreterm birthLow riskModerate riskPrediction of spontaneous preterm birthHR groupRisk ratioHigh riskMonitoring Mothers-to-BeNulliparous Pregnancy Outcomes StudyTrimester of pregnancyMultivariate index assayPregnancy Outcomes StudyNested case-control designStatistically significant differencePregnant patientsWeeks gestationMass spectrometry assayCase-control designRisk stratificationStratify riskMothers-to-beStratification toolStillbirth: We can do better
Silver R, Reddy U. Stillbirth: We can do better. American Journal Of Obstetrics And Gynecology 2024 PMID: 38789073, DOI: 10.1016/j.ajog.2024.05.042.Peer-Reviewed Original ResearchResource countriesNon-Hispanic blacksPrevention of stillbirthNon-Hispanic whitesOther Pacific IslanderRate of stillbirthLow-income countriesStillbirth rateStillbirthRisk factorsPacific IslandersGenetic etiologyPlacental assessmentEmotion managementRisk stratificationPreventionUnited StatesPregnancyRiskDisparitiesEpidemiologyCountriesU.S.WhiteSocioeconomic Disadvantage in Pregnancy and Postpartum Risk of Cardiovascular Disease
Venkatesh K, Khan S, Catov J, Wu J, McNeil R, Greenland P, Wu J, Levine L, Yee L, Simhan H, Haas D, Reddy U, Saade G, Silver R, Merz C, Grobman W. Socioeconomic Disadvantage in Pregnancy and Postpartum Risk of Cardiovascular Disease. American Journal Of Obstetrics And Gynecology 2024 PMID: 38759711, DOI: 10.1016/j.ajog.2024.05.007.Peer-Reviewed Original ResearchSocial determinants of healthArea Deprivation IndexNeighborhood-level socioeconomic disadvantageSocioeconomic disadvantageSocial determinantsFramingham risk scoreRisk scoreCardiovascular diseaseNeighborhood-level social determinantsModified Poisson regression modelsDeterminants of healthParticipant's home addressMedian area deprivation indexMaternal cardiovascular healthPoisson regression modelsLong-term cardiovascular diseaseRisk of cardiovascular diseaseMothers-to-bePredicted riskRisk of ASCVDCensus block levelRisk of long-term cardiovascular diseaseMultivariate linear regressionDeprivation indexNulliparous individualsGenetic polymorphisms associated with adverse pregnancy outcomes in nulliparas
Khan R, Guerrero R, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas. Scientific Reports 2024, 14: 10514. PMID: 38714721, PMCID: PMC11076516, DOI: 10.1038/s41598-024-61218-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAdverse pregnancy outcomesMulti-ancestry genome-wide association studyCluster of SNPsGestational diabetesPregnancy outcomesAdmixed AmericansNovel lociPregnancy lossAssociation studiesGenetic markersIncreased risk of pregnancy lossTRMU geneGenetic ancestryAssociated with gestational diabetesRisk of pregnancy lossSub-cohortProportion of pregnanciesCause of morbidityLociAssociation TestSNPsPreterm birthMaternal riskIncreased riskPregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks Gestation
Woolcock H, Parra N, Zhang Y, Reddy U, Bello N, Miller E, Booker W. Pregnancy Outcomes in Women Who Developed Elevated Blood Pressure and Stage I Hypertension after 20 Weeks Gestation. American Journal Of Perinatology 2024 PMID: 38569509, DOI: 10.1055/a-2298-5347.Peer-Reviewed Original ResearchAssociated with adverse pregnancy outcomesFetal growth restrictionPlacental abruptionWeeks gestationBlood pressureElevated BPAmerican Heart AssociationPregnancy outcomesNormal BPOdds of fetal growth restrictionIncreased riskOdds of placental abruptionAmerican CollegeMultivariable-adjusted odds ratioAssociated with HDPAdverse pregnancy outcomesWeeks of pregnancyProspective cohort studyElevated blood pressureConfidence intervalsStage I hypertensionAmerican College of Cardiology (ACCCesarean deliveryPreterm deliverySingleton pregnanciesAdverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery
Venkatesh K, Khan S, Yee L, Wu J, McNeil R, Greenland P, Chung J, Levine L, Simhan H, Catov J, Scifres C, Reddy U, Pemberton V, Saade G, Merz C, Grobman W, Mothers-to-Be A. Adverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery. Obstetrics And Gynecology 2024, 143: 775-784. PMID: 38574364, PMCID: PMC11098696, DOI: 10.1097/aog.0000000000005569.Peer-Reviewed Original ResearchConceptsRisk of atherosclerotic CVDAtherosclerotic CVD riskAdverse pregnancy outcomesHypertensive disorders of pregnancyAtherosclerotic CVDCVD riskDisorders of pregnancyPregnancy outcomesHypertensive disordersPreterm birthModified Poisson modelsFramingham risk scoreRisk of CVDRisk of atherosclerotic cardiovascular diseaseMagnitude of riskAbsolute riskAtherosclerotic cardiovascular diseaseSecondary analysisLongitudinal cohortRisk scoreGestational ageGreater riskBaseline covariatesCardiovascular diseaseDisease 2Prediction of metabolic syndrome following a first pregnancy
Kawakita T, Greenland P, Pemberton V, Grobman W, Silver R, Bairey Merz C, McNeil R, Haas D, Reddy U, Simhan H, Saade G. Prediction of metabolic syndrome following a first pregnancy. American Journal Of Obstetrics And Gynecology 2024 PMID: 38527600, DOI: 10.1016/j.ajog.2024.03.031.Peer-Reviewed Original ResearchDevelopment of metabolic syndromeArea under the receiver operating characteristic curveMetabolic syndromeNational Cholesterol Education Program Adult Treatment Panel III criteriaAdult Treatment Panel III criteriaPrevalence of metabolic syndromePrediction of metabolic syndromeProspective cohort studyIn-personSecondary analysisCohort studyIII criteriaInclusion criteriaPregnant individualsPrimary outcomeReceiver operating characteristic curveVisit 2Regression modelsPregnancySyndromeDeliveryUnited StatesCharacteristic curveLASSO regression modelYearsInfection and Sepsis Trends during United States' Delivery Hospitalizations from 2000 to 2020
Liu L, Friedman A, Goffman D, Nathan L, Sheen J, Reddy U, D'Alton M, Wen T. Infection and Sepsis Trends during United States' Delivery Hospitalizations from 2000 to 2020. American Journal Of Perinatology 2024 PMID: 38408480, DOI: 10.1055/s-0044-1780538.Peer-Reviewed Original ResearchChronic health conditionsChronic condition diagnosesSevere maternal morbidityDelivery hospitalizationsHealth conditionsAdverse obstetric outcomesMaternal morbidityWound infectionAssociated with chronic health conditionsInfection diagnosisStudy periodObstetric outcomesEvaluate trendsCross-sectional analysisLogistic regression modelsMeasures of associationNational Inpatient SampleChronic conditionsHospital characteristicsAcute renal failureHospitalization of patientsPresence of sepsisOdds ratioCondition diagnosisInpatient SamplePostpartum Readmission Risk: A Comparison between Stillbirths and Live Births
Sweeney L, Reddy U, Campbell K, Xu X. Postpartum Readmission Risk: A Comparison between Stillbirths and Live Births. American Journal Of Obstetrics And Gynecology 2024 PMID: 38367754, DOI: 10.1016/j.ajog.2024.02.017.Peer-Reviewed Original ResearchRisk of readmissionMental health/substance use disordersPostpartum readmissionHigher risk of readmissionLive birthsRisk of postpartum readmissionSecondary outcomesDelivery characteristicsNationally representative estimatesComplex sampling designRisk factorsIncreased maternal morbidityHigher household incomeTime of readmissionWeeks of dischargeHypertensive disorders of pregnancyUse disorderHigh riskVenous thromboembolismChildbirth hospitalizationPrimary cesareanSingleton stillbirthsDisorders of pregnancyMultivariate regression modelMaternal morbidity