2024
A Multi-Site Study to Develop and Validate First Trimester, Circulating Microparticle Biomarkers for Tiered Risk Stratification of Spontaneous Preterm Birth in Nulliparas
Rosenblatt K, Zhang Z, Doss R, Gurnani P, Grobman W, Silver R, Parry S, Reddy U, Cao S, Haas D. A Multi-Site Study to Develop and Validate First Trimester, Circulating Microparticle Biomarkers for Tiered Risk Stratification of Spontaneous Preterm Birth in Nulliparas. American Journal Of Obstetrics And Gynecology 2024 PMID: 38789072, DOI: 10.1016/j.ajog.2024.05.032.Peer-Reviewed Original ResearchIn vitro diagnostic multivariate index assaySpontaneous preterm birthGestational agePreterm birthLow riskModerate riskPrediction of spontaneous preterm birthHR groupRisk ratioHigh riskMonitoring Mothers-to-BeNulliparous Pregnancy Outcomes StudyTrimester of pregnancyMultivariate index assayPregnancy Outcomes StudyNested case-control designStatistically significant differencePregnant patientsWeeks gestationMass spectrometry assayCase-control designRisk stratificationStratify riskMothers-to-beStratification tool
2023
Comparing population-based fetal growth standards in a US cohort
Gleason J, Reddy U, Chen Z, Grobman W, Wapner R, Steller J, Simhan H, Scifres C, Blue N, Parry S, Grantz K. Comparing population-based fetal growth standards in a US cohort. American Journal Of Obstetrics And Gynecology 2023 PMID: 38151220, PMCID: PMC11196385, DOI: 10.1016/j.ajog.2023.12.034.Peer-Reviewed Original ResearchComposite perinatal morbidityFetal growth standardsPerinatal morbidityNeonatal morbidityWorld Health OrganizationGrowth standardsEunice Kennedy Shriver National InstituteNulliparous Pregnancy Outcomes StudyHighest AUCComposite neonatal morbiditySubsequent neonatal morbidityU.S. clinical centersFetal growth restrictionRisk of morbidityRace/Management of pregnancyPregnancy Outcomes StudyAntenatal monitoringNulliparous womenFetal weightFirst trimesterVisit 2Visit 3US cohortClinical centersCannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. JAMA 2023, 330: 2191-2199. PMID: 38085313, PMCID: PMC10716715, DOI: 10.1001/jama.2023.21146.Peer-Reviewed Original ResearchConceptsPrimary composite outcomeAdverse pregnancy outcomesComposite outcomeFirst trimesterCannabis exposurePregnancy outcomesCannabis usePlacental functionPropensity score-weighted analysisNulliparous Pregnancy Outcomes StudyOngoing exposureMaternal cannabis useUrine cotinine assayUrine samplesMedical record abstractionPregnancy outcome dataGestational-age birthsBody mass indexGestational age windowsPregnancy Outcomes StudyUS medical centersOngoing cannabis useAdjudication of outcomesMaternal cannabisHypertensive disordersCommunity-level social determinants of health and pregestational and gestational diabetes
Field C, Grobman W, Yee L, Johnson J, Wu J, McNeil B, Mercer B, Simhan H, Reddy U, Silver R, Parry S, Saade G, Chung J, Wapner R, Lynch C, Venkatesh K. Community-level social determinants of health and pregestational and gestational diabetes. American Journal Of Obstetrics & Gynecology MFM 2023, 6: 101249. PMID: 38070680, PMCID: PMC11184512, DOI: 10.1016/j.ajogmf.2023.101249.Peer-Reviewed Original ResearchCommunity-level social determinantsGestational diabetesPregestational diabetesAdverse social determinantsSocial determinantsSocioeconomic disadvantageNulliparous Pregnancy Outcomes StudyGestational diabetes diagnosisArea deprivation index scoreMedicaid insurance statusRisk of diabetesPregnancy Outcomes StudyWalkable neighborhoodsDeprivation index scoreArea Deprivation IndexLower household incomeFood desertsGreater socioeconomic disadvantageChronic hypertensionHighest tertileFirst trimesterHigher socioeconomic disadvantageInsurance statusMonitoring MothersMultinomial logistic regressionSodium intake and the development of hypertensive disorders of pregnancy
Bank T, Grasch J, Chung J, Mercer B, McNeil R, Parry S, Saade G, Shanks A, Silver R, Simhan H, Yee L, Reddy U, Grobman W, Frey H. Sodium intake and the development of hypertensive disorders of pregnancy. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101166. PMID: 37741626, DOI: 10.1016/j.ajogmf.2023.101166.Peer-Reviewed Original ResearchConceptsHypertensive disordersHigh sodium intakeSodium intakeChronic hypertensionNonpregnant populationLow platelet count syndromeNeonatal intensive care unitNulliparous Pregnancy Outcomes StudyElevated liver enzymesGestational age neonatesFood frequency questionnaireLow sodium intakeIncidence risk ratioIntensive care unitWeeks of gestationPregnancy Outcomes StudyLack of associationChi-square testGestational hypertensionNeonatal outcomesNonpregnant stateSodium restrictionFrequency questionnairePreterm birthSingleton pregnanciesSearching and visualizing genetic associations of pregnancy traits by using GnuMoM2b
Yan Q, Guerrero R, Khan R, Surujnarine A, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Blue N, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b. Genetics 2023, 225: iyad151. PMID: 37602697, PMCID: PMC10691790, DOI: 10.1093/genetics/iyad151.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesNulliparous Pregnancy Outcomes StudyPregnancy Outcomes StudyMajor risk factorGenome-wide association studiesPregnancy outcomesGenetic associationMonitoring MothersRisk factorsOutcome studiesWomen's healthPhenome-wide association studySingle nucleotide polymorphismsAssociation studiesGenetic resultsPregnancyNucleotide polymorphismsRisk factors and perinatal outcomes for persistent placenta previa in nulliparas
Post R, Chang J, Ziogas A, Crosland B, Silver R, Haas D, Grobman W, Saade G, Reddy U, Simhan H, Chung J. Risk factors and perinatal outcomes for persistent placenta previa in nulliparas. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101136. PMID: 37598887, DOI: 10.1016/j.ajogmf.2023.101136.Peer-Reviewed Original ResearchPersistent placenta previaPlacenta previaMidtrimester ultrasoundRisk factorsPrevious pregnancyCesarean deliveryMaternal ageNulliparous Pregnancy Outcomes StudyLower neonatal birthweightOlder maternal agePrevious cesarean deliveryProspective cohort studyPregnancy Outcomes StudySignificant risk factorsMultivariate logistic regressionNulliparous individualsPrevious dilationNeonatal birthweightNeonatal outcomesPerinatal outcomesPreterm deliveryBaseline characteristicsCohort studyThird trimesterAntepartum admissionsAssociation of maternal body mass index with success and outcomes of attempted operative vaginal delivery
Grasch J, Venkatesh K, Grobman W, Silver R, Saade G, Mercer B, Yee L, Scifres C, Parry S, Simhan H, Reddy U, Frey H. Association of maternal body mass index with success and outcomes of attempted operative vaginal delivery. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101081. PMID: 37422004, DOI: 10.1016/j.ajogmf.2023.101081.Peer-Reviewed Original ResearchConceptsMaternal body mass indexBody mass indexOperative vaginal deliveryVaginal delivery attemptComposite maternal morbidityComposite neonatal morbidityVaginal deliveryMass indexNeonatal morbidityCesarean deliveryMaternal morbidityAdverse outcomesSecond-stage cesarean deliveryBody mass index groupsBody mass index categoriesNulliparous Pregnancy Outcomes StudyNonanomalous singleton pregnanciesNeonatal adverse outcomesMultivariable logistic regressionPregnancy Outcomes StudyNulliparous individualsDose-dependent mannerSecondary outcomesSingleton pregnanciesPrimary outcomeAssociation of Living in a Food Desert and Poor Periconceptional Diet Quality in a Cohort of Nulliparous Pregnant Individuals
Venkatesh K, Walker D, Yee L, Wu J, Garner J, McNeil B, Haas D, Mercer B, Reddy U, Silver R, Wapner R, Saade G, Parry S, Simhan H, Lindsay K, Grobman W. Association of Living in a Food Desert and Poor Periconceptional Diet Quality in a Cohort of Nulliparous Pregnant Individuals. Journal Of Nutrition 2023, 153: 2432-2441. PMID: 37364682, PMCID: PMC10447609, DOI: 10.1016/j.tjnut.2023.06.032.Peer-Reviewed Original ResearchConceptsDiet qualityPregnant individualsDietary qualityNulliparous Pregnancy Outcomes StudyWorse dietary qualityAdverse pregnancy outcomesHealthy Eating IndexPregnancy Outcomes StudyAdverse social determinantsFood desertsPregnancy outcomesProspective cohortTotal vegetablesMean HEIMonitoring MothersLowest quartileOutcome studiesPoor dietExcess intakeEmpty caloriesSocial determinantsAdequacy componentsAssessed individualsSupermarket accessFood access indicators