2023
Thoracic Endovascular Aortic Repair vs Medical Therapy Alone for Uncomplicated Acute Type B Aortic Dissection
Hu K, Pupovac S, Hameed I, Zafar M, Fereydooni S, Li E, Ma W, Williams M, Assi R, Nassiri N, Vallabhajosyula P. Thoracic Endovascular Aortic Repair vs Medical Therapy Alone for Uncomplicated Acute Type B Aortic Dissection. Journal Of Vascular Surgery 2023, 77: e270. DOI: 10.1016/j.jvs.2023.03.378.Peer-Reviewed Original Research
2022
mTOR inhibition prevents angiotensin II–induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice
He C, Jiang B, Wang M, Ren P, Murtada SI, Caulk AW, Li G, Qin L, Assi R, Lovoulos CJ, Schwartz MA, Humphrey JD, Tellides G. mTOR inhibition prevents angiotensin II–induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice. JCI Insight 2022, 7: e155815. PMID: 35132962, PMCID: PMC8855820, DOI: 10.1172/jci.insight.155815.Peer-Reviewed Original ResearchConceptsApoE-deficient miceAngiotensin IIVascular wall cellsAortic tearAortic ruptureMTOR inhibitionSmooth muscle cell hypertrophyMatricellular proteinWall cellsSuprarenal abdominal aortaMuscle cell hypertrophyExtracellular matrix accumulationInhibition of mTORRole of mTORSubadventitial hematomaFree ruptureAortic dissectionAortic diseaseAortic aneurysmSignificant dissectionAbdominal aortaHemorrhagic lesionsExtensive dissectionMetalloproteinase expressionCell hypertrophy
2021
Socioeconomic disparities in surveillance and follow‐up of patients with thoracic aortic aneurysm
Shang M, Weininger G, Mori M, Kahler‐Quesada A, Degife E, Brooks C, Yousef S, Williams M, Assi R, Geirsson A, Vallabhajosyula P. Socioeconomic disparities in surveillance and follow‐up of patients with thoracic aortic aneurysm. Journal Of Cardiac Surgery 2021, 37: 831-839. PMID: 34873754, DOI: 10.1111/jocs.16173.Peer-Reviewed Original ResearchConceptsAortic aneurysmArea Deprivation IndexCardiovascular specialistsSocioeconomic statusSurgical interventionAneurysm sizeReferral of patientsRisk of deathSignificant risk factorsThoracic aortic aneurysmComputed tomography scanLowest socioeconomic quartileLow socioeconomic statusLower Socioeconomic StatusADI quartileAortic surveillanceAortic dissectionConsecutive patientsPrimary outcomeSpecialist referralSurgical repairTimely followSurveillance imagingRisk regressionRisk factorsDevelopment and Validation of a Predictive Model to Identify Patients With an Ascending Thoracic Aortic Aneurysm
Mori M, Gan G, Deng Y, Yousef S, Weininger G, Daggula KR, Agarwal R, Shang M, Assi R, Geirsson A, Vallabhajosyula P. Development and Validation of a Predictive Model to Identify Patients With an Ascending Thoracic Aortic Aneurysm. Journal Of The American Heart Association 2021, 10: e022102. PMID: 34743563, PMCID: PMC8751931, DOI: 10.1161/jaha.121.022102.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic aneurysmPatient riskTomography scanHigher body surface areaTertiary care centerAortic valve diseaseHistory of arrhythmiaAvailable clinical informationBody surface areaScreening of patientsCross-sectional studyRisk prediction algorithmAscending Thoracic Aortic AneurysmsLogistic regression modelsClinical characteristicsAortic dissectionUnique patientsValve diseaseC-statisticFemale sexThoracic aortaCare centerComorbidity variablesMultivariable modelManagement of Chronic Descending Thoracic and Thoracoabdominal Dissection and Aneurysm - Stent Grafting, Debranching
Assi R, Szeto W. Management of Chronic Descending Thoracic and Thoracoabdominal Dissection and Aneurysm - Stent Grafting, Debranching. 2021, 409-422. DOI: 10.1007/978-3-030-66668-2_29.Peer-Reviewed Original ResearchChronic type B aortic dissectionType B aortic dissectionB aortic dissectionEndovascular repairAortic dissectionTreatment modalitiesFalse lumen thrombosisOnly treatment modalityOpen surgical reconstructionDifferent treatment modalitiesStent-graft devicesDescending ThoracicThoracoabdominal dissectionAortic remodelingPerioperative morbidityEntry tearSurgical reconstructionAortic anatomyAortic degenerationNatural historyDissectionDiseaseComplex diseasesModalitiesComplex casesFrozen elephant trunk and hemiarch for type A aortic dissection
Singh S, Yousef S, Assi R, Vallabhajosyula P. Frozen elephant trunk and hemiarch for type A aortic dissection. Journal Of Visualized Surgery 2021, 0: 0-0. DOI: 10.21037/jovs-20-85.Peer-Reviewed Original ResearchThis video demonstrates step by step hemiarch reconstruction and frozen elephant trunk repair of a patient with type A aortic dissection
Singh S, Yousef S, Assi R, Vallabhajosyula P. This video demonstrates step by step hemiarch reconstruction and frozen elephant trunk repair of a patient with type A aortic dissection. ASVIDE 2021, 8: 315-315. DOI: 10.21037/asvide.2021.315.Peer-Reviewed Original ResearchCommentary: Management of acute type A aortic dissection with patent false lumen: A rivalry between surgical data and philosophy
Hameed I, Geirsson A, Assi R. Commentary: Management of acute type A aortic dissection with patent false lumen: A rivalry between surgical data and philosophy. JTCVS Techniques 2021, 9: 13-14. PMID: 34647044, PMCID: PMC8501187, DOI: 10.1016/j.xjtc.2021.06.022.Commentaries, Editorials and Letters
2020
Midterm outcomes and durability of sinus segment preservation compared with root replacement for acute type A aortic dissection
Bojko MM, Assi R, Bavaria JE, Suhail M, Habertheuer A, Hu RW, Harmon J, Milewski RK, Desai ND, Szeto WY, Vallabhajosyula P. Midterm outcomes and durability of sinus segment preservation compared with root replacement for acute type A aortic dissection. Journal Of Thoracic And Cardiovascular Surgery 2020, 163: 900-910.e2. PMID: 32620395, DOI: 10.1016/j.jtcvs.2020.04.064.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAgedAortic AneurysmAortic DissectionAortic ValveAortic Valve InsufficiencyBlood Vessel Prosthesis ImplantationCardiac Surgical ProceduresFemaleHumansMaleMiddle AgedPostoperative ComplicationsRecurrenceReoperationRetrospective StudiesRisk AssessmentRisk FactorsSinus of ValsalvaTime FactorsTreatment OutcomeConceptsAcute typeRoot replacementAortic dissectionAortic insufficiencyRoot repairCumulative incidenceReplacement groupPostoperative aortic insufficiencyProximal aortic reoperationsRoot replacement groupMultivariable Cox regressionSinus of ValsalvaLongitudinal mixed modelsAortic reoperationValsalva dimensionsMidterm outcomesRoot dilationCox regressionFunctional outcomeRisk factorsReoperationSinusInsufficiencyDissectionMixed effects models
2018
Techniques and outcomes of secondary open repair for chronic dissection after acute repair of type A aortic dissection.
Assi R, Bavaria JE, Desai ND. Techniques and outcomes of secondary open repair for chronic dissection after acute repair of type A aortic dissection. The Journal Of Cardiovascular Surgery 2018, 59: 759-766. PMID: 29943963, DOI: 10.23736/s0021-9509.18.10646-x.Peer-Reviewed Original ResearchConceptsAortic dissectionSecondary open repairThoraco-abdominal aortaDistal false lumenRisk of ruptureAcute TAADChronic dissectionAcceptable morbidityAcute typeAcute repairPrimary tearDistal aortaOpen repairAneurysmal dilatationFalse lumenDistal reoperationExperienced handsIndex operationProgressive degenerationSuccessful repairAortaDissectionHybrid procedureRepairReoperation