2018
Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial
D'Souza DC, Cortes-Briones J, Creatura G, Bluez G, Thurnauer H, Deaso E, Bielen K, Surti T, Radhakrishnan R, Gupta A, Gupta S, Cahill J, Sherif MA, Makriyannis A, Morgan PT, Ranganathan M, Skosnik PD. Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. The Lancet Psychiatry 2018, 6: 35-45. PMID: 30528676, DOI: 10.1016/s2215-0366(18)30427-9.Peer-Reviewed Original ResearchConceptsPF-04457845Cannabis withdrawal symptomsFatty acid amide hydrolaseCannabis withdrawalPlacebo groupAdverse eventsCannabis useWithdrawal symptomsFatty acid amide hydrolase inhibitorSerious adverse eventsPhase 2a trialWeeks of treatmentTreatment of cannabisCannabis use disorderSelf-reported cannabis useDSM-IV criteriaTreatment-related differencesTHC-COOH concentrationsAnandamide concentrationsTreat populationPrimary endpointPill countHospital admissionNovel FAAH inhibitorsSelf-reported cannabis
2010
Lucid dreaming and ventromedial versus dorsolateral prefrontal task performance
Neider M, Pace-Schott EF, Forselius E, Pittman B, Morgan PT. Lucid dreaming and ventromedial versus dorsolateral prefrontal task performance. Consciousness And Cognition 2010, 20: 234-244. PMID: 20829072, PMCID: PMC3026881, DOI: 10.1016/j.concog.2010.08.001.Peer-Reviewed Original ResearchGender‐Related Influences of Parental Alcoholism on the Prevalence of Psychiatric Illnesses: Analysis of the National Epidemiologic Survey on Alcohol and Related Conditions
Morgan PT, Desai RA, Potenza MN. Gender‐Related Influences of Parental Alcoholism on the Prevalence of Psychiatric Illnesses: Analysis of the National Epidemiologic Survey on Alcohol and Related Conditions. Alcohol Clinical And Experimental Research 2010, 34: 1759-1767. PMID: 20645936, PMCID: PMC2950877, DOI: 10.1111/j.1530-0277.2010.01263.x.Peer-Reviewed Original ResearchConceptsPsychiatric illnessParental alcoholismPaternal alcoholismMale offspringGender of offspringOffspring psychiatric disordersGender-specific prevalenceFemale offspringAdjusted odds ratioNational Epidemiologic SurveyNational Epidemiological SurveyGender-related differencesMaternal alcoholismOdds ratioHigh prevalenceOffspring of individualsAxis IPsychiatric disordersRelated Conditions dataEpidemiologic SurveyEpidemiological surveyGreater riskFemale childrenRelated conditionsGender-related influences
2009
Regulation of cocaine self-administration in humans: Lack of evidence for loading and maintenance phases
Angarita GA, Pittman B, Gueorguieva R, Kalayasiri R, Lynch WJ, Sughondhabirom A, Morgan PT, Malison RT. Regulation of cocaine self-administration in humans: Lack of evidence for loading and maintenance phases. Pharmacology Biochemistry And Behavior 2009, 95: 51-55. PMID: 20005893, PMCID: PMC2824073, DOI: 10.1016/j.pbb.2009.12.005.Peer-Reviewed Original Research
2006
Self-reported paranoia during laboratory “binge” cocaine self-administration in humans
Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Morgan PT, Cubells JF, Malison RT. Self-reported paranoia during laboratory “binge” cocaine self-administration in humans. Pharmacology Biochemistry And Behavior 2006, 83: 249-256. PMID: 16549106, DOI: 10.1016/j.pbb.2006.02.005.Peer-Reviewed Original ResearchConceptsCocaine-induced paranoiaIntravenous cocaine self-administration sessionsPlacebo-controlled designCocaine self-administration sessionsCocaine-dependent volunteersSelf-administration sessionsTest-retest sessionsCocaine doseHigh dosesCocaine useSignificant main effectDoseDosesSelf-reported paranoiaSubjectsVulnerable subjects