2024
Nonadjuvanted Bivalent Respiratory Syncytial Virus Vaccination and Perinatal Outcomes
Son M, Riley L, Staniczenko A, Cron J, Yen S, Thomas C, Sholle E, Osborne L, Lipkind H. Nonadjuvanted Bivalent Respiratory Syncytial Virus Vaccination and Perinatal Outcomes. JAMA Network Open 2024, 7: e2419268. PMID: 38976271, PMCID: PMC11231799, DOI: 10.1001/jamanetworkopen.2024.19268.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusNeonatal intensive care unitPreterm birthWeeks gestationRisk of HDPPerinatal outcomesLogistic regression modelsIncreased riskPregnant individualsPrenatal vaccinationSmall-for-gestational age birth weightNeonatal intensive care unit admissionCohort studyIncreased risk of PTBOdds ratioIncreased risk of HDPRisk of preterm birthRespiratory syncytial virus seasonRespiratory syncytial virus vaccineRetrospective observational cohort studyNeonatal respiratory distressVaccination statusMultivariate logistic regression modelObservational cohort studyCox regression modelsCo-existing chronic hypertension and hypertensive disorders of pregnancy and associated adverse pregnancy outcomes
Sweeney L, Lundsberg L, Culhane J, Partridge C, Son M. Co-existing chronic hypertension and hypertensive disorders of pregnancy and associated adverse pregnancy outcomes. The Journal Of Maternal-Fetal & Neonatal Medicine 2024, 37: 2305675. PMID: 38290827, DOI: 10.1080/14767058.2024.2305675.Peer-Reviewed Original ResearchConceptsHypertensive disorders of pregnancyDisorders of pregnancyNeonatal outcomesChronic hypertensionHypertensive disordersIntensive care unitCesarean deliveryOdds of cesarean deliveryPregnant personsBlood pressureBivariate tests of associationHypertensive conditionsMaternal ICU admissionPreterm birth <Intensive care unit admissionAntihypertensive medication useBaseline clinical dataElectronic medical recordsTests of associationRetrospective cohort studySGA birthweightEligible peopleGestational ageMaternal comorbiditiesSingleton deliveries
2023
The association between a low 50-gram, 1-hour glucose challenge test value and neonatal morbidity
Ding J, Lundsberg L, Culhane J, Patridge C, Milley L, Son M. The association between a low 50-gram, 1-hour glucose challenge test value and neonatal morbidity. The Journal Of Maternal-Fetal & Neonatal Medicine 2023, 36: 2245527. PMID: 37558273, DOI: 10.1080/14767058.2023.2245527.Peer-Reviewed Original ResearchConceptsGlucose challenge test valuesTertiary care academic hospitalDiagnosis of GDMGlycemic screeningGCT valuesNICU admissionNeonatal outcomesMorbidity outcomesAcademic hospitalNeonatal intensive care unit admissionSingle tertiary care academic hospitalIntensive care unit admissionMultivariable logistic regression modelingComposite morbidity outcomeNeonatal morbidity outcomesCare unit admissionRetrospective cohort studyNewborns of mothersRisk of morbidityLogistic regression modelingEligible patientsUnit admissionAntenatal surveillanceGestational diabetesHypertensive disordersFetal growth restriction and small for gestational age as predictors of neonatal morbidity: which growth nomogram to use?
Leon-Martinez D, Lundsberg L, Culhane J, Zhang J, Son M, Reddy U. Fetal growth restriction and small for gestational age as predictors of neonatal morbidity: which growth nomogram to use? American Journal Of Obstetrics And Gynecology 2023, 229: 678.e1-678.e16. PMID: 37348779, DOI: 10.1016/j.ajog.2023.06.035.Peer-Reviewed Original ResearchConceptsNeonatal composite outcomeComposite outcomeFetal growth restrictionGestational ageFetal weightWeeks of gestationPositive likelihood ratioGrowth restrictionNonanomalous singleton pregnanciesPoor neonatal outcomeRetrospective cohort studySingle academic centerWeeks of deliveryDays of deliveryFetal growth referencesElectronic medical recordsProportion of fetusesLikelihood ratioNeonatal morbidityNeonatal outcomesPerinatal outcomesCohort studySingleton pregnanciesNeonatal dataMedical recordsAntibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes
Snider J, Mithal L, Kwah J, Rhodes N, Son M. Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes. BMC Pregnancy And Childbirth 2023, 23: 400. PMID: 37254067, PMCID: PMC10228028, DOI: 10.1186/s12884-023-05697-0.Peer-Reviewed Original ResearchConceptsGroup B streptococcus prophylaxisReported penicillin allergyPenicillin allergyGBS prophylaxisLab drawsNeonatal outcomesNewborn outcomesAntibiotic administrationMedical recordsPregnant individualsIntrapartum group B streptococcus prophylaxisNeonatal intensive care unit admissionDesignThis retrospective cohort studyIntensive care unit admissionSelf-reported penicillin allergyNeonates of mothersCare unit admissionIntrapartum antibiotic prophylaxisRetrospective cohort studyWeeks of gestationMother-infant pairsMother-infant dyadsBeta-lactam antibioticsAntibiotic prophylaxisUnit admissionIntravenous iron for treatment of iron deficiency anemia during pregnancy and associated maternal outcomes
Burn M, Lundsberg L, Culhane J, Partridge C, Son M. Intravenous iron for treatment of iron deficiency anemia during pregnancy and associated maternal outcomes. The Journal Of Maternal-Fetal & Neonatal Medicine 2023, 36: 2192855. PMID: 36958808, DOI: 10.1080/14767058.2023.2192855.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAnemiaAnemia, Iron-DeficiencyFemaleHumansInfant, NewbornIronPregnancyRetrospective StudiesConceptsIron deficiency anemiaMaternal morbidity compositeIntravenous ironMorbidity compositePotential confoundersElectronic medical recordsPregnant patientsTreatment courseDeficiency anemiaHigh-risk baseline characteristicsMultivariable logistic regression modellingRetrospective cohort studyFull treatment courseHospital electronic medical recordsIntensive care unitLogistic regression modellingGreater increaseMaternal morbidityMaternal outcomesNeonatal outcomesBaseline characteristicsCohort studyBlood transfusionPrimary outcomeTerm deliveryMaximum Dose Rate of Intrapartum Oxytocin Infusion and Associated Obstetric and Perinatal Outcomes
Son M, Roy A, Grobman W, Miller E, Dude A, Peaceman A, Stetson B. Maximum Dose Rate of Intrapartum Oxytocin Infusion and Associated Obstetric and Perinatal Outcomes. Obstetrics And Gynecology 2023, 141: 379-386. PMID: 36649339, DOI: 10.1097/aog.0000000000005058.Peer-Reviewed Original ResearchMeSH KeywordsCesarean SectionDelivery, ObstetricDouble-Blind MethodFemaleHumansInfant, NewbornLabor, InducedOxytocicsOxytocinPregnancyConceptsTitration regimenCesarean deliveryVaginal deliveryMultivariable analysisAdverse outcomesNeonatal intensive care unit admissionComposite severe neonatal morbidityIntensive care unit admissionSecondary analysisCumulative proportionPerinatal adverse outcomesCare unit admissionSevere neonatal morbiditySpontaneous vaginal deliveryMagnesium sulfate infusionUnderwent cesarean deliveryRupture of membranesWeeks of gestationNICU admissionUnit admissionHypertensive disordersLack of evidenceNeonatal morbidityNulliparous patientsPerinatal outcomes
2022
Changes in preterm birth during the COVID-19 pandemic by duration of exposure and race and ethnicity
Mullin AM, Handley SC, Lundsberg L, Elovitz MA, Lorch SA, McComb EJ, Montoya-Williams D, Yang N, Dysart K, Son M, Greenspan J, Culhane JF, Burris HH. Changes in preterm birth during the COVID-19 pandemic by duration of exposure and race and ethnicity. Journal Of Perinatology 2022, 42: 1346-1352. PMID: 35974082, PMCID: PMC9379882, DOI: 10.1038/s41372-022-01488-1.Peer-Reviewed Original ResearchMeSH KeywordsCOVID-19EthnicityFemaleHumansInfant, NewbornPandemicsPregnancyPremature BirthRisk FactorsConceptsBlack-White disparitiesDuration of exposureOverall PTBPTB phenotypesPreterm birthWhite patientsStudy designWeHigh riskLower riskPandemic exposureNew HavenRacial disparitiesPatientsPrior yearCOVID-19 pandemicWeeksExposure durationExposureBirthRiskPandemicDurationDisparitiesPTBPandemic effectsOutpatient penicillin allergy evaluation during pregnancy and associated clinical outcomes
Kwah JH, Burn MS, Liao J, Cate J, Son M. Outpatient penicillin allergy evaluation during pregnancy and associated clinical outcomes. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100674. PMID: 35691578, DOI: 10.1016/j.ajogmf.2022.100674.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsDrug HypersensitivityFemaleHumansInfant, NewbornOutpatientsPenicillinsPregnancyRetrospective StudiesConceptsPenicillin allergy evaluationPenicillin allergyPregnant womenAllergy evaluationHospital stayNeonatal outcomesClinical benefitIntensive care unit admissionBirth hospitalization lengthUnverified penicillin allergyCare unit admissionNeonatal adverse outcomesRetrospective cohort studyMedical record reviewPostpartum hospital stayAdditional clinical benefitLarge academic hospitalElectronic medical recordsBeta-lactam antibioticsPostpartum infectionReferred womenUnit admissionMaternal outcomesCohort studyTrue allergyIntrapartum nipple stimulation therapy for labor induction: a randomized controlled external pilot study of acceptability and feasibility
Stark EL, Athens ZG, Son M. Intrapartum nipple stimulation therapy for labor induction: a randomized controlled external pilot study of acceptability and feasibility. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100575. PMID: 35042047, DOI: 10.1016/j.ajogmf.2022.100575.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentFeasibility StudiesFemaleHumansInfant, NewbornLabor, InducedMaleNipplesOxytocicsOxytocinPilot ProjectsPregnancyConceptsObstetrical care providersExternal pilot studyLabor inductionStimulation therapyOxytocin infusionNipple stimulationPain levelsCare providersPilot studyInitiation of oxytocinPrimary outcome measureElectric breast pumpWeeks of gestationNeonatal intensive careParticipants' pain levelsNon-English speakingEligible womenMedian durationIntervention startMedian timeIntensive careMinutes of stimulationBreast pumpLabor progressOutcome measures
2021
Birth Hospital Length of Stay and Rehospitalization During COVID-19
Handley SC, Gallagher K, Breden A, Lindgren E, Lo JY, Son M, Murosko D, Dysart K, Lorch SA, Greenspan J, Culhane JF, Burris HH. Birth Hospital Length of Stay and Rehospitalization During COVID-19. Pediatrics 2021, 149: e2021053498. PMID: 34889449, PMCID: PMC9645693, DOI: 10.1542/peds.2021-053498.Peer-Reviewed Original ResearchConceptsInfant rehospitalizationAdjusted odds ratioTerm infantsBirth hospitalization dischargeBirth hospitalization lengthHealthy term infantsRetrospective cohort studyCoronavirus disease 2019 eraDay of birthCOVID-19Hospitalization dischargePrepandemic eraHospital lengthMultivariable adjustmentCohort studyHospitalization lengthShorter LOSAdjusted analysisOdds ratioRehospitalizationInfantsHealth systemAdditional outcomesCOVID-19 eraMixed effects modelsDuration of Exposure to General Endotracheal Anesthesia during Cesarean Deliveries at Term and Perinatal Complications
Swanson K, Liang L, Grobman WA, Higgins N, Roy A, Son M. Duration of Exposure to General Endotracheal Anesthesia during Cesarean Deliveries at Term and Perinatal Complications. American Journal Of Perinatology 2021, 39: 232-237. PMID: 34844279, DOI: 10.1055/s-0041-1739355.Peer-Reviewed Original ResearchConceptsGeneral endotracheal anesthesiaPrimary perinatal outcomeCesarean deliveryPerinatal complicationsPerinatal outcomesDuration of exposureMaternal morbidityMultivariable analysisGeneral anesthesiaEndotracheal anesthesiaFetal statusSingle tertiary care centerComposite of complicationsPrior abdominal surgeryTertiary care centerWeeks of gestationMaternal complicationsNonanomalous gestationsApgar scoreMultivariable adjustmentSecondary outcomesAbdominal surgeryBivariable analysisRetrospective studyCare centerCoronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population
Son M, Gallagher K, Lo JY, Lindgren E, Burris HH, Dysart K, Greenspan J, Culhane JF, Handley SC. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population. Obstetrics And Gynecology 2021, 138: 542-551. PMID: 34433180, PMCID: PMC8454282, DOI: 10.1097/aog.0000000000004547.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionAdverse pregnancy-related outcomesPregnancy-related outcomesCoronavirus disease 2019 (COVID-19) pandemicDisease 2019 pandemicPregnancy outcomesGestational ageSARS-CoV-2 testingDiverse U.S. cohortAdverse pregnancy outcomesRetrospective cohort studyPositive test resultsSARS-CoV-2 diagnosisSignificant differencesNegative test resultsHypertensive disordersPlacental abruptionBaseline characteristicsCohort studyPreterm birthPostpartum hemorrhagePregnant womenCesarean birthU.S. cohortPublic insurancePatient characteristics associated with complications of external cephalic version
Dahl CM, Zhang Y, Ong JX, Yeh C, Son M, Miller ES, Roy A, Grobman WA. Patient characteristics associated with complications of external cephalic version. American Journal Of Obstetrics & Gynecology MFM 2021, 3: 100411. PMID: 34058425, DOI: 10.1016/j.ajogmf.2021.100411.Peer-Reviewed Original ResearchConceptsExternal cephalic versionBody mass indexPatient characteristicsCephalic versionPlacental locationGestational ageFetal weightMass indexCord prolapsePlacental abruptionFetal statusSpontaneous ruptureIntensive care unit admissionSingle quaternary care centerHigher body mass indexExternal cephalic version attemptAnterior placental locationNonreassuring fetal statusUmbilical cord prolapseCare unit admissionCord arterial pHGreater gestational ageMultivariable logistic regressionQuaternary care centerExternal cephalic version successHigh-Dose Compared With Standard-Dose Oxytocin Regimens to Augment Labor in Nulliparous Women
Son M, Roy A, Stetson BT, Grady NT, Vanecko MC, Bond N, Swanson K, Grobman WA, Miller ES, Peaceman AM. High-Dose Compared With Standard-Dose Oxytocin Regimens to Augment Labor in Nulliparous Women. Obstetrics And Gynecology 2021, 137: 991-998. PMID: 33957657, DOI: 10.1097/aog.0000000000004399.Peer-Reviewed Original ResearchConceptsHigh-dose groupHigh-dose oxytocin regimenStandard dosingAugmentation of laborUmbilical artery acidemiaLabor durationPrimary outcomeSecondary outcomesNulliparous womenCesarean birthNeonatal intensive care unit admissionIntensive care unit admissionApgar score 3Care unit admissionStandard-dose groupPrespecified secondary outcomesPrimary cesarean birthWeeks of gestationAugment laborClinical chorioamnionitisMorbidity compositeNulliparous participantsUnit admissionObstetric morbidityPerinatal outcomes
2014
Preterm Premature Rupture of Membranes and the Rate of Neonatal Sepsis After Two Courses of Antenatal Corticosteroids
Gyamfi-Bannerman C, Son M. Preterm Premature Rupture of Membranes and the Rate of Neonatal Sepsis After Two Courses of Antenatal Corticosteroids. Obstetrics And Gynecology 2014, 124: 999-1003. PMID: 25437730, DOI: 10.1097/aog.0000000000000460.Peer-Reviewed Original ResearchConceptsNeonatal sepsisPreterm premature ruptureCorticosteroid coursesPremature ruptureMaternal-fetal medicine unitRespiratory distress syndromeMultivariable logistic regressionStudent's t-testAntenatal corticosteroidsPreterm PROMSingleton gestationsCohort studyPatient characteristicsDistress syndromePrimary outcomeGestational agePrimary exposureBirth weightMedicine unitSepsisSecondary analysisLogistic regressionCategorical variablesT-testLength of time