2024
Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues
Huang D, Shen H, Xie F, Hu D, Jin Q, Hu Y, Zhong T. Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues. Journal Of Biological Engineering 2024, 18: 36. PMID: 38845032, PMCID: PMC11155050, DOI: 10.1186/s13036-024-00431-6.Peer-Reviewed Original ResearchMesenchymal stem cellsMSC-ExosTissue regenerationMesenchymal stem cell-derived exosomesStem cell-derived exosomesImmune effector cellsCell-derived exosomesIschemic heart diseaseMSC-derived exosomesEffector cellsLung injuryArticular cartilageTissue applicationsLiver fibrosisInflammatory diseasesImmune responseHeart diseaseAnti-inflammatory compoundsStem cellsIntercellular communicationClinical applicationDiseaseExosomesTissueLiverResearch progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases
Wang L, Fang X, Ling B, Wang F, Xia Y, Zhang W, Zhong T, Wang X. Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases. Frontiers In Cellular Neuroscience 2024, 18: 1359453. PMID: 38515787, PMCID: PMC10955106, DOI: 10.3389/fncel.2024.1359453.Peer-Reviewed Original ResearchNeurodegenerative diseasesHuntington's diseaseAlzheimer's diseaseAmyotrophic lateral sclerosisSignaling networksDisease-related researchTreatment of neurodegenerative diseasesCell deathPathogenic cascadeIron-dependentNeurodegenerative disordersBreakdown of cellsNeurodegenerative conditionsFerroptosisLateral sclerosisNeuronal lossParkinson's diseaseCellsHuntingtonTherapeutic approachesAlzheimerLipid peroxidationDiseaseMechanismLipid
2019
Engineering of human brain organoids with a functional vascular-like system
Cakir B, Xiang Y, Tanaka Y, Kural MH, Parent M, Kang YJ, Chapeton K, Patterson B, Yuan Y, He CS, Raredon MSB, Dengelegi J, Kim KY, Sun P, Zhong M, Lee S, Patra P, Hyder F, Niklason LE, Lee SH, Yoon YS, Park IH. Engineering of human brain organoids with a functional vascular-like system. Nature Methods 2019, 16: 1169-1175. PMID: 31591580, PMCID: PMC6918722, DOI: 10.1038/s41592-019-0586-5.Peer-Reviewed Original ResearchConceptsHuman cortical organoidsBlood-brain barrier characteristicsTrans-endothelial electrical resistanceVasculature-like structuresHuman brain organoidsHuman brain developmentCortical organoidsFunctional maturationPrenatal brainBrain diseasesBrain developmentHuman embryonic stem cellsBlood vesselsBrain organoidsTight junctionsDiseaseStem cellsOrganoidsVariant 2Nutrient transportersNutrient deliveryCellsEndotheliumMicrovasculaturehESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids
Xiang Y, Tanaka Y, Cakir B, Patterson B, Kim KY, Sun P, Kang YJ, Zhong M, Liu X, Patra P, Lee SH, Weissman SM, Park IH. hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids. Cell Stem Cell 2019, 24: 487-497.e7. PMID: 30799279, PMCID: PMC6853597, DOI: 10.1016/j.stem.2018.12.015.Peer-Reviewed Original ResearchConceptsReciprocal projectionsThree-dimensional organoid modelsForebrain disorderHuman brain developmentCortical organoidsHuman thalamusPeripheral tissuesThalamusRelated disordersThalamic developmentSingle-cell RNA sequencingBrain developmentHuman embryonic stem cellsCircuit organizationCortexOrganoid modelsRegion-specific organoidsTelencephalic fateStem cellsOrganoid techniquesOrganoidsDisordersRNA sequencingRelay hubDisease