Featured Publications
Development of “Hunger Neurons” and the Unanticipated Relationship Between Energy Metabolism and Mother-Infant Interactions
Iyilikci O, Zimmer MR, Dietrich MO. Development of “Hunger Neurons” and the Unanticipated Relationship Between Energy Metabolism and Mother-Infant Interactions. Biological Psychiatry 2022, 91: 907-914. PMID: 35397878, PMCID: PMC10184517, DOI: 10.1016/j.biopsych.2022.02.962.Peer-Reviewed Original Research
2012
Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons
Dietrich MO, Horvath TL. Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nature Reviews Drug Discovery 2012, 11: 675-691. PMID: 22858652, DOI: 10.1038/nrd3739.Peer-Reviewed Original ResearchConceptsNPY/AgRP neuronsNegative energy balanceSevere side effectsAgRP neuronsPOMC neuronsPositive energy balanceChronic disordersPeripheral tissuesReactive oxygen speciesSide effectsLong-term positive energy balanceCalorie restrictionAnti-obesity drug developmentBehavioral interventionsIntense behavioral interventionsPro-opiomelanocortin (POMC) neuronsChronic metabolic disorderLong-term treatmentWhite adipose tissueAlternative therapeutic approachAnti-obesity therapiesPromotion of satietyNew drug therapiesPopulations of neuronsHigher brain functions