2023
Chronic diastolic stretch unmasks conduction defects in an in vitro model of arrhythmogenic cardiomyopathy
Ng R, Gokhan I, Stankey P, Akar F, Campbell S. Chronic diastolic stretch unmasks conduction defects in an in vitro model of arrhythmogenic cardiomyopathy. AJP Heart And Circulatory Physiology 2023, 325: h1373-h1385. PMID: 37830983, PMCID: PMC10977872, DOI: 10.1152/ajpheart.00709.2022.Peer-Reviewed Original ResearchArrhythmogenic cardiomyopathyDiastolic stretchConduction deficitsConduction velocityIntensity of exerciseAction potential parametersDifferent time pointsDisease progressionHigh afterloadContractile functionHemodynamic parametersProgressive disorderUnderlying pathomechanismsArrhythmia vulnerabilityConduction defectsPhysiological shorteningHeart tissueConnexin 43Time pointsERK signalingCardiomyopathyLysosome activityCardiac cycleDesmosomal proteinsExercise
2008
Electrophysiological remodeling in Dilated Cardiomyopathy and Heart Failure
Akar F, Tomaselli G. Electrophysiological remodeling in Dilated Cardiomyopathy and Heart Failure. 2008, 290-304. DOI: 10.1007/978-1-84628-854-8_19.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHeart failureCardiac remodelingComplete heart blockStructural heart diseaseAtrial fibrillationHeart blockMyocardial infarctionVentricular pacingElectrophysiological remodelingHeart diseaseMechanical dysfunctionHeart ratePersistent changesRemodelingActivation sequenceEntire organKey regulatory proteinsGene expressionExtracellular matrixInfarctionTachycardiaCardiomyopathyFailureDysfunctionFibrillation