2023
Chronic diastolic stretch unmasks conduction defects in an in vitro model of arrhythmogenic cardiomyopathy
Ng R, Gokhan I, Stankey P, Akar F, Campbell S. Chronic diastolic stretch unmasks conduction defects in an in vitro model of arrhythmogenic cardiomyopathy. AJP Heart And Circulatory Physiology 2023, 325: h1373-h1385. PMID: 37830983, PMCID: PMC10977872, DOI: 10.1152/ajpheart.00709.2022.Peer-Reviewed Original ResearchArrhythmogenic cardiomyopathyDiastolic stretchConduction deficitsConduction velocityIntensity of exerciseAction potential parametersDifferent time pointsDisease progressionHigh afterloadContractile functionHemodynamic parametersProgressive disorderUnderlying pathomechanismsArrhythmia vulnerabilityConduction defectsPhysiological shorteningHeart tissueConnexin 43Time pointsERK signalingCardiomyopathyLysosome activityCardiac cycleDesmosomal proteinsExercise
1998
Modulated Dispersion Explains Changes in Arrhythmia Vulnerability During Premature Stimulation of the Heart
Laurita K, Girouard S, Akar F, Rosenbaum D. Modulated Dispersion Explains Changes in Arrhythmia Vulnerability During Premature Stimulation of the Heart. Circulation 1998, 98: 2774-2780. PMID: 9851966, DOI: 10.1161/01.cir.98.24.2774.Peer-Reviewed Original ResearchConceptsVentricular fibrillation thresholdSingle premature stimulusPremature stimuliArrhythmia vulnerabilityBaseline levelsPremature stimulationS1S2 intervalRepolarization gradientsGuinea pig heartsBaseline pacingFibrillation thresholdArrhythmogenic substrateVentricular fibrillationVentricular sitesStimulus-induced changesVentricular repolarizationCoupling intervalCardiac arrhythmiasS2 beatElectrophysiological propertiesAction potentialsOptical action potentialsHeterogeneous electrophysiological propertiesPig heartsRepolarization