Minhua Wang, PhD, MD, MS, MBBS
Assistant Professor of PathologyCards
About
Research
Publications
2026
Application of The International System for Serous Fluid Cytopathology to cerebrospinal fluid and adjunct flow cytometry analysis improves diagnostic accuracy
Wang M, Cai G. Application of The International System for Serous Fluid Cytopathology to cerebrospinal fluid and adjunct flow cytometry analysis improves diagnostic accuracy. Cancer Cytopathology 2026, 134: e70122. PMID: 42283197, DOI: 10.1002/cncy.70122.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidSerous Fluid CytopathologyDiagnostic accuracyRetrospective reviewHistory of hematologic malignancyFlow cytometryCalculated risk of malignancyRisk of malignancyCerebrospinal fluid cytologyCerebrospinal fluid diagnosisDiagnostic performance metricsPredicting risk stratificationCSF cytologyFlow cytometry resultsFlow cytometry analysisLeptomeningeal involvementCytological diagnosisCytomorphologic findingsHematologic malignanciesIndeterminate diagnosisCSF specimensRisk stratificationStudy cohortDiagnostic performanceMalignancyQuantitative pathology biomarkers for platinum resistance in ovarian cancer.
Sritharan D, Chadha S, Breuer G, Perera N, Fu D, Srinivasan A, Gupta A, Santin A, Ratner E, Wang M, Papatla K, Aneja S. Quantitative pathology biomarkers for platinum resistance in ovarian cancer. Journal Of Clinical Oncology 2026, 44: 5520-5520. DOI: 10.1200/jco.2026.44.16_suppl.5520.Peer-Reviewed Original ResearchPlatinum-resistant ovarian cancerOvarian cancerPlatinum resistancePlatinum-sensitiveClinical predictorsValidation cohortPredictor of platinum resistanceHigh-grade serous ovarian cancerFirst-line systemic treatmentEarly identification of patientsPlatinum-based chemotherapyPrimary ovarian cancerSerous ovarian cancerEarly identificationPathological biomarkersIdentification of patientsIndividual risk profileTwo-tailed t-testCA-125Residual diseaseChi-square testSystemic treatmentTreatment escalationClinical characteristicsPrognostic utilityClaudin 18.2 Expression Concordance in Paired Cytology and Surgical Specimens of Gastric and Gastroesophageal Junction Adenocarcinomas.
Yang R, Kaur H, Wang M, Wang X, Zhang X, Cai G. Claudin 18.2 Expression Concordance in Paired Cytology and Surgical Specimens of Gastric and Gastroesophageal Junction Adenocarcinomas. Archives Of Pathology & Laboratory Medicine 2026 PMID: 42019964, DOI: 10.5858/arpa.2025-0466-oa.Peer-Reviewed Original ResearchGastroesophageal junction adenocarcinomaSurgical specimensPaired cytologyJunction adenocarcinomaCLDN18.2 expressionCytology specimensPredictive valueGastric primary tumorNegative predictive valuePositive predictive valueClinically actionable targetsMetastatic sitesPrimary tumorClinicopathological variablesCytology casesPatient selectionCLDN18.2Diagnostic performanceSubgroup analysisBiomarker testingCytologyImmunohistochemistry assayAdenocarcinomaGastroesophagealSpecimen origin
2025
Prognostic significance of pelvic washing cytology in early stage endometrial cancer: A 10‐year matched cohort analysis from a large single institute
Wang M, Abi‐Raad R, Adeniran A, Krishnamurti U, Buza N, Hui P, Cai G, Sun T. Prognostic significance of pelvic washing cytology in early stage endometrial cancer: A 10‐year matched cohort analysis from a large single institute. Cancer Cytopathology 2025, 133: e70057. PMID: 41159755, DOI: 10.1002/cncy.70057.Peer-Reviewed Original ResearchConceptsEarly stage endometrial cancerPW cytologyStage endometrial cancerPelvic washingsAccurate risk stratificationEndometrial cancerPrognostic significancePrognostic impactIndependent predictorsInternational Federation of Gynecology and Obstetrics (FIGO) criteriaStage I/II endometrial cancerAccurate risk stratification of patientsIndependent adverse prognostic factorAssociated with significantly worse disease-free survivalRisk stratification of patientsPelvic washing cytologyRetrospective case-control cohortsMultivariate logistic regression analysisEndometrial cancer stagingAdverse prognostic factorDisease-free survivalInternational FederationTumor histologic subtypeII endometrial cancerEarly stage diseaseAmerican College of Radiology–Developed Thyroid Imaging Reporting and Data System 3, 4, and 5 thyroid nodules are distinctive by cytology, genetic imprints, and histology
Yu S, Wang M, Langdon J, Zhao J, Pai S, Sinard J, Cai G, Prasad M, Adeniran A. American College of Radiology–Developed Thyroid Imaging Reporting and Data System 3, 4, and 5 thyroid nodules are distinctive by cytology, genetic imprints, and histology. Cancer Cytopathology 2025, 133: e70050. PMID: 41021263, DOI: 10.1002/cncy.70050.Peer-Reviewed Original ResearchConceptsTI-RADS 3Papillary thyroid carcinomaTI-RADS 5TI-RADS 4Risk of malignancyThyroid Imaging ReportingTI-RADSResected nodulesThyroid nodulesImaging ReportingLow risk of malignancyAmerican CollegeLow riskAssociated with high mortalitySuspicious thyroid nodulesHigh-risk mutationsFine-needle aspirationLow malignancy riskHigh-resolution ultrasoundMalignancy rateMalignancy riskThyroid carcinomaHistological featuresClinical dataMolecular testingFumarate Hydratase-deficient Uterine Smooth Muscle Tumors: A 6-Year Prospective Analysis of Morphology-based Screening and Patient Outcomes
Sun T, Niu N, Healy C, Abdelal H, Wang M, Hui P, Buza N. Fumarate Hydratase-deficient Uterine Smooth Muscle Tumors: A 6-Year Prospective Analysis of Morphology-based Screening and Patient Outcomes. International Journal Of Gynecological Pathology 2025, 45: 189-199. PMID: 40991420, DOI: 10.1097/pgp.0000000000001134.Peer-Reviewed Original ResearchUterine smooth muscle tumorsSmooth muscle tumorsFH deficiencyRenal cell carcinomaMuscle tumorsUterine leiomyomaCell carcinomaFumarate hydratasePathogenic variantsEarly-onset uterine leiomyomasGenetic counselingPapillary renal cell carcinomaProspective analysisFH-deficient leiomyomasGermline fumarate hydrataseSeventy-one tumorsAbnormal vaginal bleedingMedian patient ageHereditary cancer-related genesGermline pathogenic mutationsAutosomal dominant disorderFH-deficient tumorsCancer-related genesFH immunohistochemistryPelvic painSelection of neuroendocrine markers in diagnostic workup of neuroendocrine neoplasms: The real‐world data and machine learning model algorithms
Tang H, Xia H, Sun N, Hernandez P, Wang M, Adeniran A, Cai G. Selection of neuroendocrine markers in diagnostic workup of neuroendocrine neoplasms: The real‐world data and machine learning model algorithms. Cancer Cytopathology 2025, 133: e70018. PMID: 40289395, DOI: 10.1002/cncy.70018.Peer-Reviewed Original ResearchConceptsMachine learning algorithmsReal-world dataLearning algorithmsNeural networkRandom forestNeural network modelNeuroendocrine neoplasmsAUC-ROCMachine learning modelsNeuroendocrine markersDiagnostic workupLearning modelsMachine learning modeling algorithmsNetwork modelDiagnosis of neuroendocrine neoplasmsModeling algorithmAlgorithmArea under the curveMachineArea under the curve of receiver operating characteristic curvesReceiver operating characteristic curveNetworkNEC casesCytology casesNon-NENsThe role of frozen section in gynecologic pathology
Kaur H, Wang M. The role of frozen section in gynecologic pathology. Seminars In Diagnostic Pathology 2025, 42: 150913. PMID: 40315682, DOI: 10.1016/j.semdp.2025.150913.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTumor sizeHistological typeFrozen sectionsSex cord stromal tumorsCervical stromal involvementExtensive surgical stagingGross tumor sizeOvarian surface involvementUterine mesenchymal tumorsPrimary ovarian tumorsUterine endometrial carcinomaGerm cell tumorsOvarian epithelial tumorsLymph node statusPresence of malignancyLocal tumor invasionSurgery aidsStromal involvementMyometrial involvementSurgical stagingMyometrial invasionOvarian tumorsStromal tumorsNode statusDistant spread
2024
TRPS1 expression in cytologic specimens of salivary duct carcinoma and other salivary gland tumors
Wang M, Cai G, Gilani S. TRPS1 expression in cytologic specimens of salivary duct carcinoma and other salivary gland tumors. Annals Of Diagnostic Pathology 2024, 74: 152406. PMID: 39547127, DOI: 10.1016/j.anndiagpath.2024.152406.Peer-Reviewed Original ResearchConceptsTRPS1 expressionSalivary duct carcinomaTrichorhinophalangeal syndrome type 1Salivary gland tumorsBreast carcinomaMucoepidermoid carcinomaSecretory carcinomaWarthin's tumorDuct carcinomaGland tumorsSalivary duct carcinoma casesCase of secretory carcinomaAcinic cell carcinomaAdenoid cystic carcinomaBasal cell adenomaImmunophenotypic featuresCystic carcinomaSurgical specimensCell adenomaCell carcinomaCytology casesCytology specimensPleomorphic adenomaCell blocksBreast cancerThe World Health Organization System for Reporting Pancreaticobiliary Cytopathology: Standardized Categories and Practical Approaches to Pancreatic Lesions
Wang M, Lozano M, Cai G. The World Health Organization System for Reporting Pancreaticobiliary Cytopathology: Standardized Categories and Practical Approaches to Pancreatic Lesions. Journal Of Clinical And Translational Pathology 2024, 4: 122-135. PMID: 40191142, PMCID: PMC11969574, DOI: 10.14218/jctp.2024.00034.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
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Overview
Minhua Wang, MD, PhD, is a pathologist with a clinical focus on cytopathology and gynecological pathology. Much of her clinical work involves studying specimens with a microscope and reviewing ancillary tests. As a cytopathologist, she studies fluid, smear, and aspiration specimens to make a diagnosis. In the gynecological pathology service, she examines surgical tissue samples from the female reproductive tract to look for the presence of malignancy.
Dr. Wang says she was drawn to pathology because she saw it as an important link in patient care. “The pathological diagnosis provides clinicians with crucial information in their decision-making regarding disease management,” she says. She plays a key role in rendering definitive cancer diagnoses and describes it as “a privilege” to assist clinicians in the care of cancer patients.
In addition to her clinical work as a pathologist, Dr. Wang is engaged in research projects to investigate certain biomarkers and their utility in enhancing diagnostic accuracy for certain types of cancers and/or their prognostic value using cytology specimens. She also is involved in other cytohistological validation studies that aim to improve pathological diagnostic accuracy to better guide clinical decision-making.
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789 Howard Avenue, Ste CB 506D
New Haven, CT 06519