Hee-Hoon Kim, PhD
Postdoctoral Associate in PathologyAbout
Research
Publications
2026
Glutamate excreted by LepR⁺ BM-MSCs mitigates alcohol-associated liver disease by promoting IL-1R2⁺ monocyte migration
Shim Y, Kim H, Kim M, Lee J, Kim K, Choi S, Chung K, Lee E, Lee K, Byun J, Oh J, Han J, Byun J, Park J, Kim W, Lee Y, Jeong W. Glutamate excreted by LepR⁺ BM-MSCs mitigates alcohol-associated liver disease by promoting IL-1R2⁺ monocyte migration. Clinical And Molecular Hepatology 2026 PMID: 42315151, DOI: 10.3350/cmh.2026.0425.Peer-Reviewed Original ResearchAlcohol-related liver diseaseBM-MSCsIL-1R2Natural killerIFN-gKnockout miceLiver diseaseAlcohol-related liver disease patientsBM NK cellsMGluR5 knockout miceAlcohol-associated liver diseaseMetabotropic glutamate receptor 5Monocyte migrationNK cell recruitmentWild-type miceGlutamate receptor 5Interleukin-1 receptor 2Anti-inflammatory monocytesEthanol-fed miceAlcohol-metabolizing enzymesBone marrow mesenchymal stromal cellsExacerbated liver injuryLiver tissueMarrow mesenchymal stromal cellsIL-1b levelsExoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging
Mishra M, Kim H, Youm Y, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw A, Scherer P, Artyomov M, Dixit V. Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging. Nature Aging 2026, 6: 1064-1078. PMID: 41974968, PMCID: PMC13190345, DOI: 10.1038/s43587-026-01107-0.Peer-Reviewed Original ResearchExtracellular signal-regulated kinaseCaloric restrictionComplement pathwayPhospholipase A2 group VIIAge-related inflammationSignal-regulated kinaseCALERIE trialFibroblast growth factor 21Macrophage subsetsVisceral fatReduce inflammagingAutocrine signalingC3a/C3 ratioPlasma samplesMiceInflammagingInflammationEffects of CRAgeGroup VIIC3aComplementHuman agingDiverse organismsPathwayImmunometabolic resistors of aging in long-lived golden spiny mice
Kim H, Sagiv-Zangi T, Youm Y, Vardi-Naim H, Dlugos T, Strino F, Kazavchinsky-Bar M, Egulsky L, Bodogai M, Biragyn A, Kluger Y, Kronfeld-Schor N, Dixit V. Immunometabolic resistors of aging in long-lived golden spiny mice. Science Advances 2026, 12: eaec9991. PMID: 41739938, PMCID: PMC12935055, DOI: 10.1126/sciadv.aec9991.Peer-Reviewed Original Research
2025
Metabolic regulation of immunological aging
Kim H, Dixit V. Metabolic regulation of immunological aging. Nature Aging 2025, 5: 1425-1440. PMID: 40813811, DOI: 10.1038/s43587-025-00921-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsImmune cellsLoss of naive T cellsT-cell receptor repertoire diversityImmune systemNaive T cellsAge-related thymic involutionInnate immune cellsImmunometabolic mechanismsT cellsImmunological agingThymic involutionRepertoire diversityChronic inflammationGeneration of metabolitesDietary interventionReproductive ageOrganismal metabolismAltered metabolismDisease susceptibilityMolecular perturbationsFunctional declineMetabolic mechanismsMetabolic systemsBiological activityAgeBinge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells
Yang K, Kim K, Ryu T, Shim Y, Kim H, Choi S, Kim M, Chung K, Lee E, Lee K, Jeon J, Kim P, Kim Y, Ku T, Jeong H, Nam K, Lim G, Choi D, Kim S, Eun H, Kim W, Jeong W. Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells. Nature Communications 2025, 16: 5546. PMID: 40595616, PMCID: PMC12216207, DOI: 10.1038/s41467-025-60820-3.Peer-Reviewed Original ResearchConceptsVesicular glutamate transporter 3Alcohol-related steatohepatitisKupffer cellsIntracellular Ca2+ levelsMetabotropic glutamate receptor 5Chronic alcohol intakeBinge drinkingImmune cell activationGlutamate receptor 5Analysis of patient samplesCa2+ levelsHepatic amino acid metabolismNADPH oxidase 2Plasma glutamate concentrationExocytosis of glutamateAlcohol intakeReceptor 5Male miceAryl hydrocarbon receptorAmino acid metabolismHepatic inflammationCell activationPerivenous hepatocytesGlutamate secretionPatient samplesHormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.
Guan C, Ryu S, Dong M, Youm YH, Mohanty S, Maeda R, Orliaguet L, Kim HH, Dlugos T, Smith SR, Ravussin E, Onyuru J, Wang A, Shaw AC, Hoffman HM, Kluger Y, Sugiura Y, Dixit VD. Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome. BioRxiv 2025 PMID: 40501605, DOI: 10.1101/2025.05.27.656381.Publications for non-academic audiences
2024
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity
Kim H, Dixit V. Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity. Cell Metabolism 2024, 36: 1911-1913. PMID: 39232279, DOI: 10.1016/j.cmet.2024.08.003.Peer-Reviewed Original ResearchCX3CR1+ macrophages interact with hepatic stellate cells to promote hepatocellular carcinoma through CD8+ T cell suppression.
Jeong JM, Choi SE, Shim YR, Kim HH, Lee YS, Yang K, Kim K, Kim MJ, Chung KPS, Kim SH, Byun JS, Eun HS, Jeong WI. CX3CR1+ macrophages interact with hepatic stellate cells to promote hepatocellular carcinoma through CD8+ T cell suppression. Hepatology 2024 PMID: 39028913, DOI: 10.1097/HEP.0000000000001021.Peer-Reviewed Original ResearchCX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression
Jeong J, Choi S, Shim Y, Kim H, Lee Y, Yang K, Kim K, Kim M, Chung K, Kim S, Byun J, Eun H, Jeong W. CX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression. Hepatology 2024, 82: 655-668. PMID: 40833997, PMCID: PMC12356560, DOI: 10.1097/hep.0000000000001021.Peer-Reviewed Original ResearchConceptsCD8+ T cellsArginase-1 expressionIn vitro cocultureArginase-1Peritumoral areaMyeloid cellsImmunoregulatory functionsCD8+ T cell suppressionCD8+ T cell proliferationPharmacological inhibitionColocalized expressionGenetic deficiencyHuman LX-2 cellsT cell suppressionTumor-bearing miceT cell proliferationCD14+ cellsCX3CL1 mRNA expressionSubpopulation of macrophagesDirect treatmentExpression of CX3CL1Function of HSCsHepatic stellate cellsAdoptive transferFlow cytometry analysis
2023
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
Kim H, Shim Y, Kim H, Yang K, Ryu T, Kim K, Choi S, Kim M, Woo C, Chung K, Hong S, Shin H, Suh J, Jung Y, Hwang G, Kim W, Kim S, Eun H, Seong J, Jeong W. xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity. Cell Reports 2023, 42: 112636. PMID: 37310859, DOI: 10.1016/j.celrep.2023.112636.Peer-Reviewed Original ResearchConceptsIFN-g productionObesity-related metabolic disordersNK cellsIFN-gNatural killer (NK) cellsMetabolic disordersMetabotropic glutamate receptor 5NK cell recruitmentNatural killer cellsInterferon-g productionC-X-C motif chemokine ligandGlutamate receptor 5Effect of obesityC-X-CMotif chemokine ligandKiller cellsGlutamate excretionBidirectional pathwaysCXCL12/CXCR4 axisWhite adipose tissueCXCL12 expressionReceptor 5Cell recruitmentInflammatory activityChemokine ligand
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Pathology
310 Cedar Street, LH 212
New Haven, Connecticut 06510
United States
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310 Cedar Street, Fl 3rd, Rm 316A
New Haven, CT 06510