2017
INPP5E Preserves Genomic Stability through Regulation of Mitosis
Potchanant E, Cerabona D, Sater Z, He Y, Sun Z, Gehlhausen J, Nalepa G. INPP5E Preserves Genomic Stability through Regulation of Mitosis. Molecular And Cellular Biology 2017, 37: e00500-16. PMID: 28031327, PMCID: PMC5335510, DOI: 10.1128/mcb.00500-16.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CycleCell NucleusFibroblastsGene Knockdown TechniquesGenomic InstabilityHeLa CellsHomeostasisHumansInterphaseM Phase Cell Cycle CheckpointsMiceMitosisModels, BiologicalPhosphatidylinositol 4,5-DiphosphatePhosphoric Monoester HydrolasesProtein TransportSubcellular FractionsSubstrate SpecificityConceptsCell cycle regulatory roleMaintenance of chromosome integrityPreserving genome stabilityInositol polyphosphate-5-phosphataseRegulating cell divisionRegulation of mitosisPrevention of aneuploidySpindle assembly checkpointEarly mitosisMORM syndromesMitotic exitGenome stabilityPhosphoinositide phosphataseMitotic entryChromosomal integrationCellular homeostasisINPP5ECell divisionPrimary ciliaCell cycleAssembly checkpointCellular metabolismSpindle functionGenetic knockoutRegulatory role
2013
The tumor suppressor CDKN3 controls mitosis
Nalepa G, Barnholtz-Sloan J, Enzor R, Dey D, He Y, Gehlhausen J, Lehmann A, Park S, Yang Y, Yang X, Chen S, Guan X, Chen Y, Renbarger J, Yang F, Parada L, Clapp W. The tumor suppressor CDKN3 controls mitosis. Journal Of Cell Biology 2013, 201: 997-1012. PMID: 23775190, PMCID: PMC3691455, DOI: 10.1083/jcb.201205125.Peer-Reviewed Original ResearchConceptsLibrary of small interfering RNAsLocalizes to mitotic centrosomesGenome-wide setNetwork of kinasesSignaling axisMass spectrometry screeningSmall interfering RNAEarly mitosisMitotic exitSubcellular localizationHuman phosphatasesSpindle checkpointMitotic centrosomesSerine 209Normal mitosisCell cycleG1/S transitionCDKN3MitosisTargeted anticancer therapeuticsDown-regulationCdc2CentrosomeAnticancer therapeuticsPhosphatase