2021
Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity
Lucas C, Vogels CBF, Yildirim I, Rothman JE, Lu P, Monteiro V, Gehlhausen JR, Campbell M, Silva J, Tabachnikova A, Peña-Hernandez MA, Muenker MC, Breban MI, Fauver JR, Mohanty S, Huang J, Shaw A, Ko A, Omer S, Grubaugh N, Iwasaki A. Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity. Nature 2021, 600: 523-529. PMID: 34634791, PMCID: PMC9348899, DOI: 10.1038/s41586-021-04085-y.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 variantsMRNA vaccine-induced immunityT-cell activation markersSARS-CoV-2 antibodiesSecond vaccine doseVaccine-induced immunityCell activation markersT cell responsesHigh antibody titresSARS-CoV-2Vaccine boosterVaccine doseActivation markersVaccine dosesHumoral immunityAntibody titresMRNA vaccinesVitro stimulationNeutralization capacityNeutralization responseCell responsesE484KNucleocapsid peptideAntibody-binding sitesGreater reduction
2020
Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein
Ko CJ, Harigopal M, Gehlhausen JR, Bosenberg M, McNiff JM, Damsky W. Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. Journal Of Cutaneous Pathology 2020, 48: 47-52. PMID: 32895985, DOI: 10.1111/cup.13866.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 spike proteinCOVID toesEccrine epitheliumEndothelial cellsSkin biopsiesSpike proteinReverse transcriptase polymerase chain reaction testingSARS-CoV-2 antibodiesPolymerase chain reaction testingSARS-CoV-2 RNAPotential pathogenetic mechanismsPositive immunohistochemical labelingSARS-CoV-2Endothelial depositionPathogenetic mechanismsImmunohistochemical stainingReaction testingImmunohistochemical labelingEccrine glandsRNA ISHImmunohistochemistrySpike RNAGold standardTissue sectionsBiopsyPerniosis during the COVID‐19 pandemic: Negative anti‐SARS‐CoV‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV‐2
Ko CJ, Harigopal M, Damsky W, Gehlhausen JR, Bosenberg M, Patrignelli R, McNiff JM. Perniosis during the COVID‐19 pandemic: Negative anti‐SARS‐CoV‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV‐2. Journal Of Cutaneous Pathology 2020, 47: 997-1002. PMID: 32745281, PMCID: PMC7436569, DOI: 10.1111/cup.13830.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 nucleocapsid proteinPerivascular lymphocytesImmunohistochemical stainingCOVID-19 pandemicSARS-CoV-2 immunohistochemistryNucleocapsid proteinSARS-CoV-2Inflammatory lesionsHistopathologic findingsIntravascular occlusionMicroscopic findingsPerniosisIntravascular materialLymphocytesLesionsPatientsStainingPandemicSuch casesCuffingHistopathologyCasesImmunohistochemistryFindingsProtein
2018
Early botryomycosis‐like plaques in the setting of Corynebacterium striatum septicemia
Gehlhausen J, Strausburg M, Gilbert K, Alomari A. Early botryomycosis‐like plaques in the setting of Corynebacterium striatum septicemia. International Journal Of Dermatology 2018, 58: 969-971. PMID: 30076602, DOI: 10.1111/ijd.14162.Peer-Reviewed Original Research
2016
Diffuse Dermal Angiomatosis of the Breast With an Apparent Etiology of Underlying Calcified Thrombosed Artery With Adjacent Fat Necrosis
Strausburg M, Gehlhausen J, Ludwig K, Warren S. Diffuse Dermal Angiomatosis of the Breast With an Apparent Etiology of Underlying Calcified Thrombosed Artery With Adjacent Fat Necrosis. American Journal Of Dermatopathology 2016, 38: 838-841. PMID: 27097335, DOI: 10.1097/dad.0000000000000581.Peer-Reviewed Original ResearchConceptsDiffuse dermal angiomatosisAssociated with various underlying conditionsCases of diffuse dermal angiomatosisLocal tissue ischemiaThrombosed arteryOral corticosteroidsApparent etiologyMass lesionFat necrosisUnderlying conditionTissue ischemiaHyperplastic vesselsVascular luminaSmoking cessationLower extremitiesBreastAngiomatosisArteryNecrosis