2018
Accurate estimation of cardiovascular risk in a non-diabetic adult: detecting and correcting the error in the reported Framingham Risk Score for the Systolic Blood Pressure Intervention Trial population
Warner F, Dhruva SS, Ross JS, Dey P, Murugiah K, Krumholz HM. Accurate estimation of cardiovascular risk in a non-diabetic adult: detecting and correcting the error in the reported Framingham Risk Score for the Systolic Blood Pressure Intervention Trial population. BMJ Open 2018, 8: e021685. PMID: 30037874, PMCID: PMC6059296, DOI: 10.1136/bmjopen-2018-021685.Peer-Reviewed Original ResearchConceptsSystolic Blood Pressure Intervention TrialFramingham risk scoreCardiovascular riskRisk scoreStudy populationStudy participantsNon-diabetic adultsTotal study populationHigh-risk populationClinical trial dataClinical trial sitesTrial populationIntervention trialsRisk populationsNew England JournalIndependent investigatorsTrial dataSecondary analysisSPRINT trialSPRINT dataTrialsRiskScoresParticipantsPopulation
2017
Association of Changing Hospital Readmission Rates With Mortality Rates After Hospital Discharge
Dharmarajan K, Wang Y, Lin Z, Normand ST, Ross JS, Horwitz LI, Desai NR, Suter LG, Drye EE, Bernheim SM, Krumholz HM. Association of Changing Hospital Readmission Rates With Mortality Rates After Hospital Discharge. JAMA 2017, 318: 270-278. PMID: 28719692, PMCID: PMC5817448, DOI: 10.1001/jama.2017.8444.Peer-Reviewed Original ResearchConceptsRisk-adjusted readmission ratesRisk-adjusted mortality ratesAcute myocardial infarctionHeart failureReadmission ratesMortality rateMyocardial infarctionMedicare feeService beneficiariesHospital readmission ratesMean hospitalHospital mortalityPostdischarge mortalityHospital dischargeHospital readmissionRetrospective studyAffordable Care ActReadmission reductionMAIN OUTCOMEPneumoniaHospitalSecondary analysisWeighted Pearson correlation coefficientMortalityCare Act
2008
Association of Early Follow-up After Acute Myocardial Infarction With Higher Rates of Medication Use
Daugherty SL, Ho PM, Spertus JA, Jones PG, Bach RG, Krumholz HM, Peterson ED, Rumsfeld JS, Masoudi FA. Association of Early Follow-up After Acute Myocardial Infarction With Higher Rates of Medication Use. JAMA Internal Medicine 2008, 168: 485-491. PMID: 18332293, DOI: 10.1001/archinte.168.5.485.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsAspirinContinuity of Patient CareEvidence-Based MedicineFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPoisson DistributionProportional Hazards ModelsProspective StudiesRegistriesRegression AnalysisTreatment OutcomeConceptsAcute myocardial infarctionMedication useMyocardial infarctionMultivariable analysisEarly outpatientEvidence-based medication useProspective Registry Evaluating OutcomesSecondary analysisEarly Follow-upBeta-blocker useUse of aspirinCurrent guideline recommendationsPrimary care physiciansEvidence-based therapiesHigh rateEligible patientsStatin useClinical characteristicsHospital dischargePrimary outcomeCare physiciansGuideline recommendationsMedication prescriptionsFollow-upEvaluating Outcomes
2005
Enrollment of Older Persons in Cancer Trials After the Medicare Reimbursement Policy Change
Gross CP, Wong N, Dubin JA, Mayne ST, Krumholz HM. Enrollment of Older Persons in Cancer Trials After the Medicare Reimbursement Policy Change. JAMA Internal Medicine 2005, 165: 1514-1520. PMID: 16009867, DOI: 10.1001/archinte.165.13.1514.Peer-Reviewed Original ResearchConceptsOlder patientsCancer trialsReimbursement policy changesOlder personsPatients' sociodemographic characteristicsTrial exclusion criteriaMultivariate logistic regressionProstate cancer trialsProportion of participantsNational Cancer InstituteRoutine care costsSignificant changesClinical trialsPrimary study sampleExclusion criteriaTrial participantsCancer InstitutePatientsPrimary analysisCare costsMultivariate analysisSecondary analysisSociodemographic characteristicsLogistic regressionCancer types
2004
National Patterns of Use and Effectiveness of Angiotensin-Converting Enzyme Inhibitors in Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction
Masoudi FA, Rathore SS, Wang Y, Havranek EP, Curtis JP, Foody JM, Krumholz HM. National Patterns of Use and Effectiveness of Angiotensin-Converting Enzyme Inhibitors in Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction. Circulation 2004, 110: 724-731. PMID: 15289383, DOI: 10.1161/01.cir.0000138934.28340.ed.Peer-Reviewed Original ResearchConceptsACE inhibitor prescriptionAngiotensin receptor blockersVentricular systolic dysfunctionHeart failureACE inhibitorsInhibitor prescriptionSystolic dysfunctionOlder patientsLeft ventricular systolic dysfunctionAngiotensin converting enzyme (ACE) inhibitorsSerum creatinine levelsACE inhibitor useCreatinine levelsHospital factorsInhibitor useReceptor blockersSerum creatininePatient genderClinical trialsTherapeutic substitutionLower riskEnzyme inhibitorsLower mortalityPatientsSecondary analysis
2000
What's Happening in Quality Improvement at the Local Hospital: A State Wide Study From the Cooperative Cardiovascular Project
Holmboe E, Meehan T, Radford M, Wang Y, Krumholz H. What's Happening in Quality Improvement at the Local Hospital: A State Wide Study From the Cooperative Cardiovascular Project. American Journal Of Medical Quality 2000, 15: 106-113. PMID: 10872260, DOI: 10.1177/106286060001500304.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCooperative Cardiovascular ProjectFull-time equivalentsAMI careNonfederal hospitalsIndividual hospitalsCare of patientsProcess of careMultidisciplinary QI teamQuality of careQuality improvement activitiesMyocardial infarctionLocal hospitalImprovement interventionsHospitalRegistered NursesSecondary analysisPhysician championsQI teamsCareScientific evidenceState-wide studyCritical pathwaysQuestionnaire studyDepartment