2008
Riluzole in the Treatment of Mood and Anxiety Disorders
Pittenger C, Coric V, Banasr M, Bloch M, Krystal JH, Sanacora G. Riluzole in the Treatment of Mood and Anxiety Disorders. CNS Drugs 2008, 22: 761-786. PMID: 18698875, DOI: 10.2165/00023210-200822090-00004.Peer-Reviewed Original ResearchConceptsTreatment of moodAnxiety disordersMultiple molecular actionsOpen-label trialPlacebo-controlled trialAmino acid neurotransmissionCommon adverse effectsLiver function testsAmyotrophic lateral sclerosisVoltage-gated sodium channelsBorderline personality disorderSelf-injurious behaviorStandard therapyIll patientsBipolar depressionFunction testsObsessive-compulsive disorderCase reportGlutamatergic neurotransmissionGlutamate levelsExtracellular glutamateClinical consequencesLateral sclerosisAstrocytic uptakeRiluzole
2005
Initial evidence of the beneficial effects of glutamate-modulating agents in the treatment of self-injurious behavior associated with borderline personality disorder.
Pittenger C, Krystal JH, Coric V. Initial evidence of the beneficial effects of glutamate-modulating agents in the treatment of self-injurious behavior associated with borderline personality disorder. The Journal Of Clinical Psychiatry 2005, 66: 1492-3. PMID: 16420092, DOI: 10.4088/jcp.v66n1121d.Peer-Reviewed Original ResearchConceptsGlutamate-modulating agentsBorderline personality disorderSelf-injurious behaviorBeneficial effectsPersonality disorderInitial evidence
1996
Recurrent self-injurious behavior in forensic patients
Hillbrand M, Young J, Krystal J. Recurrent self-injurious behavior in forensic patients. Psychiatric Quarterly 1996, 67: 33-45. PMID: 8623037, DOI: 10.1007/bf02244273.Peer-Reviewed Original ResearchConceptsSelf-injurious behaviorForensic patientsPsychiatric populationsSelf-injurious patientsGreat therapeutic challengeRecurrent self-injurious behaviorSelf-destructive patientsLonger hospitalizationTherapeutic challengeForensic psychiatric populationHigh prevalencePatientsVigorous interventionDiagnostic measuresPresent studyHospitalizationPopulationPrevalence