2007
Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation
Rinder CS, Smith MJ, Rinder HM, Cortright DN, Brodbeck RM, Krause JE, Smith BR. Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation. The Annals Of Thoracic Surgery 2007, 83: 146-152. PMID: 17184649, DOI: 10.1016/j.athoracsur.2006.08.019.Peer-Reviewed Original ResearchConceptsC5a receptor blockadeC5a receptor antagonistReceptor antagonistExtracorporeal circulationReceptor blockadeCD11b upregulationElastase releasePlatelet P-selectin expressionComplement C5a anaphylatoxinNeutrophil CD11b upregulationSimulated Extracorporeal CirculationFresh heparinized whole bloodNeutrophil elastase releasePlasma interleukin-8P-selectin expressionInterleukin-8 releaseConjugate formationHeparinized whole bloodCardiopulmonary bypassInflammatory responseLeukocyte adhesive receptorsExtracorporeal circuitInterleukin-8Neutrophil chemotaxisDownregulatory effectChapter 59 Cardiopulmonary bypass
Smith B, Rinder H, Rinder C. Chapter 59 Cardiopulmonary bypass. 2007, 1077-1095. DOI: 10.1016/b978-012369367-9/50821-1.Peer-Reviewed Original ResearchCardiopulmonary bypassHemostatic abnormalitiesMassive pulmonary embolismSevere respiratory failurePulmonary dysfunctionRenal dysfunctionRespiratory failureHemodynamic supportPulmonary embolismCardiac surgeryCardiac arrestEnvironmental hypothermiaMyocardial ischemiaPlatelet effectsClinical abnormalitiesCPB proceduresAbnormalitiesPhysiologic interactionsDysfunctionBypassPossible rolePrimary roleEmbolismComplicationsIschemia
2006
Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation
Rinder CS, Rinder HM, Smith MJ, Fitch JC, Tracey JB, Chandler WL, Rollins SA, Smith BR. Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation. Transfusion 2006, 46: 1130-1137. PMID: 16836559, DOI: 10.1111/j.1537-2995.2006.00861.x.Peer-Reviewed Original ResearchConceptsNeutrophil elastase releaseAnti-inflammatory activityAntithrombin IIICardiopulmonary bypassElastase releasePlatelet activationWhite blood cell activationDirect anti-inflammatory activitySystemic inflammatory reactionAbsence of endotheliumEndothelial effectsCardiac surgeryBlood cell activationAnticoagulant effectExtracorporeal circulationInflammatory reactionThrombin generationHigh doseClinical relevanceCell activationFibrin generationComplement activationThrombin activityStudy designCD11bTranscerebral Platelet Activation After Aortic Cross-Clamp Release is Linked to Neurocognitive Decline
Mathew JP, Rinder HM, Smith BR, Newman MF, Rinder CS. Transcerebral Platelet Activation After Aortic Cross-Clamp Release is Linked to Neurocognitive Decline. The Annals Of Thoracic Surgery 2006, 81: 1644-1649. PMID: 16631650, DOI: 10.1016/j.athoracsur.2005.12.070.Peer-Reviewed Original ResearchConceptsCross-clamp removalAortic cross-clamp removalCardiopulmonary bypassPlatelet activationNeurocognitive injuryCognitive deficitsNeurocognitive declineElective coronary artery bypass graft surgeryCoronary artery bypass graft surgeryAortic cross-clamp releaseArtery bypass graft surgeryBypass graft surgeryCross-clamp releaseSubset of patientsVenous blood samplesJugular venous blood samplesJugular venous bloodCPB patientsGraft surgeryCardiac surgeryPatient subsetsInjury scoreAortic archVenous bloodCognitive injury
2005
Atrial Fibrillation After Cardiac Surgery/Cardiopulmonary Bypass Is Associated with Monocyte Activation
Fontes ML, Mathew JP, Rinder HM, Zelterman D, Smith BR, Rinder CS. Atrial Fibrillation After Cardiac Surgery/Cardiopulmonary Bypass Is Associated with Monocyte Activation. Anesthesia & Analgesia 2005, 101: 17-23. PMID: 15976199, DOI: 10.1213/01.ane.0000155260.93406.29.Peer-Reviewed Original ResearchConceptsPostoperative atrial fibrillationC-reactive proteinPreoperative C-reactive proteinCardiopulmonary bypassAtrial fibrillationCardiac surgerySinus rhythmAortic cross-clamp releaseTroponin IPilot studyCross-clamp releaseSubset of patientsCardiac muscle damageNormal sinus rhythmLeukocyte inflammatory responsesExploratory pilot studyPMN CD11bCPB patientsInflammatory infiltrationPMN countCD11b upregulationCellular inflammationInflammatory responseMonocyte activationMuscle damage
2004
Effects of ε-Aminocaproic Acid and Aprotinin on Leukocyte–Platelet Adhesion in Patients Undergoing Cardiac Surgery
Greilich PE, Brouse CF, Rinder CS, Smith BR, Sandoval BA, Rinder HM, Eberhart RC, Jessen ME. Effects of ε-Aminocaproic Acid and Aprotinin on Leukocyte–Platelet Adhesion in Patients Undergoing Cardiac Surgery. Anesthesiology 2004, 100: 225-233. PMID: 14739793, DOI: 10.1097/00000542-200402000-00008.Peer-Reviewed Original ResearchConceptsEpsilon-aminocaproic acidCardiopulmonary bypassLeukocyte-platelet adhesionPlatelet activationPlatelet CD62PCardiac surgeryPlasmin activityAdministration of aprotininDouble-blind fashionMonocyte-platelet conjugatesActivation of leukocytesD-dimer formationConjugate formationAbility of aprotininMonocyte CD11bSaline groupCD11b expressionLeukocyte activationΕ-aminocaproic acidPatientsUseful markerClinical settingAprotininLeukocytesSurgery
2003
Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury
Rinder CS, Fontes M, Mathew JP, Rinder HM, Smith BR, Group M. Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury. The Annals Of Thoracic Surgery 2003, 75: 899-905. PMID: 12645714, DOI: 10.1016/s0003-4975(02)04490-9.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedCardiopulmonary BypassCD11b AntigenCoronary Artery BypassCreatinineHeart FailureHeart Valve Prosthesis ImplantationHemodynamicsHumansIntra-Aortic Balloon PumpingLeukocyte CountMiddle AgedNeutrophilsPostoperative ComplicationsProspective StudiesRisk FactorsSystemic Inflammatory Response SyndromeConceptsAcute renal injuryNeutrophil CD11b upregulationRenal injuryCardiopulmonary bypassInflammatory responseCD11b upregulationAdult respiratory distress syndromeMarkers of leukocytesPlatelet CD62P expressionPostoperative hemodynamic supportPostoperative renal injuryNeutrophil inflammatory responseSystemic inflammatory responseRespiratory distress syndromeSubset of patientsC-reactive proteinTotal neutrophil countMonocyte CD11bRenal riskHemodynamic instabilityInflammatory markersPost-CPBHemodynamic supportMyeloperoxidase levelsNeutrophil count
2002
Platelet PlA2 Polymorphism and Platelet Activation Are Associated with Increased Troponin I Release after Cardiopulmonary Bypass
Rinder CS, Mathew JP, Rinder HM, Howe J, Fontes M, Crouch J, Pfau S, Patel P, Smith BR. Platelet PlA2 Polymorphism and Platelet Activation Are Associated with Increased Troponin I Release after Cardiopulmonary Bypass. Anesthesiology 2002, 97: 1118-1122. PMID: 12411794, DOI: 10.1097/00000542-200211000-00013.Peer-Reviewed Original ResearchConceptsTroponin I concentrationsPlatelet glycoprotein IIIaCardiopulmonary bypassPlA2 polymorphismPlA2 alleleI concentrationsMyocardial injuryGlycoprotein IIIaPlatelet activationElective coronary artery bypassHigher troponin I concentrationsPostoperative troponin I concentrationsTroponin IPerioperative myocardial injuryCoronary artery bypassProthrombotic risk factorsCardiopulmonary bypass surgerySevere myocardial injuryArtery bypassBypass surgeryPlatelet polymorphismsRisk factorsCardiovascular settingsPlA2 genotypeBypass
2001
The Effects of Heparin, Protamine, and Heparin/Protamine Reversal on Platelet Function Under Conditions of Arterial Shear Stress
Griffin M, Rinder H, Smith B, Tracey J, Kriz N, Li C, Rinder C. The Effects of Heparin, Protamine, and Heparin/Protamine Reversal on Platelet Function Under Conditions of Arterial Shear Stress. Anesthesia & Analgesia 2001, 93: 20-27. PMID: 11429331, DOI: 10.1097/00000539-200107000-00005.Peer-Reviewed Original ResearchConceptsCollagen-induced thrombus formationPlatelet hemostasis timePartial thromboplastin timeAntiplatelet effectProthrombin timeAntithrombin effectPlatelet activationProtamine reversalPlatelet functionDirect antiplatelet effectCollagen-dependent platelet activationDirect thrombin inhibitorL-arginyl-chloromethyl ketoneClot Signature AnalyzerEffect of heparinCollagen-induced platelet activationEffect of protamineArterial shear stressBlood lossCardiopulmonary bypassPlatelet dysfunctionProtamine ratioPlatelet aggregometryAnticoagulant effectThromboplastin timePlatelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass
Mathew J, Rinder C, Howe J, Fontes M, Crouch J, Newman M, Phillips-Bute B, Smith B, Group T. Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass. The Annals Of Thoracic Surgery 2001, 71: 663-666. PMID: 11235724, DOI: 10.1016/s0003-4975(00)02335-3.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationPlA1/A1PlA1/A2Cardiopulmonary bypassNeurocognitive declinePlA2 polymorphismPlatelet GPIIIaState ExaminationBaseline Mini-Mental State ExaminationGreater neurocognitive declineProthrombotic genetic factorsPostoperative day 4Prothrombotic risk factorsEmbolic insultFrequent complicationPlA2 allelePlaque embolizationLocal thrombosisRisk factorsThrombotic processCardiovascular settingsPlA2 genotypeNeurocognitive changesDay 4Multivariate analysis
1999
Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBlood Loss, SurgicalCardiopulmonary BypassCognition DisordersComplement ActivationComplement C5Complement Membrane Attack ComplexCoronary Artery BypassCoronary DiseaseCreatine KinaseHumansInflammationIsoenzymesMiddle AgedMyocardial Reperfusion InjuryPostoperative ComplicationsProspective StudiesPsychological TestsSingle-Chain AntibodiesConceptsMini-Mental State ExaminationPathological complement activationCardiopulmonary bypassBlood lossMyocardial injuryC5 inhibitionTissue injuryCoronary artery bypass graft surgeryComplement inhibitorsArtery bypass graft surgeryComplement activationCognitive deficitsSingle-chain antibodyC5 complement inhibitorNew cognitive deficitsSignificant dose-dependent inhibitionBypass graft surgeryPostoperative blood lossPostoperative myocardial injurySystemic inflammatory responseComplement-mediated inflammationLeukocyte CD11b expressionNovel therapeutic strategiesComplement hemolytic activityDose-dependent fashionSelective blockade of membrane attack complex formation during simulated extracorporeal circulation inhibits platelet but not leukocyte activation
Rinder CS, Rinder HM, Smith MJ, Tracey JB, Fitch J, Li L, Rollins SA, Smith BR. Selective blockade of membrane attack complex formation during simulated extracorporeal circulation inhibits platelet but not leukocyte activation. Journal Of Thoracic And Cardiovascular Surgery 1999, 118: 460-466. PMID: 10469960, DOI: 10.1016/s0022-5223(99)70183-2.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalBlood PlateletsComplement ActivationComplement C3aComplement C8Complement Membrane Attack ComplexEnzyme-Linked Immunosorbent AssayExtracorporeal CirculationFlow CytometryHumansLeukocyte CountLeukocyte ElastaseMacrophage-1 AntigenNeutrophil ActivationNeutrophilsPlatelet ActivationPlatelet CountP-SelectinReference ValuesConceptsNeutrophil activationExtracorporeal circuitExtracorporeal circulationLeukocyte activationMembrane attack complexPlatelet activationC5b-9C5b-9 generationAttack complexC5b-9 formationMembrane attack complex formationPlatelet CD62PControl circulationCardiopulmonary bypassLate complement componentsPlatelet countMonocyte countInhibits plateletSelective blockadeLoss of monocytesExtracorporeal modelSC5b-9Complement activationComplement componentsCellular activation
1998
C3- AND C5- CONVERTASE INHIBITION PREVENTS MONOCYTE AND PMN ACTIVATION DURING IN VITRO CARDIOPULMONARY BYPASS
Lee D, Smith M, Tracey J, Johnson K, Higgins P, Yeh C, Smith B, Rinder C. C3- AND C5- CONVERTASE INHIBITION PREVENTS MONOCYTE AND PMN ACTIVATION DURING IN VITRO CARDIOPULMONARY BYPASS. Anesthesia & Analgesia 1998, 86: 1sca.. DOI: 10.1213/00000539-199804001-00001.Peer-Reviewed Original ResearchCardiopulmonary bypassPMN activation
1997
Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender
Rinder C, Mathew J, Rinder H, Tracey J, Davis E, Smith B. Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender. Translational Research 1997, 129: 592-602. PMID: 9178725, DOI: 10.1016/s0022-2143(97)90193-1.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassOlder patientsT cellsLower lymphocyte numbersPercentage of CD8Total lymphocyte countCardiac surgery patientsPostoperative day 1Age of patientsMononuclear cell subsetsNatural killer cellsExpression of CD11bPatterns of lymphocytesYears of ageEvidence of activationHLADR expressionInfectious complicationsLymphocyte subsetsElderly patientsLymphocyte countSurgery patientsYounger patientsCardiac surgeryLymphocyte numbersKiller cells
1995
Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation.
Rinder CS, Rinder HM, Smith BR, Fitch JC, Smith MJ, Tracey JB, Matis LA, Squinto SP, Rollins SA. Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation. Journal Of Clinical Investigation 1995, 96: 1564-1572. PMID: 7657827, PMCID: PMC185782, DOI: 10.1172/jci118195.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassExtracorporeal circulationSerum complement hemolytic activityComplement activationComplement componentsP-selectin-positive plateletsC5 complement componentNeutrophil CD11b upregulationSystemic inflammatory responseBlockade of C5aComplement hemolytic activityC5b-9 generationNeutrophil activationCD11b upregulationControl MAbInflammatory responseTherapeutic interventionsPlatelet activationCellular activationC5b-9BypassC5aC3a generationConjugate formationPlateletsAcadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass
Mathew J, Rinder C, Tracey J, Auszura L, O'Connor T, Davis E, Smith B. Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass. Journal Of Thoracic And Cardiovascular Surgery 1995, 109: 448-456. PMID: 7877305, DOI: 10.1016/s0022-5223(95)70275-x.Peer-Reviewed Original ResearchConceptsGranulocyte CD11bCardiopulmonary bypassReperfusion injuryIschemic tissueHigh-dose treatment groupVivo reperfusion injuryGranulocyte CD11b expressionCD11b/CD18Acadesine groupMulticenter trialCD11b expressionAdenosine levelsTreatment groupsAnimal modelsCD11bControl diluentAcadesineBypassInjuryWhole bloodGranulocyte adhesionSimilar inhibitionVivo trialsPatientsTrials
1994
Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass
Rinder C, Gaal D, Student L, Smith B. Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass. Journal Of Thoracic And Cardiovascular Surgery 1994, 107: 280-288. PMID: 8283897, DOI: 10.1016/s0022-5223(94)70482-1.Peer-Reviewed Original ResearchConceptsCongenital heart diseasePlatelet-leukocyte conjugatesNoncyanotic congenital heart diseaseCardiopulmonary bypassHeart diseasePediatric patientsNoncyanotic patientsLeukocyte activationPlatelet glycoprotein IbNeutrophil-platelet conjugatesPlatelet–leukocyte activationTermination of bypassCyanotic heart diseaseEnd of bypassMonocyte-platelet conjugatesGlycoprotein IbNoncyanotic heart diseaseActivation of plateletsInflammatory complicationsPulmonary dysfunctionCyanotic patientsPlatelet adhesion receptorsCD11b expressionClinical riskBaseline values
1992
Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion
Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion. Blood 1992, 79: 1201-1205. PMID: 1371416, DOI: 10.1182/blood.v79.5.1201.1201.Peer-Reviewed Original ResearchConceptsLeukocyte-platelet conjugatesCardiopulmonary bypassMonocyte-platelet conjugatesEnd of CPBStart of CPBActivation of monocytesAlpha-granule releaseGMP-140 expressionGranule membrane protein-140Time courseLeukocyte-platelet adhesionCD11b expressionMonocyte activationSurface CD11bWhole bloodGMP-140Surface expressionProtein 140Increased numberCD11bBypassMonocytesPlateletsPlatelet adhesionConjugatesCardiopulmonary bypass induces leukocyte-platelet adhesion
Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992, 79: 1201-1205. DOI: 10.1182/blood.v79.5.1201.bloodjournal7951201.Peer-Reviewed Original ResearchLeukocyte-platelet conjugatesCardiopulmonary bypassMonocyte-platelet conjugatesEnd of CPBStart of CPBActivation of monocytesAlpha-granule releaseGMP-140 expressionGranule membrane protein-140Time courseLeukocyte-platelet adhesionCD11b expressionMonocyte activationSurface CD11bWhole bloodGMP-140Surface expressionProtein 140Increased numberCD11bBypassMonocytesPlateletsPlatelet adhesionConjugates
1991
Modulation of Platelet Surface Adhesion Receptors during Cardiopulmonary Bypass
Rinder C, Mathew J, Rinder H, Bonan J, Ault K, Smith B. Modulation of Platelet Surface Adhesion Receptors during Cardiopulmonary Bypass. Anesthesiology 1991, 75: 563-570. PMID: 1718190, DOI: 10.1097/00000542-199110000-00004.Peer-Reviewed Original ResearchConceptsIIb/IIIaCardiopulmonary bypassGlycoprotein IIb/IIIaPlatelet activationQualitative platelet defectsGlycoprotein IVGlycoprotein IbAlpha-granule releaseGranule membrane protein-140Surface glycoprotein IbHLA APlatelet functionBaseline valuesVon Willebrand factor receptorBypassThrombospondin receptorGlycoprotein Ib expressionFlow cytometryIb expressionPlatelet defectsSelective decreasePlatelet receptorsFactor receptorReceptorsProtein 140