Xuefei Tian, MD
Research ScientistCards
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Research
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2025
GIT ArfGAP2: A Cytoskeletal Safeguard in Podocytes: Suppressing Rac1 to Combat Glomerular Injury.
Ishibe S, Tian X. GIT ArfGAP2: A Cytoskeletal Safeguard in Podocytes: Suppressing Rac1 to Combat Glomerular Injury. J Am Soc Nephrol 2025 PMID: 40257840, DOI: 10.1681/ASN.0000000707.Commentaries, Editorials and LettersEditorial: Case reports in nephrology.
Tian X, Ardiles L, Block CA. Editorial: Case reports in nephrology. Front Nephrol 2025, 5: 1595978. PMID: 40260144, DOI: 10.3389/fneph.2025.1595978.Commentaries, Editorials and LettersCRB2 Depletion Induces YAP Signaling and Disrupts Mechanosensing in Podocytes.
Sun Y, Kronenberg NM, Sethi S, Dash SN, Kovalik ME, Sempowski B, Strickland S, Raina R, Sperati CJ, Tian X, Ishibe S, Hall G, Gather MC. CRB2 Depletion Induces YAP Signaling and Disrupts Mechanosensing in Podocytes. Am J Physiol Renal Physiol 2025 PMID: 40062402, DOI: 10.1152/ajprenal.00318.2024.Peer-Reviewed Original Research
2024
Efficacy and Safety of Belimumab in Severe Lupus Nephritis: A Retrospective Single-Center Study
Aierken A, Zhuang J, Yang S, Yalikun D, Xu C, Zhang C, Tian X, Jiang H. Efficacy and Safety of Belimumab in Severe Lupus Nephritis: A Retrospective Single-Center Study. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.202486qykah2. DOI: 10.1681/asn.202486qykah2.Peer-Reviewed Original ResearchAtypical Hemolytic Uremic Syndrome with Peripheral Gangrene
Aierken A, Muhetaer G, Yang S, Zhuang J, Jiang H, Tian X. Atypical Hemolytic Uremic Syndrome with Peripheral Gangrene. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.20244hj831a8. DOI: 10.1681/asn.20244hj831a8.Peer-Reviewed Original ResearchPodocytic Infolding Glomerulopathy: A Systematic Report of 44 Cases
Shen Z, Zhang C, Zhuang J, Qu Y, Tian X, Jiang H. Podocytic Infolding Glomerulopathy: A Systematic Report of 44 Cases. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024y382k1hb. DOI: 10.1681/asn.2024y382k1hb.Peer-Reviewed Original ResearchWIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury
Wang Y, Cui C, Zhao W, Tian X, Liu P, Wei L, Zhu Z, Liu M, Fu R, Jia L. WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury. Immunobiology 2024, 229: 152832. PMID: 38943814, DOI: 10.1016/j.imbio.2024.152832.Peer-Reviewed Original ResearchAcute kidney injuryAcute tubular injuryLPS-induced acute kidney injuryHuman kidney 2Wip1 activityKidney injuryRenal tubulesUnilateral ischemia-reperfusion injurySepsis-associated acute kidney injuryRenal tubules of patientsHK2 cellsProtein levelsInduce acute injuryProximal renal tubulesWild-type p53-induced phosphatase 1Ischemia-reperfusion injuryPhosphorylation of p38 MAPKGSDMD-NHuman kidney-2 cellsSingle-cell sequencingPPM1D mRNAPhospho-p38 MAPKTubular injuryWip1 inhibitorScRNA-seqFallopian tube wrapping as a cause of catheter malfunction in peritoneal dialysis: a report of two cases and management strategies.
Chen X, Chen Z, Du Y, Tian X, Fu R. Fallopian tube wrapping as a cause of catheter malfunction in peritoneal dialysis: a report of two cases and management strategies. AME Case Rep 2024, 8: 66. PMID: 39091550, DOI: 10.21037/acr-23-201.Peer-Reviewed Case Reports and Technical NotesClinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study
Ha X, Zhao Z, Zhao T, Muhetaer G, Wang X, Bao A, Duan Y, Zhuang J, Song X, Zhou Y, Zhang Q, Wu J, Fan M, Zhang L, Tian X, Jiang H. Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study. Integrative Medicine In Nephrology And Andrology 2024, 11: e23-00018. DOI: 10.1097/imna-d-23-00018.Peer-Reviewed Original ResearchSARS-CoV-2 Omicron infectionMaintenance hemodialysisClinical characteristicsMHD patientsSARS-CoV-2 Omicron variantSARS-CoV-2Disease severityFollow-upSerum C-reactive protein levelsOmicron infectionRisk factorsC-reactive protein levelsFollow-up assessmentIndependent risk factorSpectrum of disease severityChinese adult patientsTailored treatment strategiesNegative nucleic acidAdult MHD patientsMaintenance hemodialysis patientsHigh-risk populationArterial oxygen partial pressureOmicron variantProcalcitonin levelsPrognostic factorsZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging
Jiang Q, Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani M, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X, Mani A, Gonzalez A, Goodwin J, Sessa W, Ishibe S, Jane-Wit D. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Kidney International 2024, 106: 419-432. PMID: 38797325, PMCID: PMC11343665, DOI: 10.1016/j.kint.2024.05.007.Peer-Reviewed Original ResearchVascular barrier functionEndothelial cellsReduced endothelial nitric oxideRegulator of vascular barrier functionEndothelial nitric oxide signalingENOS activityEndosome-associated proteinsBarrier functionKidney organ culturesEndothelial nitric oxideAkt-dependent mannerNitric oxide donorGTPase Rab5Nitric oxide signalingZFYVE21Live cell imagingKidney insufficiencyReporter miceTrafficking mechanismsAccelerated aging phenotypeKnockout miceInterstitial edemaKidney functionVesicular populationOxide donor
Academic Achievements & Community Involvement
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- January 11, 2023
Discoveries & Impact (January 2023)
- November 02, 2022
ASN Kidney Week 2022: Presentations from Yale Nephrology
- February 16, 2022
Discoveries & Impact (February 2022)
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