2021
Wound formation, wound size, and progression of wound healing after intratumoral treatment of mast cell tumors in dogs with tigilanol tiglate
Reddell P, De Ridder TR, Morton JM, Jones PD, Campbell JE, Brown G, Johannes CM, Schmidt PF, Gordon V. Wound formation, wound size, and progression of wound healing after intratumoral treatment of mast cell tumors in dogs with tigilanol tiglate. Journal Of Veterinary Internal Medicine 2021, 35: 430-441. PMID: 33438258, PMCID: PMC7848365, DOI: 10.1111/jvim.16009.Peer-Reviewed Original ResearchConceptsMast cell tumorsPretreatment tumor volumeIntratumoral treatmentCell tumorsTigilanol tiglateTumor volumeWound areaWound management interventionsComplete tumor resolutionWound healingConsistent clinical patternTT treatmentTumor resolutionClinical patternClinical recordsSecondary intentionComplete resolutionClinical studiesMost dogsNecrotic tumorNovel small moleculesGranulation tissueWound sizeMost woundsTumors
2020
Randomized controlled clinical study evaluating the efficacy and safety of intratumoral treatment of canine mast cell tumors with tigilanol tiglate (EBC‐46)
De Ridder TR, Campbell JE, Burke‐Schwarz C, Clegg D, Elliot EL, Geller S, Kozak W, Pittenger ST, Pruitt JB, Riehl J, White J, Wiest ML, Johannes CM, Morton J, Jones PD, Schmidt PF, Gordon V, Reddell P. Randomized controlled clinical study evaluating the efficacy and safety of intratumoral treatment of canine mast cell tumors with tigilanol tiglate (EBC‐46). Journal Of Veterinary Internal Medicine 2020, 35: 415-429. PMID: 32542733, PMCID: PMC7848366, DOI: 10.1111/jvim.15806.Peer-Reviewed Original ResearchConceptsMast cell tumorsComplete responseControl dogsAdverse eventsIntratumoral treatmentTigilanol tiglateCell tumorsClinical studiesTumor volumeModified Response Evaluation CriteriaTT treatmentOverall complete responseResponse Evaluation CriteriaCanine mast cell tumorsPhase 1Quality of lifeConcomitant medicationsTumor resolutionLocal treatmentTreatment responseSolid tumorsDogsTumorsTreatmentEfficacy
2015
Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: EXECUTIVE SUMMARY
Bays HE, Jones PH, Jacobson TA, Cohen DE, Orringer CE, Kothari S, Azagury DE, Morton J, Nguyen NT, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: EXECUTIVE SUMMARY. Journal Of Clinical Lipidology 2015, 10: 15-32. PMID: 26892119, DOI: 10.1016/j.jacl.2015.12.003.Peer-Reviewed Original ResearchConceptsNational Lipid AssociationObesity Medicine AssociationBariatric proceduresLipid levelsBariatric surgeryScientific statementCholesterol metabolismCardiovascular disease risk factorsDisease risk factorsBile acid metabolismAmerican SocietyLipid benefitsGut hormonesImmune factorsRisk factorsCardiovascular diseaseLipid associationIntestinal microbiotaEndocrine factorsBile acidsExecutive summaryLipid effectsTrace element deficienciesAcid metabolismObesityLipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: FULL REPORT
Bays HE, Jones PH, Jacobson TA, Cohen DE, Orringer CE, Kothari S, Azagury DE, Morton J, Nguyen NT, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: FULL REPORT. Journal Of Clinical Lipidology 2015, 10: 33-57. PMID: 26892120, DOI: 10.1016/j.jacl.2015.12.002.Peer-Reviewed Original ResearchConceptsNational Lipid AssociationObesity Medicine AssociationBariatric proceduresLipid levelsBariatric surgeryScientific statementCholesterol metabolismCardiovascular disease risk factorsDisease risk factorsBile acid metabolismAmerican SocietyLipid benefitsGut hormonesImmune factorsRisk factorsLipid associationIntestinal microbiotaEndocrine factorsBile acidsLipid effectsTrace element deficienciesFull reportAcid metabolismObesitySurgery
2014
T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans
McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E. T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34: 2637-2643. PMID: 25341798, PMCID: PMC4445971, DOI: 10.1161/atvbaha.114.304636.Peer-Reviewed Original ResearchConceptsCD8 T cellsSubcutaneous adipose tissueT cell profileInsulin resistanceT cellsAdipose tissueSystemic inflammationPeripheral bloodPlasma high-sensitivity C-reactive protein concentrationsHigh-sensitivity C-reactive protein concentrationsAnti-inflammatory T cellsAnti-inflammatory interleukin-10C-reactive protein concentrationsDiet-induced obese miceObesity-associated metabolic diseasesInsulin-mediated glucose disposalProinflammatory T helperPlasma interleukin-6T cell subsetsInsulin suppression testT-cell phenotypeSystemic insulin resistanceAdipose tissue biopsiesObese human subjectsReal-time polymerase chain reaction
2008
Profiling surgical staplers: effect of staple height, buttress, and overlap on staple line failure
Mery CM, Shafi BM, Binyamin G, Morton JM, Gertner M. Profiling surgical staplers: effect of staple height, buttress, and overlap on staple line failure. Surgery For Obesity And Related Diseases 2008, 4: 416-422. PMID: 18226977, DOI: 10.1016/j.soard.2007.11.008.Peer-Reviewed Original Research
2004
Bovine pericardium buttress limits recanalization of the uncut roux-en-Y in a porcine model
Morton J, Lucktong T, Trasti S, Farrell T. Bovine pericardium buttress limits recanalization of the uncut roux-en-Y in a porcine model. Journal Of Gastrointestinal Surgery 2004, 8: 127-131. PMID: 14746845, DOI: 10.1016/j.gassur.2003.09.024.Peer-Reviewed Original Research