2024
IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation.
Mullan C, Summer L, Lopez-Giraldez F, Tobiasova Z, Manes T, Yasothan S, Song G, Jane-Wit D, Saltzman W, Pober J. IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation. The Journal Of Immunology 2024, 213: 1338-1348. PMID: 39302113, PMCID: PMC11493510, DOI: 10.4049/jimmunol.2400331.Peer-Reviewed Original ResearchIL-15Surface expressionIL-1BIL-15 transcriptsEndothelial cellsCD8 T cell activationExpression of IL-15EC surface expressionIL-15 transpresentationComplement activationGraft endothelial cellsActivity of CTLT cell activationIL-15 mRNAEndothelial surface expressionAbsence of complement activationCultured human endothelial cellsIL-1-mediated activationIL-15RAProtein translationAllograft rejectionRNA polymerase II-mediated transcriptionHuman endothelial cellsSuppression of protein translationTHE U.S. NATIONAL LANDSCAPE OF TEMPORARY MECHANICAL CIRCULATORY SUPPORT
Morrison A, Mullan C, Chouairi F, Waldron C, Carnicelli A, Houston B, Ahmad T, Miller P. THE U.S. NATIONAL LANDSCAPE OF TEMPORARY MECHANICAL CIRCULATORY SUPPORT. Journal Of The American College Of Cardiology 2024, 83: 2537. DOI: 10.1016/s0735-1097(24)04527-3.Peer-Reviewed Original Research
2023
Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection
Korutla L, Hoffman J, Rostami S, Hu R, Korutla V, Markmann C, Mullan C, Sotolongo A, Habertheuer A, Romano C, Acker M, Sen S, Agarwal D, Jayaraman A, Li B, Davis M, Naji A, Vallabhajosyula P. Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection. American Journal Of Transplantation 2023, 24: 419-435. PMID: 38295008, DOI: 10.1016/j.ajt.2023.10.021.Peer-Reviewed Original ResearchAcute cellular rejectionAllogeneic transplant recipientsTransplant recipientsCellular rejectionHeart transplantationAlloreactive T cell activationEarly acute cellular rejectionT-cell receptor sequencingSyngeneic transplant recipientsCell receptor sequencingClinical heart transplantationT cell clonesNovel candidate biomarkersT cell activationQuantitative RT-PCRRecipient circulationOrgan transplantationT cellsVesicle profilesNoninvasive biomarkersCandidate biomarkersCell activationRegulatory markersDonor cardiomyocytesTransplantation
2022
Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation
Chouairi F, Mullan C, Ahmed A, Bhinder J, Guha A, Miller P, Jastreboff A, Fuery M, Chiravuri M, Geirsson A, Desai N, Maulion C, Sen S, Ahmad T, Anwer M. Clinical implications of Type 2 diabetes on outcomes after cardiac transplantation. PLOS ONE 2022, 17: e0273111. PMID: 36516178, PMCID: PMC9750001, DOI: 10.1371/journal.pone.0273111.Peer-Reviewed Original ResearchConceptsPost-transplant mortalityType 2 diabetesAllocation system changeOld allocation systemsHeart transplant recipientsOutcomes of patientsOrgan Sharing databaseProportion of patientsHeart transplantation outcomesLower likelihoodLikelihood of transplantationHigher likelihoodNew allocation systemCardiac transplantationHeart transplantationTransplant recipientsT2D patientsHeart failureSharing databaseCox regressionTransplantation outcomesUnited NetworkWorse outcomesT2DPatientsRedo mitral valve surgery: A totally endoscopic, robotic-assisted approach for adhesiolysis and complex repair.
Amabile A, LaLonde M, Hameed I, Mullan C, Degife E, Morrison A, Shang M, Komlo C, Krane M, Geirsson A. Redo mitral valve surgery: A totally endoscopic, robotic-assisted approach for adhesiolysis and complex repair. Multimedia Manual Of Cardio-Thoracic Surgery 2022, 2022 PMID: 36367136, DOI: 10.1510/mmcts.2022.061.Peer-Reviewed Case Reports and Technical NotesTotally endoscopic, robotic-assisted tricuspid valve repair with neochords.
Amabile A, LaLonde MR, Mullan CW, Hameed I, Degife E, Krane M, Geirsson A, Agrawal A. Totally endoscopic, robotic-assisted tricuspid valve repair with neochords. Multimedia Manual Of Cardio-Thoracic Surgery 2022, 2022 PMID: 36314718, DOI: 10.1510/mmcts.2022.056.Peer-Reviewed Case Reports and Technical NotesDouble Papillary Muscle Relocation: A Totally Endoscopic, Robotic-Assisted Approach.
Amabile A, LaLonde MR, Komlo CMK, Mullan CW, Shang M, Agrawal A, Geirsson A, Krane M. Double Papillary Muscle Relocation: A Totally Endoscopic, Robotic-Assisted Approach. Multimedia Manual Of Cardio-Thoracic Surgery 2022, 2022 PMID: 36314585, DOI: 10.1510/mmcts.2022.058.Peer-Reviewed Case Reports and Technical NotesSurvival After Heart Transplantation From SARS-CoV-2–Positive Donors
Mullan CW, Komlo C, Clark KAA, Sen S, Anwer M, Geirsson A, Ahmad T, Davis RP. Survival After Heart Transplantation From SARS-CoV-2–Positive Donors. JACC Heart Failure 2022, 10: 874-876. PMID: 36328657, PMCID: PMC9555312, DOI: 10.1016/j.jchf.2022.08.006.Peer-Reviewed Original ResearchMembrane attack complexes, endothelial cell activation, and direct allorecognition
Song G, Wang S, Barkestani MN, Mullan C, Fan M, Jiang B, Jiang Q, Li X, Jane-wit D. Membrane attack complexes, endothelial cell activation, and direct allorecognition. Frontiers In Immunology 2022, 13: 1020889. PMID: 36211400, PMCID: PMC9539657, DOI: 10.3389/fimmu.2022.1020889.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionIschemia-reperfusion injuryDonor-derived endothelial cellsAlloreactive T cellsT cellsDirect allorecognitionInflammatory mediatorsMembrane attack complexEndothelial cellsTissue allograftsCell activationEC activationComplement cascadeAlloimmune T cell responsesT cell-mediated inflammationSolid organ transplant rejectionCell-mediated inflammationRecipient T cellsSolid organ transplantationT cell infiltrationT cell responsesDonor endothelial cellsImmune cell activationEndothelial cell activationOrgan transplant rejectionInstitution representation in publications reporting mitral valve repair durability: A scoping review
Komlo CM, Brooks C, Amabile A, Mori M, Najem M, Mullan C, Weininger G, Krane M, Vallabhajosyula P, Geirsson A. Institution representation in publications reporting mitral valve repair durability: A scoping review. Journal Of Cardiac Surgery 2022, 37: 2163-2165. PMID: 35506749, DOI: 10.1111/jocs.16498.Peer-Reviewed Original Research
2021
Mitochondrial fission in allograft endothelial cells: A novel actionable target
Mullan CW, Pober JS. Mitochondrial fission in allograft endothelial cells: A novel actionable target. American Journal Of Transplantation 2021, 22: 337-338. PMID: 34865296, DOI: 10.1111/ajt.16911.Commentaries, Editorials and LettersImpact of Obesity on Heart Transplantation Outcomes
Chouairi F, Milner A, Sen S, Guha A, Stewart J, Jastreboff AM, Mori M, Clark KA, Miller PE, Fuery MA, Rogers JG, Notarianni A, Jacoby D, Maulion C, Anwer M, Geirsson A, Desai NR, Ahmad T, Mullan CW. Impact of Obesity on Heart Transplantation Outcomes. Journal Of The American Heart Association 2021, 10: e021346. PMID: 34854316, PMCID: PMC9075353, DOI: 10.1161/jaha.121.021346.Peer-Reviewed Original ResearchConceptsBody mass indexHigher BMI categoriesImpact of obesityHeart transplantation outcomesBMI categoriesTransplantation outcomesHeart transplantationHigher body mass indexAllocation system changeAdvanced heart failureOrgan Sharing databaseObese BMI categoriesVentricular assist deviceNew Organ ProcurementPosttransplant deathPosttransplantation deathPosttransplant mortalityBackground PatientsBMI 18.5Adult patientsCohort studyHeart failureHeart transplantSharing databaseWaitlist deathsTrends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
Fuery MA, Chouairi F, Natov P, Bhinder J, Rose Chiravuri M, Wilson L, Clark KA, Reinhardt SW, Mullan C, Miller PE, Davis RP, Rogers JG, Patel CB, Sen S, Geirsson A, Anwer M, Desai N, Ahmad T. Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates. Journal Of The American Heart Association 2021, 10: e023662. PMID: 34743559, PMCID: PMC9075266, DOI: 10.1161/jaha.121.023662.Peer-Reviewed Original ResearchConceptsLow-urgency patientsHigh-urgency patientsUrgency patientsCardiac transplantationAllocation system changeLonger waitlist timesOrgan Sharing databaseTime of transplantationCardiac transplantation candidatesNew allocation systemBaseline recipientPosttransplantation outcomesPosttransplantation survivalAdditional comorbiditiesClinical characteristicsConclusions PatientsHepatitis CIschemic timeTransplantation candidatesSharing databaseWaitlist timeWaitlist survivalUnited NetworkRetrospective analysisPatientsThe impact of trainees' working hour regulations on outcome in CABG and valve surgery in the State of New York
Amabile A, Mori M, Brooks C, Weininger G, Shang M, Fereydooni S, Komlo CM, Mullan CW, Hameed I, Geirsson A. The impact of trainees' working hour regulations on outcome in CABG and valve surgery in the State of New York. Journal Of Cardiac Surgery 2021, 36: 4582-4590. PMID: 34617327, DOI: 10.1111/jocs.16058.Peer-Reviewed Original ResearchConceptsShort-term outcomesRisk-adjusted mortality ratesDuty hour regulationsTeaching hospitalBetter short-term outcomesWorse short-term outcomesCoronary artery bypassDuty hour policiesOverall surgical volumeArtery bypassCABG surgeryValve surgeryCABG proceduresCardiac surgeryValve proceduresSurgical volumeFirst-year residentsHospital typeMortality rateSurgeryCABGCall dutiesReporting System dataGraduate Medical EducationOutcomesBrief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018
Chouairi F, Mullan CW, Ravindra N, Clark KAA, Jaffe EM, Bhinder J, Fuery M, Guha A, Ahmad T, Desai NR. Brief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018. PLOS ONE 2021, 16: e0255514. PMID: 34591847, PMCID: PMC8483306, DOI: 10.1371/journal.pone.0255514.Peer-Reviewed Original ResearchTrends in transcatheter and surgical aortic valve replacement in the United States, 2008-2018
Clark KA, Chouairi F, Kay B, Reinhardt SW, Miller PE, Fuery M, Mullan CW, Guha A, Ahmad T, Desai NR. Trends in transcatheter and surgical aortic valve replacement in the United States, 2008-2018. American Heart Journal 2021, 243: 87-91. PMID: 34571040, DOI: 10.1016/j.ahj.2021.03.017.Peer-Reviewed Original ResearchCommentary: Short-term pain, long-term gain with left ventricular function after mitral valve repair
Mullan CW, Geirsson A. Commentary: Short-term pain, long-term gain with left ventricular function after mitral valve repair. Journal Of Thoracic And Cardiovascular Surgery 2021, 166: 86-87. PMID: 34600764, DOI: 10.1016/j.jtcvs.2021.09.021.Commentaries, Editorials and LettersEvaluation of Racial and Ethnic Disparities in Cardiac Transplantation
Chouairi F, Fuery M, Clark KA, Mullan CW, Stewart J, Caraballo C, Clarke J, Sen S, Guha A, Ibrahim NE, Cole RT, Holaday L, Anwer M, Geirsson A, Rogers JG, Velazquez EJ, Desai NR, Ahmad T, Miller PE. Evaluation of Racial and Ethnic Disparities in Cardiac Transplantation. Journal Of The American Heart Association 2021, 10: e021067. PMID: 34431324, PMCID: PMC8649228, DOI: 10.1161/jaha.120.021067.Peer-Reviewed Original ResearchConceptsWhite patientsHispanic patientsBlack patientsCardiac transplantationHeart transplantationHigh riskEthnic disparitiesAdult heart recipientsAllocation system changePost-transplant deathPost-transplant mortalityOrgan Sharing databasePost-transplantation deathNew allocation systemHeart recipientsDiabetes mellitusRenal diseaseSharing databaseTransplantation ratesUnited NetworkContemporary outcomesPatientsTransplantationDonor characteristicsStudy periodMechanical ventilation at the time of heart transplantation and associations with clinical outcomes
Miller PE, Mullan CW, Chouairi F, Sen S, Clark KA, Reinhardt S, Fuery M, Anwer M, Geirsson A, Formica R, Rogers JG, Desai NR, Ahmad T. Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes. European Heart Journal Acute Cardiovascular Care 2021, 10: 843-851. PMID: 34389855, PMCID: PMC8557439, DOI: 10.1093/ehjacc/zuab063.Peer-Reviewed Original ResearchConceptsHeart transplantationMechanical ventilationSingle-organ heart transplantationMedian waitlist timeOrgan Sharing databaseTime of transplantationMultivariable logistic regressionMultivariable adjustmentWaitlist timeClinical outcomesSharing databasePoor outcomeVentilated patientsUnited NetworkTemporary mechanical supportClinical acuityTransplantationPatientsPrevious dialysisLogistic regressionMortalityStrong associationReasonable outcomesOutcomesAssociationCommentary: Radical root resection for prosthetic valve endocarditis
Mullan CW, Geirsson A, Assi R. Commentary: Radical root resection for prosthetic valve endocarditis. JTCVS Techniques 2021, 9: 28-29. PMID: 34647048, PMCID: PMC8501240, DOI: 10.1016/j.xjtc.2021.07.012.Commentaries, Editorials and Letters